Clinical Practice Guidelines for the management of locally advanced ...

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spinal cord compression 62–63 see also brachytherapy radium 223 116 randomised controlled trials 1 registries 115 and socio-economic status 112 receptor activator of nuclear kappa B (RANK) ligand inhibitors 20 recommendations biochemical relapse 49 bisphosphonates 83 chemotherapy 90 complementary and alternative therapies 105, 108 grades of vii, 121 hormone manipulations for castrate resistance disease 77, 78 locally advanced disease androgen deprivation therapy (ADT) 17, 18, 21, 23, 24, 30, 31, 34 radiotherapy 26, 27, 28, 30, 31, 36, 37, 38 surgery 32, 34 metastatic disease androgen deprivation therapy (ADT) 51, 52, 53, 56, 57, 59 radiotherapy 61, 62, 63, 64, 65 palliative care 101–102 pathologic T3/T4 disease post radical surgery 36 psychosocial care 4, 7, 9, 10, 11 radioisotopes 85, 86, 88 summary of ix–xvi rectal examination 136 rectum 140 recurrence 140 references, further 142 referrals, to palliative care 97, 101 regional lymph nodes, classification of 130 reliability (of a test) 140 remission complete 136 partial 139 resection of prostate 48 response 136, 140 retrograde ejaculation 140 risk comprehension 3–4 rosiglitazone 115 rural and remote patients and incidence 110–111 and mortality rates 110–111 palliative care 97 salvage radiotherapy 48 samarium 153 84 and bone metastases 84 and bone pain 84–85 side effects 87–88 scrotum 140 secondary tumours 140 second-line hormone manipulations 75–77 seminal vesicles 140 sexual function 9, 19, 54 159 Index
side effects androgen deprivation therapy (ADT) 18–23, 53–56 bisphosphonates 82–83 castration 18–21 docetaxel 89–90 estramustine 89 radioisotopes 87–88 see also toxicity single men 111 skeletal related events (SRE) 78–79 and bisphosphonates 79–80, 82–83 social support 111 socio-economic aspects 110–112 socio-economic status 112 and incidence 110 and randomised controlled trials 112 sodium clodronate 79, 80, 81, 83 sodium etidronate 81 spinal cord compression and radiotherapy 62–63 steroids 64–65 surgery 63–64 spinal metastases, emerging therapies 116 stage, grouping 130 staging 1, 130-132, 137–138, 140 steroids, spinal cord compression 64–65 stricture 141 strontium 89 84, 116 and bone metastases 84 and bone pain 84–85 and quality of life 86 side effects 87–88 support 141 support services 3, 6, 12, 111, 143 suramin 116 surgery locally advanced disease 31–32, 115 and androgen deprivation therapy (ADT) 32–34 evidence summaries 32, 34, 36 recommendations 32, 34, 36 pathologic T3/T4 disease post radical surgery 34–36 spinal cord compression 63–64 and survival 31–32 see also orchidectomy surgical margins 138 survival actuarial 135 and chemotherapy 89–90 disease free 141 five-year rate 134 locally advanced disease 18, 20 metastatic disease 50–51 prostate cancer specific 139 and radioisotopes 85–86 and second-line hormone manipulations 76 and surgery 31–32 symptoms 98–99 systematic reviews 141 Clinical practice guidelines for the management of locally advanced and metastatic prostate cancer 160
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Clinical Practice Guidelines for th
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4 Biochemical relapse .............
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FOREWORD The management of prostate
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SUMMARY OF CLINICAL PRACTICE RECOMM
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SUMMARY OF RECOMMENDATIONS Chapter
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Chapter Recommendations Grade Refs
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1 INTRODUCTION 1.1 Natural history
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2 PSYCHOSOCIAL CARE The diagnosis a
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2.2 Effect of psychological and cog
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Evidence summary Level References T
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Recommendation Men with advanced pr
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An Australian cross-sectional study
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10. Dunn J, et al. A review of peer
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41. Sharpley CF, Christie DRH. An a
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different treatments from different
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Evidence summary Level References I
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Evidence summary Level References F
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Despite these reservations and the
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For non-metastatic disease there we
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Evidence summary Level References T
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monotherapy for low-to-intermediate
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Evidence summary Level References M
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for surgery, suggesting that surger
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Microscopic fully resected node pos
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All three trials demonstrated impro
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Evidence summary Level References B
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of an international multicentre ran
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45. Melton LJ, III, Alothman KI, Kh
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76. Little DJ, Kuban DA, Levy LB, Z
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105. Thompson IM, Tangen CM, Parade
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4.2 Androgen deprivation therapy (e
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Evidence summary Level References F
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therapy since such studies would be
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apparent in trials comparing CAB wi
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QLQ instrument published by Cleary
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Note: Larger well-powered studies h
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Eight trials examined acute toxicit
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half of patients experienced pain r
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olus) in addition to radiotherapy a
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References 1. Seidenfeld J, Samson
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Cooperative Group. Scandinavian Jou
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Oncology Group, TROG 96.05). Radiot
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trial. European Journal of Cancer 1
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6 CASTRATION-RESISTANT PROSTATE CAN
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the median overall survival for pat
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There are two points regarding bisp
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with bone pain at study entry. At n
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Recently, there have been reports o
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of these studies 56, 58 and in the
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Side effects (toxicity) As these ra
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hydrocortisone respectively. Tannoc
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5. Manikandan R, Srirangam SJ, Pear
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33. Elomaa I, Kylmala T, Tammela T
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60. Janknegt RA, Abbou CC, Bartolet
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physiotherapists, occupational ther
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7.5 Q2: Symptom control There was e
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Informal or family caregivers deriv
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8. Hughes SL, Weaver FM, Giobbie-Hu
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8 COMPLEMENTARY AND ALTERNATIVE (UN
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corresponding benefit in obstructiv
Page 128 and 129: 3. Eisenberg DM, Kessler RC, Van Ro
Page 130 and 131: areas of the state were more likely
Page 132 and 133: 8 Miller DC, Litwin MS, Bergman J,
Page 134 and 135: 10 EMERGING THERAPIES It is impossi
Page 136 and 137: APPENDIX 1 GUIDELINE DEVELOPMENT PR
Page 138 and 139: study type. Studies published befor
Page 140 and 141: Grade of recommendation Description
Page 142 and 143: 2. National Health and Research Cou
Page 144 and 145: Dr Carole Pinnock AM Principal rese
Page 146 and 147: Surgery Professor Villis Marshall A
Page 148 and 149: APPENDIX 3 TNM CLASSIFICATION OF PR
Page 150 and 151: Summary Prostate T1 T2 T3 T4 N1 M1a
Page 152 and 153: APPENDIX 4 ABBREVIATIONS AND GLOSSA
Page 154 and 155: Glossary Actuarial survival A metho
Page 156 and 157: Effectiveness The extent to which a
Page 158 and 159: Lymph nodes Small, generally pea-si
Page 160 and 161: Each stage is divided into subgroup
Page 162 and 163: APPENDIX 6 - ORGANISATIONS WHICH PR
Page 164 and 165: Consultant Urologist, Royal Brisban
Page 166 and 167: No conflict of interest to declare.
Page 168 and 169: Index to Clinical practice guidelin
Page 170 and 171: cardiovascular mortality 19, 54, 55
Page 172 and 173: androgen deprivation therapy (ADT)
Page 174 and 175: and surgery 32-34 survival 18 toxic
Page 176 and 177: and chemotherapy 89-90 see also bon
Page 180 and 181: systemic 141 Tasmania Association f
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