10 0 - EleA@UniSA - Università degli Studi di Salerno

In the C-terminal region, the TRP domain, a highly conserved region of 25
amino acids, is common amongst all TRPV, TRPC and TRPM channels
The functional role of the TRP domain in these channels is unclear. Some
evidence suggests that in TRPV1, the TRP domain serves as an association
domain for tetramerization and is therefore critical for assembly of TRPV1
subunits. In TRPM ion channels, however, it has been proposed to play a role in
activation and desensitization 35a (Figure 1.29)
FIGURE 1.29 Topology of TRP receptors family
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