Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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General Facts About AEDs<br />
• Good oral absorption and bioavailability<br />
• Most metabolized in liver but some excreted<br />
unchanged in kidneys<br />
• Classic AEDs generally have more severe CNS<br />
sedation than newer drugs (except<br />
ethosuximide)<br />
• Because <strong>of</strong> overlapping mechanisms <strong>of</strong> action,<br />
best drug can be chosen based on minimizing<br />
side effects in addition to efficacy