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UCB SA - BNP Paribas Fortis

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marketing and supply agreement dated May 1999 which was terminated by Novartis in 2007. The term<br />

of the agreement is until 31 December 2016.<br />

On 24 August 2009 Novartis and Schwarz Pharma Deutschland GmbH entered into two further copromotion<br />

agreements, one for Novartis’ product Dafiro®, and one for Novartis’ products Jalra® and<br />

Icandra®. Both agreements run until 31 August 2019.<br />

Osmotica Pharmaceutical Corp.<br />

<strong>UCB</strong> has an exclusive license to sell the venlafaxine extended-release tablet product from Osmotica<br />

Pharmaceutical Corp. in the U.S. The term of the agreement extends until 14 July 2013.<br />

Otsuka Pharmaceutical Company Limited<br />

In November 2002, Otsuka Pharmaceuticals and Schwarz Pharma entered into a development, license<br />

and supply agreement for Neupro® (rotigotine) in Japan. Under this agreement, Otsuka<br />

Pharmaceuticals develops Neupro® (rotigotine) for the Japanese market and has been granted exclusive<br />

licence rights under Neupro® (rotigotine) patents and know-how for Japan.<br />

In June 2008, Otsuka Pharmaceuticals and <strong>UCB</strong> entered into co-promotion and co-development<br />

agreements in relation to Cimzia® in Japan and Korea, and Keppra® in Japan. The term of each of<br />

these agreements is, in relation to Cimzia®, for a period of 11 years after the date of launch of the<br />

licensed product, and in relation to Keppra® for a period of ten years after the launch of the licensed<br />

product. A co-promotion agreement between Otsuka Pharmaceuticals and <strong>UCB</strong> in relation to PletaaL®<br />

in Japan was also entered into in June 2008.<br />

Pfizer Inc.<br />

In April 2006, Pfizer Inc, Schwarz Pharma and Schwarz Pharma Limited/Ireland entered into an<br />

agreement under which Pfizer was granted a worldwide exclusive license under patents and know-how<br />

related to fesoterodine. The product Toviaz® for fesoterodine has already been launched by Pfizer in<br />

the US and Europe. The initial term of the agreement runs until the occurrence of Significant Generic<br />

Competition (as defined in the agreement), on a country-by-country and licensed product-by licensed<br />

product basis.<br />

Sanofi-Aventis US LLC<br />

In September 2006, <strong>UCB</strong> Inc. and Sanofi-Aventis US LLC. entered into an agreement to co-promote<br />

Xyzal® (levocetirizine) in the United States. The agreement extends until 31 December 2013.<br />

(b) Research and Development Agreements<br />

Amgen Inc.<br />

An exclusive collaboration and license agreement entered in May 2002 by Celltech R&D Limited, an<br />

entity which was acquired by the <strong>UCB</strong> Group in connection with its acquisition of Celltech in 2004, and<br />

Amgen Inc. to develop, market and sell antibody products targeting the sclerostin protein, including<br />

CDP7851. The agreement expires if the parties cease to develop or commercialise the licensed product.<br />

Harris FRC<br />

In December 1999, Harris FRC and Schwarz Pharma entered into a development agreement on the<br />

development by Schwarz of lacosamide; in particular in the indications of epilepsy and neuropathic<br />

A11250830/2.25/23 Oct 2009 84

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