In Pharmaceutical Sciences (Pharmacognosy)

Niruroidine
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INTRODUCTION
Name of Compound Structure Species & ref.
3. Lignans:
H
N
H
O
O
H
H H
OH
niruroides (50)
The literature survey of the genus Phyllanthus reveals the
presence of large number of lignans that are summarized in the
following table:
Table (5): Lignans present in genus Phyllanthus:
Name of Compound Structure
A- Diarylbutane type:
Species & ref.
R1= R2= OMe, R3= H;
Phyllanthin
R1 CH2OMe urinaria (23)
R1= R2= OH, R3= OMe;
Demethylenedioxyniranthin
R= H;
5-demethoxyniranthin
R= OMe;
Niranthin
R1= H, R2= ═O;
Hinokinin
R1= ═O, R2= H;
Heliobuphthalmin lactone
(+)-8-(3,4-(methylenedioxy) benzyl)-8'-
(3',4'-dimethoxy-benzyl) butyrolactone
R 2
O
O
O
O
O
O
R 3
R
OMe
CH2OMe
OMe
CH 2 OMe
OMe
OMe
O
OMe
CH 2OMe
O
R 1
O
R 2
O
O
OMe
debilis (31)
(32, 51- 59)
niruri
amarus (60)
niruri
urinaria
virgatus (63)
(32, 51, 52, 56)
urinaria
niruri (56)
virgatus (63)
virgatus (63)
(23, 61, 62)
(23, 61, 62)