Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Felbamate<br />
• Antagonizes the glycine site on the NMDA<br />
receptor and blocks Na+ channels*<br />
• Very potent AED lacking sedative effect (unlike<br />
nearly all other AEDs)<br />
• Associated with rare but fatal aplastic anemia,<br />
hence is restricted for use only in extreme<br />
refractory epilepsy