In Pharmaceutical Sciences (Pharmacognosy)

More documents

Recommendations

Info

PART Π Phytochemical Investigation Of Phyllanthus atropurpureus Boj. Hort. Maurit. Chapter 1: Preliminary phytochemical investigation of Phyllanthus atropurpureus Boj. Hort. Maurit……………………………. Chapter 2: Successive extraction of the powdered Phyllanthus atropurpureus Boj. Hort. Maurit. with selective organic solvents and examination of the respective extracts………... Chapter 3: Extraction of the powdered Phyllanthus atropurpureus Boj. Hort. Maurit. and fractionation of the extract……………… Chapter 4: Investigation of light petroleum soluble fraction and analysis of the fatty acid constituents of Phyllanthus atropurpureus Boj. Hort. Maurit……………………………… Chapter 5: Isolation and characterization of three materials from light petroleum soluble fraction of Phyllanthus atropurpureus Boj. Hort. Maurit……………………………………..……… Chapter 6: Isolation and characterization of six materials from ethyl acetate soluble fraction of Phyllanthus atropurpureus Boj. Hort. Maurit…………………………………………………. PART ΠІ Biological Activities of Phyllanthus atropurpureus Boj. Hort. Maurit. І- Antihepatotoxic Activity…....………………………….……………. Π- Anticancer activity…..………………………….………………....... ІΠ - Antimicrobial Activity …..………………………….……............. Summary……………………….…………………………… References………………………….………………………… Arabic summary……………………………………………. 108 110 113 116 122 138 195 208 213 215 219
ﷲ ﺭﻜﺸﻟﺍ ﻭ ﺩﻤﺤﻟﺍ ACKNOWLEDGEMENT First of all, my deepest gratitude to ALLAH, the source of all gifts and blessings. I would like to express my deep feeling of gratitude and sincere appreciation to Prof. Dr. Taha M. Sarg, Professor of Pharmacognosy, Faculty of Pharmacy, Zagazig University, for his kind supervision, valuable scientific guidance, directions, comments and revision. I am wholeheartedly appreciating his effort to complete this work. I am very grateful with sincere appreciation to Prof. Dr. Afaf El-Sayed Abdel-Ghani, Professor of Pharmacognosy, Zagazig University for her kind direct supervision, guidance, direction, comment, continuous help, direct encouragement and persistent help during practical work as well as continuous unlimited help during this work. I am greatly indebted and grateful with the deep thanks to Dr. Rawia Abdel-Hady Zayed, Assistant Professor of Pharmacognosy, Faculty of Pharmacy, Zagazig University for her kind supervision, directions and comments. I would like to express my deep feelings of gratitude to Prof. Dr. Ahmed Fahmy, Professor of Pharmacology, and Shimaa El-Shazly, Assistant Lecturer of Pharmacology, Faculty of Pharmacy, Zagazig University for carrying out the pharmacological screening. I would like to express my deep feelings of gratitude to Prof. Dr. Fathy Serry, Professor of Microbiology, and Ahmed Olwan, Assistant Lecturer of Microbiology, Faculty of Pharmacy, Zagazig University for carrying out the antimicrobial activity. My thanks also due to Dr. Dalia Hamdan, Lecturer of Pharmacognosy, Faculty of Pharmacy, Zagazig University for her kind help in carrying out the spectral analysis of some of the isolated compounds. I wish to express my cordial thanks to the staff members and my colleagues in Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, for their positive support, help and encouragement and to all who contributed by one way or another to the realization of this work. Finally, this work is dedicated to My Parents, My Precious Husband, My Son and My Family who helped and supported me throughout all the hard and exhausting times till this work comes out to light. MAY AHMED MOHAMED AHMED
Page 1 and 2: A PHARMACOGNOSTICAL STUDY OF PHYLLA
Page 3 and 4: A PHARMACOGNOSTICAL STUDY OF PHYLLA
Page 5 and 6: ﻢﻴﺣﺮﻟﺍ ﻦﲪﺮﻟﺍ
Page 7: CONTENTS List of Figures………
Page 11 and 12: LIST OF FIGURES Figure Fig. 26: Fig
Page 13 and 14: LIST OF FIGURES Figure Fig. 70& 71
Page 15 and 16: LIST OF TABLES Table Table 27 Table
Page 17 and 18: LIST OF ABBREVIATIONS AIDS ALT ANOV
Page 19 and 20: Introduction - 1 - INTRODUCTION Fam
Page 21 and 22: - 3 - INTRODUCTION placentation. St
Page 23 and 24: - 5 - INTRODUCTION Taxonomical posi
Page 25 and 26: - 7 - INTRODUCTION 11. P. urinaria
Page 27 and 28: (F) Timber plants (1) : - 9 - INTRO
Page 29 and 30: R= Me; Friedelin R= COOH; Polpunoni
Page 31 and 32: Fraternusterol - 13 - INTRODUCTION
Page 33 and 34: 2. Alkaloids: - 15 - INTRODUCTION A
Page 35 and 36: Dextrobursehernin - 17 - INTRODUCTI
Page 37 and 38: Urinaligran Pinoresinol R1= ═O, R
Page 39 and 40: - 21 - INTRODUCTION Table (6): Hydr
Page 41 and 42: - 23 - INTRODUCTION Name of Compoun
Page 51 and 52: - 33 - INTRODUCTION The Biological
Page 53 and 54: 5. Effect on respiratory system: -
Page 55 and 56: - 37 - INTRODUCTION anti-inflammato
Page 57 and 58: AIM OF THE PRESENT WORK - 39 - INTR
Page 59 and 60:
- 41 - INTRODUCTION These solvents
Page 61 and 62:
- 43 - INTRODUCTION 11. GLC analysi
Page 63 and 64:
- 45 - PART I Phyllanthus atropurpu
Page 65 and 66:
• The calyx: - 47 - PART I The ca
Page 67 and 68:
- 49 - PART I The root (Fig. 3) is
Page 69 and 70:
Fig. (4): Sketch of Phyllanthus atr
Page 71 and 72:
Fig. (5): The flower. A. Two lobes
Page 73 and 74:
THE LEAF - 55 - PART I A transverse
Page 75 and 76:
- 57 - PART I The spongy tissue (Fi
Page 77 and 78:
- 59 - PART I Table (10): Microscop
Page 79 and 80:
A B pr.cr. - 61 - u.ep. col. pal. l
Page 81 and 82:
A E C F - 63 - pa. sec. Pr.cr. c.cr
Page 83 and 84:
- 65 - PART I The rest of the corte
Page 85 and 86:
C c.cr. A E D pr.cr. v. ep. c.col x
Page 87 and 88:
- 69 - PART I 8. Fragments of the l
Page 89 and 90:
The Epidermis: - 71 - PART I The ep
Page 91 and 92:
Fig. (9): The old stem. - 73 - PART
Page 93 and 94:
Fig. (10): The young stem. - 75 - P
Page 95 and 96:
The Vascular Tissue: - 77 - PART I
Page 97 and 98:
THE POWDERED STEM - 79 - PART I The
Page 99 and 100:
The Pericycle: - 81 - PART I The pe
Page 101 and 102:
C A D E ep. col. c. xy. p. c.cr. c.
Page 103 and 104:
- 85 - PART I The epidermal cells s
Page 105 and 106:
Fig. (12): The calyx. - 87 - PART I
Page 107 and 108:
3-THE ANDROECIUM - 89 - PART I The
Page 109 and 110:
Fig. (13): The Androecium: - 91 - P
Page 111 and 112:
1- The ovary: 4-THE GYNAECIUM - 93
Page 113 and 114:
3- The stigma: - 95 - PART I The ep
Page 115 and 116:
C G E A D o.ep. col. m c.cr . . Ph.
Page 117 and 118:
- 99 - PART I 9. Fragments of the e
Page 119 and 120:
- 101 - PART I colour with ferric c
Page 121 and 122:
Fig. (15): The old root: - 103 - PA
Page 123 and 124:
Fig. (16): The root and rhizome: -
Page 125 and 126:
THE POWDERED ROOT AND RHIZOME - 107
Page 127 and 128:
CONCLUSION - 109 - PART II From the
Page 129 and 130:
Table (13): Physical, Chromatograph
Page 131 and 132:
- 113 - PART II The air-dried powde
Page 133 and 134:
Air - Dried Powdered organs Total E
Page 135 and 136:
I. Saponification of Light Petroleu
Page 137 and 138:
Results and conclusion: - 119 - PAR
Page 139 and 140:
Retention time - 121 - PART II Fig.
Page 141 and 142:
• Isolation of materials (1, 2):
Page 143 and 144:
Discussion and conclusion 125 PART
Page 145 and 146:
Characterization of material 2 127
Page 147 and 148:
129 PART II fragments at m/z 396, 3
Page 149 and 150:
+ H HO m/z 273 m/z 303 + -R HO HO m
Page 151 and 152:
- 133 - PART II 177.79 (C-1), 130.8
Page 153 and 154:
- 135 - PART II Fig. (23): IR spect
Page 155 and 156:
m/z 254 - CO m/z 124 (1.6%) H 3C H
Page 157 and 158:
- 139 - PART II The chromatoplates
Page 159 and 160:
- 141 - PART II Description of the
Page 161 and 162:
- 143 - PART II and 0.66 (solvent s
Page 163 and 164:
• A broad singlet at δ 6.615 - 6
Page 165 and 166:
- 147 - PART II Fig. (27): IR spect
Page 167 and 168:
- 149 - PART II Fig. (30): 13 C-NMR
Page 169 and 170:
Characterization of material 5 - 15
Page 171 and 172:
- 153 - PART II bathochromic shift
Page 173 and 174:
- 155 - PART II Fig. (34): Mass spe
Page 175 and 176:
Characterization of material "6" -
Page 177 and 178:
- 159 - PART II carbonyl besides an
Page 179 and 180:
- 161 - MeOH+ NaOMe MeOH PART II Fi
Page 181 and 182:
- 163 - PART II Fig. (40): 1 H-NMR
Page 183 and 184:
- 165 - PART II Fig. (44): APT spec
Page 185 and 186:
+ HO HO HO O HO O O m/z 309 ( 56.2
Page 187 and 188:
Table (26): 1 HNMR Spectral Data of
Page 189 and 190:
- 171 - PART II Comparison Robustas
Page 191 and 192:
- 173 - PART II Fig. (51): Mass spe
Page 193 and 194:
- 175 - PART II Column Chromatograp
Page 195 and 196:
• Isolation of material "8": - 17
Page 197 and 198:
- 179 - PART II m/z (% relative abu
Page 199 and 200:
─ MeOH ----MeOH+NaOMe - 181 - ─
Page 201 and 202:
MeO m/z 313 -OH m/z 296 -OH OMe O O
Page 203 and 204:
Mass Spectral Analysis: - 185 - PAR
Page 205 and 206:
- 187 - PART II The 1 H-NMR spectru
Page 207 and 208:
─ MeOH ----MeOH+NaOMe ─ MeOH+Na
Page 209 and 210:
- 191 - PART II Fig. (60): FAB-MS s
Page 211 and 212:
- 193 - PART II Fig. (64): gHSQCAD
Page 213 and 214:
Introduction: Biological Activities
Page 215 and 216:
- 197 - PART III • Subgroup (B) (
Page 217 and 218:
- 199 - PART III to form pyruvate h
Page 219 and 220:
- 201 - PART III • The antioxidan
Page 221 and 222:
ALT value 50 40 30 20 10 0 - 203 -
Page 223 and 224:
- 205 - PART III • Potent antioxi
Page 225 and 226:
- 207 - PART III Hort. Maurit. in t
Page 227 and 228:
3. Anti-tumour activity - 209 - PAR
Page 229 and 230:
- 211 - PART III As shown in Fig. (
Page 231 and 232:
C-Antimicrobial activity - 213 - PA
Page 233 and 234:
REFERENCES - 219 - References 1. Sh
Page 235 and 236:
- 221 - References 27. Miguel, O. G
Page 237 and 238:
- 223 - References 54. Hussain, R.
Page 239 and 240:
- 225 - References 78. El-Mekawy, S
Page 241 and 242:
- 227 - References vivo hepatoprote
Page 243 and 244:
- 229 - References 127. Islam, A.;
Page 245 and 246:
- 231 - References 147. Bandyopadhy
Page 247 and 248:
- 233 - References 168. Kassuya, C.
Page 249 and 250:
- 235 - References 195. Vogel, A.I.
Page 251 and 252:
- 237 - References 225. Hernandez-M
Page 253 and 254:
- 239 - References 253. Bosisio, E.
Page 255 and 256:
- 216 - SUMMARY 5. Short petiole sh
Page 257 and 258:
- 218 - SUMMARY 9. Quercetin-7- O-g
Page 259 and 260:
. ﺔﯿﺗﺎﺒﻧا بﻮﻘﺛ
Page 261 and 262:
2009
Page 263 and 264:
ﺝﺮﺳ ﻰﻔﻄﺼﻣ ﻪـﻃ
show all

In Pharmaceutical Sciences (Pharmacognosy)

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?