Clinical Practice Guidelines for the management of locally advanced ...

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Dr Carole Pinnock AM Principal research scientist – Repatriation General Hospital, Daw Park SA Emeritus Professor Tom Reeve AC CBE Senior medical advisor, ACN / Convenor, Working Party – Sydney NSW Dr Mark Rosenthal Medical oncologist – Royal Melbourne Hospital, Melbourne VIC Dr Sabe Sabesan Medical oncologist – Townsville Hospital, Townsville QLD A/Professor Tom Shakespeare Radiation oncologist – North Coast Cancer Institute, Coffs Harbour NSW Dr David Smith Epidemiologist – Cancer Council NSW, Sydney NSW Dr Nigel Spry** Radiation oncologist – Sir Charles Gairdner Hospital, Nedlands WA Dr Philip Stricker Urologist – St Vincent’s Clinic, Sydney NSW Professor Christopher Sweeney Medical oncologist – Royal Adelaide Hospital, Adelaide SA Dr Kirsty Wiltshire Radiation oncologist – Peter MacCallum Cancer Centre, Melbourne VIC Dr Agnes Vitry Senior Research Fellow, University of South Australia – Adelaide SA Systematic review team Professor Dianne O’Connell Cancer Council New South Wales, Sydney NSW Dr Louisa Jones Cancer Council New South Wales, Sydney NSW Dr Annette Moxey University of Newcastle, Callaghan NSW Dr David Smith Cancer Council New South Wales, Sydney NSW Ms Suzanne Hughes Cancer Council New South Wales, Sydney NSW Mrs Hayley Griffin Cancer Council New South Wales, Sydney NSW Ms Amy Nolen Cancer Council New South Wales, Sydney NSW Volunteer Dr Marek Czuba Cancer Council New South Wales, Sydney NSW Volunteer Ms Alexandra Hodgkinson Cancer Council New South Wales, Sydney NSW 125 Appendices
Subgroup subcommittees Bisphosphonates Professor Villis Marshall AC Professor Christopher Sweeney Chemotherapy Professor Howard Gurney Professor Ian Olver Professor Mark Rosenthal Dr Sabe Sabesan Complementary and alternative therapies Emeritus Professor Tom Reeve AC CBE Dr Sabe Sabesan Emerging therapies Professor Villis Marshall AC Ms Suzanne Hughes Hormone therapy Professor RA ‘Frank’ Gardiner AM Professor Christopher Sweeney Professor Suzanne Chambers Osteoporosis Professor David Handelsman Palliative care Dr Mary Brooksbank AM A/Professor Mark Boughey Psychosocial Professor Suzanne Chambers Dr Carole Pinnock AM Radiotherapy Dr Joshua Dass Professor Gillian Duchesne** Dr Kumar Gogna Dr Andrew Kneebone A/Professor Jeremy Millar*** A/Professor Tom Shakespeare Dr Kirsty Wiltshire Special reviewer: Dr Lizbeth Kenny, President, Royal Australian and New Zealand College of Radiologists; Radiation Oncologist, Royal Brisbane Hospital Clinical practice guidelines for the management of locally advanced and metastatic prostate cancer 126
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Clinical Practice Guidelines for th
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4 Biochemical relapse .............
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FOREWORD The management of prostate
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SUMMARY OF CLINICAL PRACTICE RECOMM
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SUMMARY OF RECOMMENDATIONS Chapter
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Chapter Recommendations Grade Refs
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1 INTRODUCTION 1.1 Natural history
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2 PSYCHOSOCIAL CARE The diagnosis a
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2.2 Effect of psychological and cog
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Evidence summary Level References T
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Recommendation Men with advanced pr
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An Australian cross-sectional study
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10. Dunn J, et al. A review of peer
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41. Sharpley CF, Christie DRH. An a
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different treatments from different
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Evidence summary Level References I
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Evidence summary Level References F
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Despite these reservations and the
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For non-metastatic disease there we
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Evidence summary Level References T
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monotherapy for low-to-intermediate
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Evidence summary Level References M
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for surgery, suggesting that surger
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Microscopic fully resected node pos
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All three trials demonstrated impro
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Evidence summary Level References B
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of an international multicentre ran
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45. Melton LJ, III, Alothman KI, Kh
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76. Little DJ, Kuban DA, Levy LB, Z
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105. Thompson IM, Tangen CM, Parade
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4.2 Androgen deprivation therapy (e
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Evidence summary Level References F
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therapy since such studies would be
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apparent in trials comparing CAB wi
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QLQ instrument published by Cleary
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Note: Larger well-powered studies h
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Eight trials examined acute toxicit
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half of patients experienced pain r
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olus) in addition to radiotherapy a
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References 1. Seidenfeld J, Samson
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Cooperative Group. Scandinavian Jou
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Oncology Group, TROG 96.05). Radiot
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trial. European Journal of Cancer 1
Page 94 and 95: 6 CASTRATION-RESISTANT PROSTATE CAN
Page 96 and 97: the median overall survival for pat
Page 98 and 99: There are two points regarding bisp
Page 100 and 101: with bone pain at study entry. At n
Page 102 and 103: Recently, there have been reports o
Page 104 and 105: of these studies 56, 58 and in the
Page 106 and 107: Side effects (toxicity) As these ra
Page 108 and 109: hydrocortisone respectively. Tannoc
Page 110 and 111: 5. Manikandan R, Srirangam SJ, Pear
Page 112 and 113: 33. Elomaa I, Kylmala T, Tammela T
Page 114 and 115: 60. Janknegt RA, Abbou CC, Bartolet
Page 116 and 117: physiotherapists, occupational ther
Page 118 and 119: 7.5 Q2: Symptom control There was e
Page 120 and 121: Informal or family caregivers deriv
Page 122 and 123: 8. Hughes SL, Weaver FM, Giobbie-Hu
Page 124 and 125: 8 COMPLEMENTARY AND ALTERNATIVE (UN
Page 126 and 127: corresponding benefit in obstructiv
Page 128 and 129: 3. Eisenberg DM, Kessler RC, Van Ro
Page 130 and 131: areas of the state were more likely
Page 132 and 133: 8 Miller DC, Litwin MS, Bergman J,
Page 134 and 135: 10 EMERGING THERAPIES It is impossi
Page 136 and 137: APPENDIX 1 GUIDELINE DEVELOPMENT PR
Page 138 and 139: study type. Studies published befor
Page 140 and 141: Grade of recommendation Description
Page 142 and 143: 2. National Health and Research Cou
Page 146 and 147: Surgery Professor Villis Marshall A
Page 148 and 149: APPENDIX 3 TNM CLASSIFICATION OF PR
Page 150 and 151: Summary Prostate T1 T2 T3 T4 N1 M1a
Page 152 and 153: APPENDIX 4 ABBREVIATIONS AND GLOSSA
Page 154 and 155: Glossary Actuarial survival A metho
Page 156 and 157: Effectiveness The extent to which a
Page 158 and 159: Lymph nodes Small, generally pea-si
Page 160 and 161: Each stage is divided into subgroup
Page 162 and 163: APPENDIX 6 - ORGANISATIONS WHICH PR
Page 164 and 165: Consultant Urologist, Royal Brisban
Page 166 and 167: No conflict of interest to declare.
Page 168 and 169: Index to Clinical practice guidelin
Page 170 and 171: cardiovascular mortality 19, 54, 55
Page 172 and 173: androgen deprivation therapy (ADT)
Page 174 and 175: and surgery 32-34 survival 18 toxic
Page 176 and 177: and chemotherapy 89-90 see also bon
Page 178 and 179: spinal cord compression 62-63 see a
Page 180 and 181: systemic 141 Tasmania Association f
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