Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Drug Interactions<br />
• Many AEDs are notable inducers <strong>of</strong> cytochrome<br />
P450 enzymes and a few are inhibitors.<br />
• Of the classic AEDs, phenytoin, carbamazipine,<br />
phenobarbital, and primidone are all strong<br />
inducers <strong>of</strong> cytochrome P450 enzymes. They<br />
are autoinducers, in other words they increase<br />
their own metabolism.<br />
• Valproate inhibits cytochrome P450 enzymes.
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