Issue 12 - amam-ayurveda.org

More documents

Recommendations

Info

FORMULATION COMPOSITION: 1. Patha API Cissampelos pareira Rt. 1 part 2. Jambu -bija majja API Syzygium cumini Enm. 1 part 3. Amra-bija majja API Mangifera indica Enm. 1 part 4. Shilabheda (Pashanabheda API) Bergenia ligulata Rz. 1 part 5. Rasanjana API Berberis aristata Rt./St. Ext. 1 part 6. Ambashthaki API Hibiscus sabdariffa Rt. 1 part 7. Mocarasa (Shalmali) Salmalia malabarica Exd. 1 part 8. Samanga (Lajjalu) API Mimosa pudica Rt./Pl. 1 part 9. Padma kesara (Kamala) Nelumbo nucifera Adr. 1 part 10. Vahlika (Kumkuma API) Crocus sativus Stl./Stg. 1 part 11. Ativisha API Aconitum heterophyllum Rt. Tr. 1 part 12. Musta API Cyperus rotundus Rf.Tr. 1 part 13. Bilva API Aegle marmelos Rt./St.Bk. 1 part 14. Lodhra API Symplocos racemosa St.Bk. 1 part 15. Gairika (Shuddha) API Red ochre 1 part 16. Katphala API Myrica nagi (M. esculenta) St. Bk. 1 part 17. Marica API Piper nigrum Fr. 1 part 18. Shunthi API Zingiber officinale Rz. 1 part 19. Mridvika (Draksha API) Vitis vinifera Dr. Fr. 1 part 20. Rakta candana API Pterocarpus santalinus Ht. Wd. 1 part 21. Katvanga (Araluka API) Ailanthus excelsa St. Bk. 1 part 22. Vatsaka (Kutaja API) Holarrhena antidysenterica St. Bk. 1 part 23. Ananta (Shveta sariva API) Hemidesmus indicus Rt 1 part 24. Dhataki API Woodfordia fruticosa Fl. 1 part 25. Madhuka (Yasti API) Glycyrrhiza glabra Rt. 1 part 26. Arjuna API Terminalia arjuna St. Bk. 1 part Method of preparation: Take all the ingredients of pharmacopoeial quality. Treat Gairika (No. 15) to prepare Shuddha Gairika (Appendix 6.2.7.2.), powder and pass through sieve number 85. Clean, dry and powder ingredients numbered 1 to 26 individually (except 15) and pass through sieve number 85. Weigh separately each powdered ingredient and mix together in specified ratio. Pass through sieve number 44 to prepare a homogeneous blend. Pack it in tightly closed containers to protect from light and moisture. Description: Reddish brown-coloured fine powder with a pungent odour and a bitter, sweet taste. The powder completely pass on through sieve number 44 and not less than 50 per cent pass on through sieve number 85. Identification Thin Layer Chromatography: Pharmocopial Standards For Pushyanuga Churna Extract 4 g of churna in alcohol (25 ml x 3) under reflux on a waterbath for 30 min filter, concentrate to 10 ml and carry out the thin layer chromatography. Apply 10 μl of the extract on TLC plate and develop the plate to a distance of 8 cm using toluene : ethyl acetate (5 : 2) as mobile phase. After development, allow the plate, to dry in air and examine under ultraviolet light (366 nm). It shows major spots at Rf 0.18 (blue), 0.73 info Ayurveda, Volume 1, No.12, April-June’ 2012 PUSHYANUGA CHURNA (API PART II, VOL.I, PG.55-56) DEFINITION:Pushyanuga Churan is a powder preparation made with the ingredients in the Formulation composition given below (fluorescent blue). Spray the plate with vanillin-sulphuric acid reagent followed by heating at 1100 for about 10 min and observe under visible light. The plate shows major spots at Rf 0.13 (grey), 0.27 (purple), 0.33 (yellow), 0.53 (purple), 0.66 and 0.97 (both purple). Physico-chemical parameters: Loss on drying at 105 degree: Not more than 11 per cent, Total ash: Not more than 15 per cent, Acid-Insoluble ash: Not more than 4 per cent, Alcohol-soluble extractive: Not less than 12 per cent, Water-soluble extractive: Not less than 13 per cent, pH (10% )aqueous solution: 5 to 6, Other requirements: Microbial limit: As in Appendix 2.4 of the book. Aflatoxin: As in Appendix 2.7 of the book. Storage: Store in a cool place in tightly closed containers, protected from light and moisture. Therapeutic uses: Asrigdhara (Menorrhagia), Shvetapradara (Leucorrhoea), Rajodosha (Menstrual disorder), Arsha (Piles), Yonidosha (disorders of female genital tract). Dose: 6 g daily in divided dose. Anupana: Milk or Tandulodaka. 10
Observational Clinical Study On Basant Kusumarkar Ras In Diabetes & Diabetic Neuropathy INVESTIGATORS: Dr. Ashok Kumar Jain, Head, Department of Ayurveda, Panchkarma & Yoga and Dr. T. K. Das, Chief Neurologist, at SVS Marwari Hospital, Kolkata 1. INTRODUCTION: Diabetes mellitus – generally termed as Madhumeha in Ayurvedic terminology, is a frequent clinical problem. The incidence of Diabetes has been on a constant rise during last few decades more in particular, in the developing countries like India. Insulin is a hormone produced by β islets of Langerhan’s cells in pancreas and this hormone is implicated to play a vital role in the metabolism of carbohydrates and utilization of glucose. Diabetes is characterized by a defective synthesis of insulin. Based on the mode of onset and the extent of damage to the insulin producing cells, diabetes is clinically classified into two types. The first type is termed as insulin dependent Diabetes mellitus [IDDM] and other is termed as Non-Insulin Dependent Diabetes Mellitus [NIDDM]. Modern therapeutic approaches have been fairly successful to handle the primary sequel of the problem, the hyperglycaemia. In case of IDDM, direct administration of Insulin and in case of NIDDM, hypoglycaemic agents have been successfully employed. Notwithstanding these developments, there are two major areas of concern. The first one being the incidence and distribution of diabetes. Of an estimated 80 million of diabetics, over 50m. belong to heavily populated, developing countries like India. The incidence also leans primarily, towards urban population. About 1.5% of urban population is diabetics as against a 0.8% rural population. There are countries/ communities with over 35% population being diabetics. Going by the upward trends in diabetic population the incidence appears to reach a phenomenally complex stage. The second important issue is the secondary sequel to diabetes. Many internal organs are likely to be effected due to a paradoxical glucose metabolism. Of all the diabetic maladies, diabetic neuropathy affects almost 30% cases in maturity on-set diabetes. In fact, the on-set of diabetes is often manifested by early changes of neuropathy like, tingling sensations in soles and palms, muscular pain in lower extremities, claudication etc. Thus, neuropathy is essentially identified together with diabetes mellitus. Unfortunately, the sequel of diabetes is mostly irreversible and there appears no practical approach to address them. On the other hand, Ayurveda has laid down a range of therapeutic measure to address various issues linked to diabetes or madhumeha. Many studies were conducted on a number of herbs mentioned in Ayurvedic literature with an objective to develop natural hypoglycaemic agents. The success in this direction has been very little for, most of the herbs failed to reduce blood sugar levels in the desired manner. The altered approach of these investigations was found to more effective, where, an ayurvedic medicinal plant is used as an adjuvant therapy to overcome drug resistance in diabetes. However, the efficacy of Ayurvedic drugs or formulations in different complications of diabetes was sparingly reported. Basant Kusumakar Ras in Diabetes: Basant Kusumakar Ras is a generic Ayurvedic, herbo-mineral formulation info Ayurveda, Volume 1, No.12, April-June’ 2012 described in ancient Ayurvedic texts. As per Rasendrasar Sangraha, it contains Swarna Bhasma, Rajata Bhasma, Vanga Bhasma, Naga Bhasma, Kantaloha Bhasma, Abhraka Bhasma, Pravala Bhasma, and Mukta Bhasma. The blend is further processed in the extracts of 9 herbal ingredients and flavoured with Musk. Basant Kusumakar Ras is primarily, a Rasayana formulation but the text enumerates diabetes as one of its main therapeutic indication. The formulation is acclaimed to strengthen physiology as whole, to prevent loss of hair, premature graying of hair, to promote memory and fertility. Considering these descriptions, Ayurvedic physicians often recommend Basant Kusumakar Ras to improve/maintain the quality of life in diabetic patients. However, there have been no scientific reports to validate the acclaimed clinical usage of this formulation. Dabur Research centre have concluded experimental studies in collaboration with Department of Pharmacology, AIIMS – where Basant Kusumakar Ras was found to be having some improvement in blood sugar in Alloxan induced diabetic rats. This study thus succeeded to shed a little light on the role of formulation in diabetes mellitus. However, the role of Basant Kusumakar Ras in improving the quality of life during diabetic phase remains to be addressed. It is with this viewpoint; this observational clinical study was conducted at SVS Marwari Hospital, Kolkota from August 1998 to September. 2000 2. OBJECTIVES OF THE STUDY: 2.1. To ascertain the clinical efficacy of Basant Kusumakar Ras in controlling blood sugar as an adjuvant. 2.2. To evaluate the role of Basant Kusumakar Ras in diabetic neuropathy. 3. MATERIAL & METHODS: 3.1. Inclusion Criteria: • Patients of both genders, suffering from clinically established diabetes for a period not less than 5 years duration and with a basal blood sugar levels of not less than 170 mg/dl were included in the study. • Both Insulin dependent [IDDM] and non-Insulin dependent [NIDDM] types of diabetics were included in the study. • Only those patients suffering from a marked degree of polyneuritis were included. 3.2. Exclusion Criteria: • Pregnant women were excluded from the scope of this study. • Patients having renal impairment, hypertension and other forms of cardiovascular problems, liver afflictions were also excluded for the purpose of the study. 3.3. Study Design: Open label prospective study 3.4. Enrollment & Method of Study: The study was conducted at the SVS Marwari Hospital of Calcutta in 11
Page 1 and 2: President’s Message May your Bais
Page 3 and 4: Nandita Vijay, Bengaluru, Thursday,
Page 5 and 6: Pharmocopial Standards For Ayurvedi
Page 7 and 8: AMRA (Seed) (API Part -I, Vol. III,
Page 9: INDRAYAVA (Seed) (API Part I, Vol.I
Page 13 and 14: Table 4: Effect of Basant Kusumakar
Page 15 and 16: Herbal International Summit cum Exp

Issue 12 - amam-ayurveda.org

Create successful ePaper yourself

Delete template?

Save as template?