morphological changes of reversible injury

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NECROSIS • Type of cell death associated with loss of membrane integrity & leakage of cellular contents resulting in dissolution due to enzymatic degradation • Usually involves large numbers of cells. • Inflammation and injury to neighboring cells. Types; • Coagulative necrosis, • Caseous necrosis • Liquefactive necrosis • Fat necrosis • Fibrinoid necrosis MORPHOLOGICAL CHANGES OF NECROSIS Nuclear Changes appear in one of the three patterns: • Karyolysis • Pyknosis • Karyohexis Karyolysis Breakdown of DNA and chromatin because of enzymatic degradation by endonucleases PYKNOSIS • Nuclear shrinkage and increased bosophilia, • chromatin condenses into solid,shrunken basophilic mass. • fragmentation of pyknotic nucleus. Karyohexis
FATES OF NECROTIC CELL • May persists for sometimes • Digested by enzymes • Replaced by myelin figures • Phagocytosed by other cells • Further degraded in to fatty acids • Calcified NECROSIS: TYPES Macroscopic • Coagulative necrosis, • Caseous necrosis • Liquefactive necrosis • Fat necrosis Microscopic • Fibrinoid necrosis COAGULATIVE NECROSIS “Underlying tissue architecture is preserved for several days” can be observed by light microscopy Is typically seen in hypoxic (low-oxygen) environments Examples Infarcts of solid organs such as Heart, spleen, kidney (except brain).
Page 1 and 2: MORPHOLOGICAL ALTERATIONS IN CELL I
Page 3: MORPHOLOGICAL CHANGES OF REVERSIBLE
Page 7 and 8: GRANULOMA • The necrotic area is

morphological changes of reversible injury

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