Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Targets for AEDs<br />
• Increase inhibitory neurotransmitter system—<br />
GABA<br />
• Decrease excitatory neurotransmitter system—<br />
glutamate<br />
• Block voltage-gated inward positive currents—<br />
Na + or Ca ++<br />
• Increase outward positive current—K +<br />
• Many AEDs pleiotropic—act via multiple<br />
mechanisms