Clinical Practice Guidelines for the management of locally advanced ...

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androgen deprivation therapy (ADT) 51, 52, 53, 56, 57, 58 radiotherapy 61, 62, 63, 64, 65, 66 palliative care 101, 102 pathologic T3/T4 disease post radical surgery 36 psychosocial care 4, 7, 8, 9, 10, 11 radioisotopes 85, 86, 87 evidence-based guidelines 137 exercise 7–9 external beam radiotherapy and bone pain 59–61 locally advanced disease 24–27 node-positive disease 37–38 pathologic T3/T4 disease post radical surgery 34–36 familial cancer services 143 fatigue 19, 20, 55, 99 and physical activity 7–9, 99 five-year survival rate 137 flutamide 54, 55, 56, 57 folinic acid 106 fractures 21–23, 60–61 gastrointestinal disturbances 19, 20, 55, 56, 90 general anaesthetic 137 Gleason score 1, 134, 137 glossary 135–141 grades 137 histopathological 130 green tea extract 115 Guideline Assessment Reviewer 117 guidelines development process 117–122 evidence-based 134 gynaecomastia 54, 55, 56 haemoglobin levels 56 hazard ratio 134 health professionals, and patients use of complementary and alternative therapies 105 hemibody external beam radiotherapy 65–66 histopathological grading 130 home care in 100 death at 99–100 homosexual men, and sexual function 9 hormone manipulations for castrate resistance disease continuing after hormone refractory 78 evidence summaries 77 recommendations 77, 78 second-line 75–77 hormone refractory prostate cancer bisphosphonates 79–80 and bone pain 82–83 hormone manipulations 78 and radioisotopes 84–88 hormone resistance 138 hormone therapy see androgen deprivation therapy (ADT) 153 Index
hormone-naïve metastatic bone prostate cancer 80 bisphosphonates 66, 79 chemotherapy 88 hormones 138 hospices 97 hospitals in the home 100 stays 99 hot flushes 19, 20, 54, 55, 56, 138 hydrocortisone 76 hyperthermia 138 impotence 138 incidence 1–2, 138 and ethnicity and race 111 and income 110 and rural and remote patients 110–111 and socio-economic status 110 income, and incidence 110 Indigenous people 111 indolent 138 information provision 5 interventions to improve 3–4 and literacy levels 111 information services 3, 143 integrated care, palliative care 96–97 integrative medicine 105 interdisciplinary care 97, 98 interventions 138 iodine 125 27–28 iridium 192 28 Karnofsky performance scale 138 ketoconazole 76 knowledge about prostate cancer, interventions to improve 3–4 LHRH see luteinising hormone releasing hormone (LHRH) libido 138 see also sexual function lifestyle, and quality of life 7–9 ligand inhibitors 20 Lions Australia Prostate Cancer website 143 literacy levels 111 liver abnormalities 54, 56 local anaesthetic 138 locally advanced disease androgen deprivation therapy (ADT) and bone health 21–23 choice of 17–18 combined androgen blockage (CAB) 18, 19 complications 18–21 early versus delayed 16–17 evidence summaries 17, 18, 20, 23, 24, 29, 31, 32, 34 long-term 29, 30–31 quality of life (QOL) 23–24 and radiotherapy 29–31 recommendations 17, 18, 21, 23, 24, 30, 31, 32, 34 short-term 29–31 Clinical practice guidelines for the management of locally advanced and metastatic prostate cancer 154
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Clinical Practice Guidelines for th
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4 Biochemical relapse .............
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FOREWORD The management of prostate
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SUMMARY OF CLINICAL PRACTICE RECOMM
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SUMMARY OF RECOMMENDATIONS Chapter
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Chapter Recommendations Grade Refs
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1 INTRODUCTION 1.1 Natural history
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2 PSYCHOSOCIAL CARE The diagnosis a
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2.2 Effect of psychological and cog
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Evidence summary Level References T
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Recommendation Men with advanced pr
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An Australian cross-sectional study
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10. Dunn J, et al. A review of peer
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41. Sharpley CF, Christie DRH. An a
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different treatments from different
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Evidence summary Level References I
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Evidence summary Level References F
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Despite these reservations and the
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For non-metastatic disease there we
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Evidence summary Level References T
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monotherapy for low-to-intermediate
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Evidence summary Level References M
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for surgery, suggesting that surger
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Microscopic fully resected node pos
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All three trials demonstrated impro
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Evidence summary Level References B
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of an international multicentre ran
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45. Melton LJ, III, Alothman KI, Kh
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76. Little DJ, Kuban DA, Levy LB, Z
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105. Thompson IM, Tangen CM, Parade
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4.2 Androgen deprivation therapy (e
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Evidence summary Level References F
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therapy since such studies would be
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apparent in trials comparing CAB wi
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QLQ instrument published by Cleary
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Note: Larger well-powered studies h
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Eight trials examined acute toxicit
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half of patients experienced pain r
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olus) in addition to radiotherapy a
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References 1. Seidenfeld J, Samson
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Cooperative Group. Scandinavian Jou
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Oncology Group, TROG 96.05). Radiot
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trial. European Journal of Cancer 1
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6 CASTRATION-RESISTANT PROSTATE CAN
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the median overall survival for pat
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There are two points regarding bisp
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with bone pain at study entry. At n
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Recently, there have been reports o
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of these studies 56, 58 and in the
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Side effects (toxicity) As these ra
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hydrocortisone respectively. Tannoc
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5. Manikandan R, Srirangam SJ, Pear
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33. Elomaa I, Kylmala T, Tammela T
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60. Janknegt RA, Abbou CC, Bartolet
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physiotherapists, occupational ther
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7.5 Q2: Symptom control There was e
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Informal or family caregivers deriv
Page 122 and 123: 8. Hughes SL, Weaver FM, Giobbie-Hu
Page 124 and 125: 8 COMPLEMENTARY AND ALTERNATIVE (UN
Page 126 and 127: corresponding benefit in obstructiv
Page 128 and 129: 3. Eisenberg DM, Kessler RC, Van Ro
Page 130 and 131: areas of the state were more likely
Page 132 and 133: 8 Miller DC, Litwin MS, Bergman J,
Page 134 and 135: 10 EMERGING THERAPIES It is impossi
Page 136 and 137: APPENDIX 1 GUIDELINE DEVELOPMENT PR
Page 138 and 139: study type. Studies published befor
Page 140 and 141: Grade of recommendation Description
Page 142 and 143: 2. National Health and Research Cou
Page 144 and 145: Dr Carole Pinnock AM Principal rese
Page 146 and 147: Surgery Professor Villis Marshall A
Page 148 and 149: APPENDIX 3 TNM CLASSIFICATION OF PR
Page 150 and 151: Summary Prostate T1 T2 T3 T4 N1 M1a
Page 152 and 153: APPENDIX 4 ABBREVIATIONS AND GLOSSA
Page 154 and 155: Glossary Actuarial survival A metho
Page 156 and 157: Effectiveness The extent to which a
Page 158 and 159: Lymph nodes Small, generally pea-si
Page 160 and 161: Each stage is divided into subgroup
Page 162 and 163: APPENDIX 6 - ORGANISATIONS WHICH PR
Page 164 and 165: Consultant Urologist, Royal Brisban
Page 166 and 167: No conflict of interest to declare.
Page 168 and 169: Index to Clinical practice guidelin
Page 170 and 171: cardiovascular mortality 19, 54, 55
Page 174 and 175: and surgery 32-34 survival 18 toxic
Page 176 and 177: and chemotherapy 89-90 see also bon
Page 178 and 179: spinal cord compression 62-63 see a
Page 180 and 181: systemic 141 Tasmania Association f
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