S3-Guideline “Exocrine Pancreatic Carcinoma” 20071 ... - DGVS

450
Leitlinie
The methodologic recommendations of the AWMF on the preparation
of guidelines (http://www.awmf-leitlinien.de), the
guideline manual of the Medical Center of Quality in Medicine
(http://www.aezq.de), and the German Instrument on Methodologic
Guideline Evaluation (http://www.delbi.de) were the
basis for the organization of the guideline procedure. As is demonstrated
in the following chapter (guideline report), the
guideline fulfills the criteria of an evidence and consensusbased
guideline (S3).
This guideline is estimated to be valid for 3 years. If during this
time important changes in care become evident, the coordination
groups will decide whether individual topics or the complete
guideline must be updated ahead of time.
The preparation of the guideline was financially supported by
the DGVS and the DKG. The work of the participants taking
part in the consensus process and the resulting recommendations
were not influenced by this support.
This manuscript is the English version of the German guidelines
that were published in the Zeitschrift für Gastroenetrologie
in June 2007 [1].
Organizational procedure and methodologic basis of
the consensus process (guideline report)
!
Following the commission by the DGVS and the DKG, the organizational
procedure for the guideline preparation was discussed
with the chairman of the guideline commission, Prof. H.-K.
Selbmann. Subsequent methodologic supervision was done by
the vice chairman Dr. Ina Kopp. The guideline project was registered
at the AWMF on July 4, 2005 (AWMF-Register-No. 032/
010).
Recruitment of participants
To recruit the members of the steering committee (coordinators)
presidents of the societies involved in diagnostics, therapy,
and follow-up of pancreatic carcinoma were asked to
name two representatives. After voting on the topics, the naming
and invitation of task force members was performed together
with the coordinators (l " Table 1). Participants were doctors
from various care levels who work in hospitals and private
practices. They represented the key disciplines that are relevant
for pancreatic carcinoma: internal medicine (gastroenterology,
hematology-oncology), surgery (visceral surgery), radiooncology,
pathology, diagnostic radiology, palliative medicine,
pain therapy, dietary medicine, psychotherapy-psychosomatics,
laboratory medicine, and epidemiology. The patients’ representative
was appointed by the Task Force of the Pancreatectomized
Patients e. V. Dormagen.
Organizational procedure
Following the voting on the topics with the coordinators, the
list of questions was generated and the search terms for the
literature search were defined (time course l " Table 2). Afterwards
the list of questions and the search terms were revised
and amended by the task forces. A systematic literature
search according to defined search terms was done in
PubMed/Medline for the period from 1995 to May 2006 (inclusive).
The search terms that were used are listed in the
appendix. A total of 42345 citations were viewed (l " Table 3)
and appendix (l " Table 10). 1409 were chosen according to
the following criteria: investigations in humans, original arti-
Adler G et al. S3-Guideline “Exocrine Pancreatic… Z Gastroenterol 2008; 46: 449–482
Table 1 Task forces
1. Risk factors/screening/risk groups
chairmen
S.C. Bischoff Universität Hohenheim, Lehrstuhl für Ernährungsmedizin
und Prävention, Stuttgart
S. Hahn Knappschaftskrankenhaus, Medizinische Universitätsklinik,
Bochum
R. Schmid Klinikum rechts der Isar der TU, II. Medizinische
Klinik und Poliklinik, München
members
G. Adler Universitätsklinikum, Zentrum für Innere Medizin,
Klinik für Innere Medizin I, Ulm
A. Aschoff Universitätsklinikum, Klinik für Diagnostische und
Interventionelle Radiologie, Ulm
I. Bergheim Universität Hohenheim, Lehrstuhl für Ernährungsmedizin
und Prävention, Stuttgart
T. Gress Universitätsklinikum Giessen und Marburg GmbH,
Klinik für Innere Medizin, SP Gastroenterologie,
Endokrinologie und Stoffwechsel, Marburg
V. Keim Universitätsklinikum, Medizinische Klinik und Poliklinik
II, Leipzig
M. Lerch Universitätsklinikum, Klinik und Poliklinik für Innere
Medizin A, Greifswald
J. Lüttges Klinikum Saarbrücken, Pathologisches Institut,
Saarbrücken
G. Nagel Universität Ulm, Institut für Epidemiologie, Ulm
H. Rieder Universitätsklinikum, Institut für Humangenetik
und Anthropologie, Düsseldorf
2. Diagnostics
chairmen
H.-J. Brambs Universitätsklinikum, Klinik für Diagnostische und
Interventionelle Radiologie, Ulm
K. Schlottmann Katharinen-Hospital gGmbH, Innere Klinik I, Unna
B. Wiedenmann CharitØ Universitätsmedizin, CharitØCentrum 13,
Medizinische Klinik mit SP Hepatologie und Gastroenterologie,
Campus Virchow, Berlin
members
M. Dobritz Klinikum rechts der Isar der TU, Institut für Rçntgendiagnostik,
München
P. Mçller Universitätsklinikum, Comprehensive Cancer
Center, Institut für Pathologie, Ulm
J. Mçssner Universitätsklinikum, Zentrum für Innere Medizin,
Medizinische Klinik und Poliklinik II; Gastroenterologie
und Hepatologie, Leipzig
S.T. Post Universitätsklinikum gGmbH, Chirurgische Klinik,
Mannheim
S.N. Reske Universitätsklinikum, Klinik für Nuklearmedizin,
Ulm
J.F.Riemann Klinikum der Stadt Ludwigshafen am Rhein
gGmbH, Medizinische Klinik C, Ludwigshafen
T. Rçsch CharitØ Universitätsmedizin, CharitØCentrum 13,
Medizinische Klinik mit SP Hepatologie und Gastroenterologie,
Zentrale interdisziplinäre Endoskopie,
Campus Virchow, Berlin
A.-O. Schäfer Universitätsklinikum, Radiologische Universitätsklinik,
Rçntgendiagnostik, Freiburg
W. Uhl St. Josef-Hospital, Klinikum der Ruhr-Universität,
Klinik für Chirurgie, Bochum
C. Wagener Universitätsklinikum, Institut für Klinische Chemie/Zentrallaboratorien,
Hamburg-Eppendorf
3. Surgical therapy of pancreatic carcinoma (curative intention)
chairmen
J. Werner Universitätsklinikum, Chirurgische Klinik, Klinik
für Allgemein-, Viszeral- und Transplantationschirurgie,
Heidelberg
W. Hohenberger Chirurgische Klinik mit Poliklinik der Friedrich-
Alexander-Universität Erlangen-Nürnberg, Allgemeine,
Bauch- und Thoraxchirurgie, Erlangen
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