Nitrous Oxide - MCI
Nitrous Oxide - MCI
Nitrous Oxide - MCI
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Problems with <strong>Nitrous</strong> <strong>Oxide</strong><br />
Occupational Exposure<br />
• Occupational exposure limits (OELs, 8h time‐weighted average) variable 25‐<br />
100 ppm<br />
– Pre‐scavenging often exceeded<br />
• May have effect via inhibition methionine synthetase<br />
• No conclusive evidence for<br />
– Reproductive, genetic, haematologic or genetic effect<br />
– Many problems in occupational studies<br />
• Inconclusive results & many design problems<br />
• Very high doses vs not scavenged vs scavenged<br />
• Confounding agents, anaesthetics Sanders Anesthesiology 2008
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