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Pharmacology of Antiepileptic Drugs

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Regulation <strong>of</strong> Neurotransmitter release<br />

• Several AED have actions that result in the<br />

regulation <strong>of</strong> neurotransmitter release from the<br />

presynaptic terminal, such as lamotrigine, in<br />

addition to their noted action on ion channels or<br />

receptors.<br />

• Levetiracetam appears to have as its primary<br />

action the regulation <strong>of</strong> neurotransmitter release<br />

by binding to the synaptic vesicle protein SV2A:

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