Publikationen - University of Bonn - Medical Center (IMBIE)

Publikationen 

14.01.2013 

In press 

Originalarbeiten: Erst- und Letztautorenschaften 

1. Dodel R, Rominger A, Bartenstein P, Barkhof F, Blennow K, Förster S, Winter Y, Bach JP, 

Popp J, Alferink J, Wiltfang J, Buerger K, Otto M, Antuono P, Jacoby M, Richter R, Stevens J, 

Melamed I, Goldstein J, Haag S, Wietek S, Farlow M, Jessen F. Intravenous immunoglobulins 

for the treatment of mild to moderate Alzheimer’s disease: a phase II, randomised, doubleblind, 

placebo-controlled dose-finding trial. Lancet Neurol. In press IF: 23.462 

2. Jessen F, Wolfsgruber S, Wiese B, Bickel H, Mösch E, Kaduszkiewicz H, Pentzek M, Riedel- 

Heller SG, Luck T, Fuchs A, Weyerer S, Werle J, van den Bussche, Scherer M, Maier W, 

Wagner M, for the AgeCoDe study group. AD dementia risk in late MCI, in early MCI and in 

subjective memory impairment. Alzheimers Dement. In press. IF: 6.373 

2013 

Originalarbeiten: Koautorenschaften 

1. Popp J, Meichsner S, Kölsch H, Lewczuk P, Maier W, Kornhuber J, Jessen F, Lütjohann D. 

2013. Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's 

Disease. Biochem Pharmacol. Online. IF 4.705 

2012 


1. Scheef L, Spottke A, Daerr M, Joe A, Striepens N, Kölsch H, Popp J, Daamen M, Gorris D, 

Heneka MT, Boecker H,. Heneka MT, Boecker H, Biersack HJ, Maier W, Schild HH, Wagner 

M, Jessen F. Glucose metabolism, gray matter structure and memory decline in subjective 

memory impairment. Neurology. 79:1332-1339. 2012. IF: 8.312

Professor Dr. med. Frank Olaf Jessen 

2. Lewczuk P, Popp J, Lelental N, Kölsch H, Maier W, Kornhuber J, Jessen F. Cerebrospinal fluid 

soluble amyloid-β protein precursor as a potential novelbiomarkers of Alzheimer's disease. J 

Alzheimers Dis. 28:119-125. 2012. IF: 3.745 


1. Besong-Agbo D, Wolf E, Jessen F, Oechsner M, Hametner E, Poewe W, Reindl M, Oertel WH, 

Noelker C, Bacher M, Dodel R. Naturally occurring α-synuclein autoantibody levels are lower in 

patients with Parkinson disease. Neurology. Online. 2012. IF: 8.312 

2. Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, 

Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas 

C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, BrayneC, Rubinsztein 

DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, 

Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox 

N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den 

Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, 

Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, 

Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary 

IJ, Al-Chalabi A, ShawCE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, 

Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, 

Jones L, Holmans PA, O'Donovan MC, Owen MJ, Williams J. The role of variation at AβPP, 

PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis. 28:377-387. 

2012. IF: 3.745 

3. Kummer M, Vogl T, Axt D, Griep A, Viera-Saecker A, Jessen F, Gelpi E, Roth J, Heneka M. 

Mrp14 deficiency ameliorates Aß03B2; burden by increasing microglial phagocytosis and 

modulation of APP processing. J Neurosci. 32:17824-17829. 2012. IF: 7.115 

4. Semmler A, Widmann CN, Okulla T, Urbach H, Kaiser M, Widman G, Mormann F, Weide J, 

Fliessbach K, Hoeft A, Jessen F, Putensen C, Heneka MT. Persistent cognitive impairment, 

hippocampal atrophy and EEG changes in sepsis survivors. J Neurol Neurosurg Psychiatry. 

Online. 2012. IF: 4.764 

5. van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Theuns J, Engelborghs S, Philtjens S, 

Vandenbulcke M, Sleegers K, Sieben A, Bäumer V, Maes G, Corsmit E, Borroni B, Padovani 

A, Archetti S, Perneczky R, Diehl-Schmid J, de Mendonça A, Miltenberger-Miltenyi G, Pereira 

S, Pimentel J, Nacmias B, Bagnoli S, Sorbi S, Graff C, Chiang HH, Westerlund M, Sanchez- 

2


Valle R, Llado A, Gelpi E, Santana I, Almeida MR, Santiago B, Frisoni G, Zanetti O, Bonvicini 

C, Synofzik M, Maetzler W, Vom Hagen JM, Schöls L, Heneka MT, Jessen F, Matej R, 

Parobkova E, Kovacs GG, Ströbel T, Sarafov S, Tournev I, Jordanova A, Danek A, Arzberger 

T, Fabrizi GM, Testi S, Salmon E, Santens P, Martin JJ, Cras P, Vandenberghe R, De Deyn 

PP, Cruts M, Van Broeckhoven C; on behalf of the European Early-Onset Dementia (EOD) 

Consortium. A Pan-European study of the C9orf72 Repeat Associated with FTLD: Geographic 

Prevalence, Genomic Instability and Intermediate Repeats. Hum Mutat. Online. 2012. IF: 5.686 

6. Smith DE, Smulders YM, Blom HJ, Popp J, Jessen F, Semmler A, Farkas M, Linnebank M. 

Determinants of the essential one-carbon metabolism metabolites, homocysteine, Sadenosylmethionine, 

S-adenosylhomocysteine and folate, in cerebrospinal fluid. Clin Chem 

Lab Med. 50:1641-1647. 2012. IF: 2.150 

7. Popp J, Lewczuk P, Kölsch H, Meichsner S, Maier W, Kornhuber J, Jessen F, Lütjohann D. 

Cholesterol metabolism is associated with soluble amyloid precursor protein production in 

Alzheimer's disease. J Neurochem. 123:310-316. 2012. IF: 4.061 

8. Luppa M, Riedel-Heller SG, Stein J, Leicht H, König HH, van den Bussche H, Maier W, 

Scherer M, Bickel H, Mösch E, Werle J, Pentzek M, Fuchs A, Eisele M, Jessen F, Tebarth F, 

Wiese B, Weyerer S; AgeCoDe study group. Predictors of institutionalisation in incident 

dementia--results of the German Study on Ageing, Cognition and Dementia in Primary Care 

Patients (AgeCoDe study). Dement Geriatr Cogn Disord. 33:282-288. 2012. IF: 2.141 

9. Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F, Böger RH, 

Popp J. Dimethylarginines, Homocysteine Metabolism, and Cerebrospinal Fluid Markers for 

Alzheimer's Disease. J Alzheimers Dis. 31:751-758. 2012. IF: 3.745 

10. Luck T, Luppa M, Wiese B, Maier W, van den Bussche H, Eisele M, Jessen F, Weeg D, 

Weyerer S, Pentzek M, Leicht H, Koehler M, Tebarth F, Olbrich J, Eifflaender-Gorfer S, Fuchs 

A, Koenig HH, Riedel-Heller SG; for the AgeCoDe Study Group. Prediction of Incident 

Dementia: Impact of Impairment in Instrumental Activities of Daily Living and Mild Cognitive 

Impairment – Results From the German Study on Ageing, Cognition, and Dementia in Primary 

Care Patients. Am J Geriatr Psychiatry. Online. 2012. IF: 3.638 

11. Köhler M, Kliegel M, Kaduszkiewicz H, Bachmann C, Wiese B, Bickel H, Mösch E, Weyerer S, 

Werle J, Fuchs A, Pentzek M, Leicht H, König HH, Luppa M, Riedel-Heller S, Jessen F, Maier 

W, Scherer M, Wagner M; for the Ageing, Cognition and Dementia in Primary Care Patients 

(AgeCoDe) study group. Effect of Cardiovascular and Metabolic Disease on Cognitive Test 

Performance and Cognitive Change in Older Adults. J Am Geriatr Soc. Online. 2012. IF: 3.737 

3


12. Schuhmacher A, Mössner R, Jessen F, Scheef L, Block W, Belloche AC, Lennertz L, Welper 

H, Höfels S, Pfeiffer U, Wagner M, Maier W, Schwab S, Zobel A. Association of amygdala 

volumes with cortisol secretion in unipolar depressed patients. Psychiatry Res. Online. 2012. 

IF: 2.964 

13. Peters O, Lorenz D, Fesche A, Schmidtke K, Hüll M, Perneczky R, Rüther E, Möller HJ, 

Jessen F, Maier W, Kornhuber J, Jahn H, Luckhaus C, Gertz HJ, SchröderJ, Pantel J, Teipel 

S, Wellek S, Frölich L, Heuser I. A Combination of Galantamine and Memantine Modifies 

Cognitive Function in Subjects with Amnestic MCI. J Nutr Health Aging. 16:544-548. 2012. IF: 

2.686 

14. Zimmermann T, Kaduszkiewicz H, vd Bussche H, Schön G, Wegscheider K, Werle J, Weyerer 

S, Wiese B, Olbrich J, Weeg D, Riedel-Heller S, Luppa M, Jessen F, Abholz HH, Maier W, 

Pentzek M. Reliabilität ärztlicher Morbiditätsangaben zu chronischen Krankheiten. 

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 55:260-269. 2012. IF: 

0.658 

15. Wagner M, Wolf S, Reischies FM, Daerr M, Wolfsgruber S, Jessen F, Popp J, Maier W, Hüll 

M, Frölich L, Hampel H, Perneczky R, Peters O, Jahn H, Luckhaus C, Gertz HJ, Schröder J, 

Pantel J, Lewczuk P, Kornhuber J, Wiltfang J. Biomarker validation of a cued recall memory 

deficit in prodromal Alzheimer disease. Neurology. 78:379-386. 2012. IF: 8.312 

16. Schrijvers EM, Schürmann B, Koudstaal PJ, van den Bussche H, Van Duijn CM, Hentschel F, 

Heun R, Hofman A, Jessen F, Kölsch H, Kornhuber J, Peters O, Rivadeneira F, Rüther E, 

Uitterlinden AG, Riedel-Heller S, Dichgans M, WiltfangJ, Maier W, Breteler MM, Ikram MA. 

Genome-wide association study of vascular dementia. Stroke. 43:315-319. 2012. IF: 5.729 

Originalarbeiten: Mitglied in Autorengruppen 

1. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N, 

Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill 

M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass NJ, 

Gurling H, McQuillin A; the GERAD Consortium; the National Institute on Aging Late-Onset 

Alzheimer's Disease Family Study Group, Holmans P, Jones L, Devlin B, Klei L, Barmada MM, 

Demirci FY, Dekosky ST, Lopez OL, Passmore P, Owen MJ, O'Donovan MC, Mayeux R, 

Kamboh MI, Williams J. Genome-wide association study of Alzheimer's disease with psychotic 

symptoms. Mol Psychiatry. 17:1316-1327. 2012. IF: 13.668 

4


2. Chapman J, Rees E, Harold D, Ivanov D, Gerrish A, Sims R, Hollingworth P, Stretton A, 

GERAD1 Consortium, Holmans P, Owen MJ, O’Donovan MC, Williams J, Kirov G. A genomewide 

study shows a limited contribution of rare copy number variants to Alzheimer’s disease 

risk. Hum Mol Genet. Online. 2012. IF: 7.636 

3. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, 

Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, 

Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, 

Hardy J; the Alzheimer Genetic Analysis Group. TREM2 Variants in Alzheimer's Disease. N 

Engl J Med. Online. 2012. IF: 53.298 

4. Hamilton G, Harris SE, Davies G, Liewald DC, Tenesa A, Payton A, Horan MA, Ollier WE, 

Pendleton N; Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) 

Consortium, Starr JM, Porteous D, Deary IJ. The role of ECE1 variants in cognitive ability in 

old age and Alzheimer's disease risk. Am J Med Genet B Neuropsychiatr Genet. 159B:696- 

709. 2012. IF: 3.705 

5. Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, 

Lovestone S, Goate A, Younkin S, Passmore P; Genetic and Environmental Risk for 

Alzheimer's Disease Consortium, Morgan K; Alzheimer's Research UK Consortium. Genetic 

variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide 

association studies (GWAS). Neurobiol Aging. 33:1849.e5-18. 2012. IF: 6.189 

6. Hudson G, Sims R, Harold D, Chapman J, Hollingworth P, Gerrish A, Russo G, Hamshere M, 

Moskvina V, Jones N, Thomas C, Stretton A, Holmans PA, O'Donovan MC, Owen MJ, Williams 

J, Chinnery PF; GERAD1 Consortium. No consistent evidence for association between 

mtDNA variants and Alzheimer disease. Neurology. 78:1038-1042. 2012. IF: 8.312 

7. Eisele M, Zimmermann T, Köhler M, Wiese B, Heser K, Tebarth F, Weeg D, Olbrich J, Pentzek 

M, Fuchs A, Weyerer S, Werle J, Leicht H, König HH, Luppa M, Riedel-Heller S, Maier W, 

Scherer M; AgeCoDe Study Group. Influence of social support on cognitive change and 

mortality in old age: results from the prospective multicentre cohort study AgeCoDe. BMC 

Geriatr. 12:9. 2012. kein IF 

8. Stein J, Luppa M, Maier W, Tebarth F, Heser K, Scherer M, Zimmermann T, Eisele M, Bickel 

H, Mösch E, Weyerer S, Werle J, Pentzek M, Fuchs A, Wiese B, Prokein J, König HH, Leicht 

H, Riedel-Heller SG; AgeCoDe Study Group. The assessment of changes in cognitive 

functioning in the elderly: age- and education-specific reliable change indices for the SIDAM. 

Dement Geriatr Cogn Disord. 33:73-83. 2012. IF: 2.141 

5


9. Hamilton G, Killick R; Genetic and Environmental Risk for Alzheimer's Disease 

Consortium; Translational Genomics Research Institute Consortium, Lambert JC, Amouyel P; 

European Alzheimer Disease Initiative, Carrasquillo MM, Pankratz VS, Graff-Radford NR, 

Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic 

analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging. 

33:1848.e1-13. 2012. IF: 6.189 

10. Stein J, Luppa M, Maier W, Wagner M, Wolfsgruber S, Scherer M, Köhler M, Eisele M, 

Weyerer S, Werle J, Bickel H, Mösch E, Wiese B, Prokein J, Pentzek M, Fuchs A, Leicht H, 

König HH, Riedel-Heller SG; AgeCoDe Study Group (Mitglied der Autorengruppe). 

Assessing cognitive changes in the elderly: reliable change indices for the Mini-Mental State 

Examination. Acta Psychiatr Scand. 126:208-218. 2012. IF: 4.220 

11. Forstmeier S, Maercker A, Maier W, van den Bussche H, Riedel-Heller S, Kaduszkiewicz H, 

Pentzek M, Weyerer S, Bickel H, Tebarth F, Luppa M, Wollny A, Wiese B, Wagner M; 

AgeCoDe Study Group. Motivational reserve: motivation-related occupational abilities and risk 

of mild cognitive impairment and Alzheimer disease. Psychol Aging. 27:353-363. 2012. IF: 

2.729 

12. Luppa M, Riedel-Heller SG, Luck T, Wiese B, van den Bussche H, Haller F, Sauder M, Mösch 

E, Pentzek M, Wollny A, Eisele M, Zimmermann T, König HH, Maier W, Bickel H, Werle J, 

Weyerer S; AgeCoDe study group. Age-related predictors of institutionalization: results of the 

German study on ageing, cognition and dementia in primary care patients (AgeCoDe). Soc 

Psychiatry Psychiatr Epidemiol. 47:263-270. 2012. IF: 2.696 

Deutschsprachige Publikationen (nicht in Pubmed gelistet) 

1. Jessen F. Alzheimer Demenz. Nicht medikamentöse Therapie im Fokus. Info Neurologie & 

Psychiatrie. 6:50-54. 2012. 

2. Haupt M, Adler G, Bohlken J, Reischies FM, Eckert A, Walbert H, Jessen F. Subjektive 

Gedächtnisstörung: Ein Aufruf zum aktiven Management älterer Patienten, die in der ärztlichen 

Praxis über nachlassende Gedächtnisleistung klagen. Neurotransmitter. 23, Beilage „Medizin 

Forum“:1-8. 2012. 

3. Jessen F. Therapie der Demenz: State of the Art Demenzerkrankungen. Exzellenzforschung in 

der Medizin. 2:60-65. 2012. 

6


2011 


1. Jessen F, Fingerhut N, Sprinkart AM, Kühn KU, Petrovsky N, Maier W, Schild HH, Block W, 

Wagner M, Träber F. N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in 

Patients With Schizophrenia. Schizophr Bull. Online. 2011. IF: 8.800 

2. Jessen F, Lewczuk P, Gür O, Block W, Ende G, Frölich L, Hammen T, Arlt S, Kornhuber J, 

Kucinski T, Popp J, Peters O, Maier W, Träber F, Wiltfang J. Association of N-acetylaspartate 

and cerebrospinal fluid Aβ42 in dementia. J Alzheimers Dis. 27:393-399. 2011. IF: 3.745 

3. Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F. Evidence of neuronal 

compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry. 

68:845-852. 2011. IF: 12.016 

4. Schürmann B, Wiese B, Bickel H, Weyerer S, Riedel-Heller SG, Pentzek M, Bachmann C, 

Williams J, van den Bussche H, Maier W, Jessen F. Association of the Alzheimer's disease 

clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis. 25:421-424. 2011. IF: 

3.745 

5. Jessen F, Wiese B, Bickel H, Eiffländer-Gorfer S, Fuchs A, Kaduszkiewicz H, Köhler M, Luck 

T, Mösch E, Pentzek M, Riedel-Heller SG, Wagner M, Weyerer S, Maier W, van den Bussche 

H; AgeCoDe Study Group. Prediction of dementia inprimary care patients. PLoS One. 

6:e16852. 2011. IF: 4.092 

6. Striepens N, Scheef L, Wind A, Meiberth D, Popp J. Spottke A, Kölsch H, Wagner M, Jessen 

F. Interaction effects of subjective memory impairment and ApoE4 genotype On episodic 

memory and hippocampal volume. Psychol Med. 41:1977-2006. 2011. IF: 6.159 


1. Papassotiropoulos A, Henke K, Stefanova E, Aerni A, Müller A, Demougin, P, Vogler C, 

Sigmund JC, Gschwind L, Huynh KD, Coluccia D, Mandodori CR, Hänggi J, Buchmann A, 

Kostic V, Novakovic I, van den Bussche H, Kaduszkiewicz H, Weyerer S, Bickel H, Riedel- 

Heller S, Pentzek M, Wiese B, Dichgans M, Wagner M, Jessen F, Maier W, de Quervain DJF. 

A genome-wide survey of human short-term memory. Mol Psychiatry. 16:184-192. 2011. IF: 

13.668 

7


2. Teipel SJ, Reuter S, Stieltjes B, Acosta-Cabronero J, Ernemann U, FellgiebelA, Filippi M, 

Frisoni G, Hentschel F, Jessen F, Klöppel S, Meindl T, Pouwels PJ, Hauenstein KH, Hampel 

H. Multicenter stability of diffusion tensor imagingmeasures: a European clinical and physical 

phantom study. Psychiatry Res. 194:363-371. 2011. IF: 2.964 

3. Voigt-Radloff S, Graff M, Leonhart R, Schornstein K, Jessen F, Bohlken J, MetzB, Fellgiebel A, 

Dodel R, Eschweiler G, Vernooij-Dassen M, Olde Rikkert M, Hüll M. A multicentre RCT on 

community occupational therapy in Alzheimer's disease: 10sessions are not better than one 

consultation. BMJ Open. 1:e000096. 2011. kein IF 

4. Teipel SJ, Peters O, Heuser I, Jessen F, Maier W, Froelich L, Arlt S, Hüll M, Gertz HJ, 

Kornhuber J, Wiltfang J, Thome J, Rienhoff O, Meindl T, Hampel H, Grothe M. Atrophy 

outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and 

analysis approaches on sample sizes. World J Biol Psychiatry. 12 Suppl 1:109-113. 2011. IF: 

2.385 

5. Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape 

HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine 

10 critically enhances amyloid β aggregation and plaque formation. Neuron. 71:833-844. 2011. 

IF: 14.736 

6. Reese JP, Hessmann P, Seeberg G, Henkel D, Hirzmann P, Rieke J, Baum E, Dannhoff F, 

Müller MJ, Jessen F, Geldsetzer MB, Dodel R. Cost and care of patients with Alzheimer's 

disease: clinical predictors in German health care settings. J Alzheimers Dis. 27:723-736. 

2011. IF: 3.745 

7. Schipke CG, Jessen F, Teipel S, Luckhaus C, Wiltfang J, Esselmann H, Frölich L, Maier W, 

Rüther E, Heppner FL, Prokop S, Heuser I, Peters O. Long-term stability of Alzheimer's 

disease biomarker proteins in cerebrospinal fluid. J Alzheimers Dis. 26:255-262. 2011. IF: 

3.745 

8. Frings L, Klöppel S, Teipel S, Peters O, Frölich L, Pantel J, Schröder J, Gertz HJ, Arlt S, 

Heuser I, Kornhuber J, Wiltfang J, Maier W, Jessen F, Hampel H, Hüll M. Left anterior 

temporal lobe sustains naming in Alzheimer's dementia and mild cognitive impairment. Curr 

Alzheimer Res. 8:893-901. 2011. IF: 3.953 

9. Vanmierlo T, Popp J, Kölsch H, Friedrichs S, Jessen F, Stoffel-Wagner B, Bertsch T, 

Hartmann T, Maier W, von Bergmann K, Steinbusch H, Mulder M, Lütjohann D. The plant 

sterol brassicasterol as additional CSF biomarker in Alzheimer's disease. Acta Psychiatr 

Scand. 24:184-192. 2011. IF: 4.220 

8


10. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, 

Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards 

A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne 

C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness 

B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe 

PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen 

F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, 

Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate 

AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, 

Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin 

A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, 

Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, 

Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen 

RC; Alzheimer's Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA, 

DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S; CHARGE consortium, Berr C, 

Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M; EADI1 

consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, 

Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, 

Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, 

Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, 

Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù 

P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, 

Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, 

Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J. Common variants at ABCA7, 

MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat 

Genet. 43:429-435. 2011. IF: 35.532 


1. Leicht H, Heinrich S, Heider D, Bachmann C, Bickel H, van den Bussche H, Fuchs A, Luppa M, 

Maier W, Mösch E, Pentzek M, Rieder-Heller SG, Tebarth F, Werle J, Weyerer S, Wiese B, 

Zimmermann T, König HH; AgeCoDe study group. Net costs of dementia by disease stage. 

Acta Psychiatr Scand. 124:384-395. 2011. IF: 4.220 

2. Weyerer S, Schäufele M, Wiese B, Maier W, Tebarth F, van den Bussche H, Pentzek M, Bickel 

H, Luppa M, Riedel-Heller SG; German AgeCoDe Study group (German Study on Ageing, 

Cognition and Dementia in Primary Care Patients). Current alcohol consumption and its 

9


relationship to incident dementia: results from a 3-year follow-up study among primary care 

attenders aged 75 years and older. Age Ageing. 40:456-463. 2011. IF: 3.090 

3. Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, 

Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M, 

Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines 

JL, Younkin S, Williams J, van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R; 

Genetic and Environmental Risk in Alzheimer Disease 1 Consortium. Meta-analysis of the 

association between variants in SORL1 and Alzheimer disease. Arch Neurol. 68:99-106. 2011. 

IF: 7.584 

4. Koehler M, Kliegel M, Wiese B, Bickel H, Kaduszkiewicz H, van den Bussche H, Eifflaender- 

Gorfer S, Eisele M, Fuchs A, Koenig HH, Leicht H, Luck T, Maier W, Moesch E, Riedel-Heller 

S, Tebarth F, Wagner M, Weyerer S, Zimmermann T, Pentzek M; AgeCoDe study group. 

Malperformance in verbal fluency and delayed recall as cognitive risk factors for impairment in 

instrumental activities of daily living. Dement Geriatr Cogn Disord. 31:81-88. 2011. IF: 2.141 

Übersichtsarbeiten 

1. Hampel H, Prvulovic D, Teipel S, Jessen F, Luckhaus C, Frölich L, Riepe MW, Dodel R, Leyhe 

T, Bertram L, Hoffmann W, Faltraco F; German Task Force on Alzheimer's Disease (GTF-AD). 

The future of Alzheimer's disease: the next 10 years. Prog Neurobiol. 95:718-728. 2011. IF: 

8.874 


1. Jessen F. Diagnostischer Nihilismus ist nicht angesagt. Ärztliches Journal Reise & Medizin / 

Neurologie/Psychiatrie. 12:28-30. 2011. 

2. Jessen F. Therapie der Demenz. Psychiatrie und Psychotherapie up2date. 3: 141-147. 2011. 

3. Jessen F. Diagnostik der Demenz. Psychiatrie und Psychotherapie up2date. 1:9-15. 2011. 

Buchbeiträge 

10


1. Maier W, Jessen F. Prospective studies: Aids to establish early and accurate dementia 

diagnoses. In: Versorgungsforschung für demenziell erkrankte Menschen, Eds. Dibelius O, 

Maier W. Kohlhammer GmbH Stuttgart. 18-23. 2011. ISBN: 978-3-17-021331-9 

2010 


1. Popp J, Lewczuk P, Frommann I, Kölsch H, Kornhuber J, Maier W, Jessen F. Cerebrospinal 

fluid markers for Alzheimer's disease over the lifespan: effects ofage and the APOEε4 

genotype. J Alzheimers Dis. 22:459-468. 2010. IF: 3.745 

2. Jessen F, Kaduszkiewicz H, Daerr M, Bickel H, Pentzek M, Riedel-Heller S, Wagner M, 

Weyerer S, Wiese B, van den Bussche H, Broich K, Maier W. Anticholinergic drug use and risk 

for dementia: target for dementia prevention. Eur Arch Psychiatry Clin Neurosci. 260 Suppl 

2:S111-115. 2010. IF: 3.494 

3. Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, 

Blom H, Stoffel-Wagner B, Kölsch H, Weller M, Jessen F. S-adenosylmethionine is decreased 

in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 7:373-378. 

2010. IF: 3.056 

4. Scheef L, Manka C, Daamen M, Kühn KU, Maier W, Schild HH, Jessen F. Resting state 

perfusion in unmedicated schizophrenic patients-A CASL study at 3.0T. Radiology. 256:253- 

260. 2010. IF: 5.726 

5. Jessen F, Wiese B, Bachmann C, Eifflaender-Gorfer S, Haller F, Kölsch H, Luck T, Mösch E, 

Kaduszkiewicz H, Wagner M, Wollny A, Pentzek M, Riedel-Heller SG, Weyerer S, van den 

Bussche H, Maier W, Bickel H. Prediction of dementia by subjective memory impairment – 

effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry. 

67:414-422. 2010. IF: 12.016 

6. Striepens N, Scheef l L, Wind A, Popp J, Spottke A, Suliman H, Wagner M, Schild HH, Jessen 

F. Volume loss of the medial temporal lobe structures in subjective memory impairment. 

Dement Geriatr Cogn Disord. 29:75-81. 2010. IF: 2.141 

11



1. Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, PocklingtonA, 

Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, 

Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, 

Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, 

Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, 

Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, 

Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, 

Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, 

McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, 

Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, 

Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J. 

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of 

Alzheimer's disease. PLoS One. 5:e13950. 2010. IF: 4.092 

2. Kaduszkiewicz H, Zimmermann T, van den Bussche H, Bachmann C, Wiese B, Bickel H, 

Mösch E, Romberg HP, Jessen F, Cvetanovska-Pllashniku G, Maier W, Riedel-Heller SG, 

Luppa M, Sandholzer H, Weyerer S, Mayer M, Hofmann A, Fuchs A, Abholz HH, Pentzek M fot 

the AgeCoDe study group. Do general practioners recognize mild cognitive impairment in their 

patients? J Nutr Health Aging. 14:697-702. 2010. IF: 2.686 

3. Teipel SJ, Ewers M, Wolf S, Jessen F, Kölsch H, Arlt S, Luckhaus C, Schönknecht P, 

Schmidtke K, Heuser I, Frölich L, Ende G, Pantel J, Wiltfang J, Rakebrandt F, Peters O, Born 

C, Kornhuber J, Hampel H. Multicentre variability of MRI-based medial temporal lobe volumetry 

in Alzheimer's disease. Psychiatry Res. 182:244-250. 2010. IF: 2.964 

4. Webster J, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, 

Craig DW, Coon KD, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem 

M, Mastroeni D, Grover A, Rogers J, Heun R, Jessen F, Kölsch H, Heward CB, Ravid R, 

Hutton ML, Melquist S, Petersen RC, Caselli RJ, Papassotiropoulos A, Stephan DA, Hardy J, 

Myers A. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's 

disease and fails to replicate most candidates from Meta-analysis. Int J Mol Epidemiol Genet. 

1:19-30. 2010. kein IF 

5. Kölsch H, Heun R, Jessen F, Popp J, Hentschel F, Maier W, Lütjohann D. Alterations of 

cholesterol precursor levels in Alzheimer's disease. Biochim Biophys Acta. 1801:945-950. 

2010. IF: 5.269 

12


6. Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese 

JP, Al-Abed Y, Dodel R. The Role of Macrophage Migration Inhibitory Factor in Alzheimer’s 

Disease. Mol Med. 16:116-121. 2010. IF: 3.757 

7. Pentzek M, Wollny A, Wiese B, Jessen F, Haller F, Maier W, Riedel-Heller SG, Angermeyer 

MC, Bickel H, Mösch E, Weyerer S, Werle J, Bachmann C, Zimmermann T, van den Bussche 

H, Abholz HH, Fuchs A; AgeCoDe Study Group. Apart from nihilism and stigma: what 

influences general practitioners' accuracy in identifying incident dementia? Am J Geriatr 

Psychiatry. 17:965-975. 2010. IF: 3.638 

8. Lewczuk P, Kornhuber J, Vanmechelen E, Peters O, Heuser I, Maier W, Jessen F, Bürger K, 

Hampel H, Frölich L, Henn F, Falkai P, Rüther E, Jahn H, Luckhaus C, Perneczky R, 

Schmidtke K, Schröder J, Kessler H, Pantel J, Gertz HJ, Vanderstichele H, De Meyer G, 

Shapiro F, Wolf S, Bibl M, Wiltfang J. Amyloid beta peptides in plasma in early diagnosis of 

Alzheimer's disease: a multicenter study with multiplexing. Exp Neurol. 223:366-367. 2010. IF: 

4.699 

9. Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, 

Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H, 

Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, 

Kornhuber J, Wiltfang J. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel 

potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry. 15:138-145. 

2010. IF: 13.668 


1. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith 

AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, 

Longstreth WT Jr, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T, 

Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez 

C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, 

Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, 

Auerbach S, Rice K, Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty 

BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf 

PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM; CHARGE Consortium; GERAD1 

Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci associated with 

Alzheimer disease. JAMA. 303:1832-1840. 2010. IF: 30.026 

13


2. Luck T, Riedel-Heller SG, Luppa M, Wiese B, Wollny A, Wagner M, Bickel H, Weyerer S, 

Pentzek M, Haller F, Moesch E, Werle J, Eisele M, Maier W, van den Bussche H, 

Kaduszkiewicz H; AgeCoDe Study Group. Risk factors for incident mild cognitive impairmentresults 

from the German Study on Ageing, Cognition and Dementia in Primary Care Patients 

(AgeCoDe). Acta Psychiatr Scand. 121:260-272. 2010. IF: 4.220 


1. Jessen F. Stellungnahme zur S3-Leitlinie Demenzen der DGPPN und der DGN aus 

psychiatrischer Sicht. Fortschr Neurol Psychiatr. 78:509-512. 2010. IF: 0.741 

2. Maier W, Jessen F. Evidenzbasierte Standards für die Versorgung von Patienten mit 

Demenzen. Nervenarzt. 81:795. 2010. IF: 0.681 

3. Jessen F, Spottke A. Therapie von psychischen und Verhaltenssymptomen bei Demenz. 

Nervenarzt. 81:815-816, 818-822. 2010. IF: 0.681 

4. Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde ALW, Jessen F, 

Hoessler YC, Sanhai WR, Zetterberg H, Woodcock J, Blennow K. Biomarkers for treatment 

trials and diagnosis in Alzheimer’s disease: academic, industry and regulatory perspectives. 

Nat Rev Drug Discov. 9:560-574. 2010. IF: 29.008 


1. Bach JP, Spottke A, Jessen F, Dodel R. Rationale Behandlungsstrategien bei 

Alzheimerdemenz. Was bremst die Flucht der Gedanken? Neurologie und Psychiatrie. 3:42-48. 

2010. 

2. Jessen F. Alzheimer Demenz. Der niedergelassene Arzt. 9:37-42. 2010. 

3. Jessen F. Alzheimer-Krankheit: Neue Leitlinien und deren klinische Umsetzung. Current 

congress. 9:14. 2010. 

4. Jessen F. Bildgebende Verfahren in der Diagnostik von Demenzerkrankungen. 

Nervenheilkunde. 29:758-760. 2010. 

5. Jessen F, Maier W. Demenzerkrankungen. Pharma-Fokus ZNS. 9:24-28. 2010. 

6. Maier W, Jessen F. Update Demenzen. Der Neurologe & Psychiater DNP. 10:2-4. 2010. 

14


Buchbeiträge 

1. Jessen F. Psychiatrische Syndrome bei neurologischen Erkrankungen. In: Roter Faden 

Neurologie, Eds. Dodel R, Klockgether T. Wissenschaftliche Verlagsgesellschaft Stuttgart. 709- 

723. 2010. ISBN: 978-3-8047-2449-5 

2. S3-Leitlinie Demenzen 

Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN), 

Deutsche Gesellschaft für Neurologie (DGN). Diagnose- und Behandlungsleitlinie Demenz. 

Springer Verlag, Heidelberg. 2010. ISBN 978-3-642-13092-2 

2009 


1. Jessen F, Schuhmacher A, von Widdern O, Guttenthaler V, Hofels S, Suliman H, Scheef L, 

Block W, Urbach H, Maier W, Zobel. A. No association of the Val66Met polymorphism of the 

brain-derived neurotrophic factor with hippocampal volume in major depression. Psychiatr 

Genet. 19:99-101. 2009. IF: 2.581 

2. Jessen F, Gür O, Block W, Ende G, Frölich L, Hammen T, Wiltfang J, Kucinski T, Jahn H, 

Heun R, Maier W, Kölsch H, Kornhuber J, Träber F. A multicenter (1)H-MRS study of the 

medial temporal lobe in AD and MCI. Neurology. 72:1735-1740. 2009. IF: 8.312 

3. Popp J, Bacher M, Kölsch H, Noelker C, Deuster O, Dodel R, Jessen F. Macrophage migration 

inhibitory factor in mild cognitive impairment and Alzheimer's disease. J Psychiatr Res. 43:749- 

753. 2009. IF: 4.664 

4. Block W, Träber F, von Widdern O, Metten M, Schild H, Maier W, Zobel A, Jessen F. Proton 

MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive 

disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol. 

12:415-422. 2009. IF: 4.578 

5. Popp J, Schaper K, Kölsch H, Cvetanovska G, Rommel F, Klingmüller D, Dodel R, Wüllner U, 

Jessen F. CSF cortisol in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 

30:498-500. 2009. IF: 6.189 

15



1. Zobel A, Schuhmacher A, Jessen F, Höfels S, von Widdern O, Metten M, Pfeiffer U, Hanses 

C, Becker T, Rietschel M, Scheef L, Block W, Schild HH, Maier W, Schab SG. DNA-sequence 

variants of the FKBP5 gene are associated with unipolar depression. Int J 

Neuropsychopharmacol. 13:649-660. 2009. IF: 4.578 

2. Ehreke L, Luppa M, Luck T, Wiese B, Weyerer S, Eifflaender-Gorfer S, Weeg D, Olbrich J, van 

den Bussche H, Bachmann C, Eisele M, Maier W, Jessen F, Wagner M, Fuchs A, Pentzek M, 

Angermeyer MC, König HH, Riedel-Heller SG; AgeCoDe group. Is the clock drawing test 

appropriate for screening for mild cognitive impairment?--Results of the German study on 

Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Dement Geriatr Cogn 

Disord. 28:365-372. 2009. IF: 2.141 

3. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, Singh Pahwa J, 

Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan A, Lovestone S, 

Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan 

K, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, 

Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier M, Jessen F, 

Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, 

Hampel H, Hül M, Rujescu D, Goate A, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo 

K, Bettens K, Sleegers K, Engelborghs S, De Deyn P, van Broeckhoven C, Livingston G, Bass 

NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, 

Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, 

Wichmann HE, Carrasquillo MM, Pankratz SV, Younkin SG, Holmans P, O’Donovan M, Owen 

MJ, Williams J. Genome-wide association study identifies variants at CLU and PICALM 

associated with Alzheimer's disease, and shows evidence for additional susceptibility genes. 

Nat Genet. 41:1088-1093. Erratum: 41:1156. 2009. IF: 35.532 

4. Luck T, Riedel-Heller SG, Wiese B, Stein J, Weyerer S, Werle J, Kaduszkiewicz H, Wagner M, 

Mösch E, Zimmermann T, Maier W, Bickel H, van den Bussche H, Jessen F, Fuchs A, 

Pentzek M; für die AgeCoDe Study Group. CERAD-NP-Testbatterie: Alters-, geschlechts- und 

bildungsspezifische Normen ausgewählter Subtests : Ergebnisse der German Study on 

Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Z Gerontol Geriatr. 

42:372-384. 2009. IF: 0.613 

5. Klafki HW, Lewczuk P, Kamrowski-Kruck H, Maler JM, Müller K, Peters O, Heuser I, Jessen F, 

Popp J, Frölich L, Wolf S, Prinz B, Luckhaus C, Schröder J, Pantel J, Gertz HJ, Kölsch H, 

Müller BW, Esselmann H, Bibl M, Kornhuber J, Wiltfang J. Measurement of ERK 1/2 in CSF 

16


from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated 

Form. J Alzheimers Dis. 18:613-622. 2009. IF: 3.745 

6. Kölsch H, Wagner M, Bilkei-Gorzó A, Toliat MR, Pentzek M, Fuchs A, Kaduszkiewicz H, van 

den Bussche H, Riedel-Heller SG, Angermeyer MC, Weyerer S, Werle J, Bickel H, Mösch E, 

Wiese B, Daerr M, Jessen F, Maier W, Dichgans M. Gene polymorphisms in prodynorphin 

(PDYN) are associated with episodic memory in the elderly. J Neural Transm. 116:897-903. 

2009. IF: 2.730 

7. Alexopoulos P, Günther F, Popp J, Jessen F, Peters O, Wolf S, Kneib T, Kurz A, Richter- 

Schmidinger T, Lewczuk P, Bleich S, Wiltfang J, Kornhuber J. Plasma homocysteine and 

cerebrospinal fluid neurodegeneration biomarkers in mild cognitive impairment and dementia. J 

Am Geriatr Soc. 57:737-739. 2009. IF: 3.737 

8. Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Friedrichs S, Maier TA, 

Heun R. RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism. 

J Cell Mol Med. 13:589-598. 2009. IF: 4.125 

9. Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J, Frölich L, 

Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hüll M, Kurz A, Rüther E, 

Henn FA, Maier W. Association of SORL1 gene variants with Alzheimer's disease. Brain Res. 

1264:1-6. 2009. IF: 2.728 

10. Kornhuber J, Schmidtke K, Frolich L, Perneczky R, Wolf S, Hampel H, Jessen F, Heuser I, 

Peters O, Weih M, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O, 

Seuchter SA, Rüther E, Henn F, Maier W, Wiltfang J. Early and differential diagnosis of 

dementia and mild cognitive impairment: design and cohort baseline characteristics of the 

German Dementia Competence Network. Dement Geriatr Cogn Disord. 27:404-417. 2009. IF: 

2.141 

11. Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Schmitz S, Maier W, Heun 

R. CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. Eur 

Psychiatry. 24:183-190. 2009. IF: 2.766 

12. Qureischie H, Heun R, Popp J, Jessen F, Maier W, Schmitz S, Hentschel F, Kelemen P, 

Kölsch H. Association of CETP polymorphisms with the risk of vascular dementia and white 

matter lesions. J Neural Transm. 116:467-472. 2009. IF: 2.730 

13. Hong GS, Heun R, Jessen F, Popp J, Hentschel F, Kelemen P, Schulz A, Maier W, Kölsch H. 

Gene variations in GSTM3 are a risk factor for Alzheimer's disease. Neurobiol Aging. 30:691- 

696. 2009. IF: 6.189 

17



1. Weyerer S, Schäufele M, Eifflaender-Gorfer S, Köhler L, Maier W, Haller F, Cvetanovska- 

Pllashiniku G, Pentzek M, Fuchs A, van den Bussche H, Zimmermann T, Eisele M, Bickel H, 

Mösch E, Wiese B, Angermeyer MC, Riedel-Heller SG; German AgeCoDe Study group. 

Further members of the German AgeCoDe Study group. At-risk alcohol drinking in primary 

care patients aged 75 years and older. Int J Geriatr Psychiatry. 24:1376-1385. 2009. IF: 2.419 

2. Pentzek M, Fuchs A, Wiese B, Cvetanovska-Pllashniku G, Haller F, Maier W, Riedel-Heller 

SG, Angermeyer MC, Bickel H, Mösch E, Weyerer S, Werle J, van den Bussche H, Eisele M, 

Kaduszkiewicz H; AgeCoDe study group. General practitioners' judgment of their elderly 

patients' cognitive status. J Gen Intern Med. 24:1314-1317. 2009. IF: 2.830 

Fallberichte 

1. Bach JP, Oertel WH, Dodel R, Jessen F. Treatment of hypersexuality in Parkinson's disease 

with carbamazepine – a case report. Mov Disord. 24:1241-1242. 2009. IF: 4.505 


1. Jessen F. Bildgebende Verfahren in der Diagnostik der Alzheimer Demenz. Journal für 

Neurologie, Neurochirurgie und Psychiatrie. 3:70-73. 2009. 

2. Jessen F. Diagnostik von Demenzerkrankungen. Heilberufe.61:4. 2009. 

3. Jessen F. Diagnostische Schärfe des Mini-Mental-Status Tests - Wann ist der Einsatz in der 

Hausarztpraxis sinnvoll? Info Neurologie & Psychiatrie. 6:20-21. 2009. 

4. Jessen F. Prävention und Frühbehandlung von Demenzen. Neuro Aktuell. 6:32-35. 2009. 

5. Jessen F, Maier W, Spottke A, Deuschl G. S3-Leitlinie Demenzen: Eine integrative Leistung 

zwischen Neurologie und Psychiatrie/Psychotherapie. MedReport. 44:15. 2009. 

Buchbeiträge 

18


1. Jessen F, Hampel H. MRI as a surrogate marker in clinical trials in Alzheimer's Disease. In: 

Imaging the aging brain, EDS. Jagust W, D'Esposito M. Oxford University Press. 305-318. 

2009. ISBN: 978-0-19-532887-5 

2. Jessen F. Liquordiagnostik. In: Diagnostik und Therapie von Demenzerkrankungen, Eds. 

Mahlberg R, Gutzmann H. Deutscher Ärzteverlag. 153-156. 2009. ISBN: 978-3-7691-0563-6 

3. Jessen F. Genetik. In: Diagnostik und Therapie von Demenzerkrankungen, Eds. Mahlberg R, 

Gutzmann H. Deutscher Ärzteverlag. 157-160. 2009. ISBN: 978-3-7691-0563-6 

2008 


1. Tepest R, Wang L, Csernansky JG, Neubert P, Heun R, Scheef L, Jessen F. Hippocampal 

surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's 

dementia. Dement Geriatr Cogn Disord. 26:323-329. 2008. IF: 2.141 

2. Schaper K, Kolsch H, Popp J, Wagner M, Jessen F. KIBRA gene variants are associated with 

episodic memory in healthy elderly. Neurobiol Aging. 29:1123-1125. 2008. IF: 6.189 


1. Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, 

Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach 

TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, 

Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos 

A, Stephan DA, Huentelman MJ. Evidence for an association between KIBRA and late-onset 

Alzheimer's disease. Neurobiol Aging. 31:901-909. 2008. IF: 6.189 

2. Qureischie H, Heun R, Lütjohann D, Popp J, Jessen F, Ledschbor-Frahnert C, Thiele H, Maier 

W, Hentschel F, Kelemen P, Kölsch H. CETP polymorphisms influence cholesterol metabolism 

but not Alzheimer's disease risk. Brain Res. 1232:1-6. 2008. IF: 2.728 

3. Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J, Frölich L, Heuser I, 

Peters O, Schulz JB, Schwab SG, Maier W. Influence of SORL1 gene variants: Association 

with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett. 440:68-71. 

2008. IF: 2.105 

19


4. Kircher T, Weis S, Leube D, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Krach S. 

Anterior hippocampus orchestrates successful encoding and retrieval of non-relational 

memory. An event-related fMRI study. Eur Arch Psychiatry Clin Neurosci. 258:363-372. 2008. 

IF: 3.494 

5. Leube DT, Weiss S, Freymann K, Erb M, Jessen F, Heun R, Grodd W, Kircher TT. Neuronal 

correlates of verbal episodic memory in patients with MCI and Alzheimer’s Disease – a VBM 

study. Int J Geriatr Psychiatry. 23:1114-1118. 2008. IF: 2.419 

6. Hurlemann R, Jessen F, Wagner M, Ruhrmann S, Brockhaus A, Picker H, Scheef L, Block W, 

Schild HH, Moller-Hartmann W, Krug B, Falkai P, Klosterkotter J, Maier W. Interrelated 

neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental 

state. Psychol Med. 38:843-851. 2008. IF: 6.159 

7. Weyerer S, Eifflaender-Gorfer S, Köhler L, Jessen F, Maier W, Fuchs A, Pentzek M, 

Kaduszkiewicz H, Bachmann C, Angermeyer MC, Luppa M, Wiese B, Mösch E, Bickel H. 

Prevalence and risk factors for depression in non-demented primary care attenders aged 75 

years and older. J Affect Disord. 111:153-163. 2008. IF: 3.517 

8. Zobel A, Jessen F, von Widdern O, Schuhmacher A, Höfels S, Metten M, Rietschel M, Scheef 

L, Block W, Becker T, H. Schild HH, Maier W, Schwab SG. Unipolar Depression and 

Hippocampal Volume: Impact of DNA-sequence variants of the Glucocorticoid Receptor Gene. 

Am J Med Genet B Neuropsychiatr Genet. 147B:836-843. 2008. IF: 3.705 

9. Lewczuk P, Kornhuber J, Vanderstichele H, Vanmechelen E, Esselmann H, Bibl M, Wolf S, 

Otto M, Reulbach U, Kölsch H, Jessen F, Schröder J, Schönknecht P, Hampel H, Peters O, 

Weimer E, Perneczky R, Jahn H, Luckhaus C, Lamla U, Supprian T, Maler JM, Wiltfang J. 

Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias 

and MCI: A multicenter study. Neurobiol Aging. 29:812-818. 2008. IF: 6.189 

10. Wüllner U, Gündisch D, Herzog H, Minnerop M, Joe A, Warnecke M, Jessen F, Schütz C, 

Reinhardt M, Eschner W, Klockgether T, Schmaljohann J. Smoking upregulates alpha4beta2* 

nicotinic acetylcholine receptors in the human brain. Neurosci Lett. 430:34-37. 2008. IF: 2.105 


1. Jessen F. Neue Perspektiven der Bildgebung in der Diagnostik bei Demenzen. Nervenarzt. 79 

Suppl 3:129-136. 2008. IF: 0.681 

20



1. Jessen F. Vier Fragen zu Morbus Alzheimer. Medical Tribune. 43:13. 2008. 

2. Maier W, Jessen F. Forschungsansätze in der Demenz. Neue Therapien sind absehbar. 

Neurotransmitter. 19,Suppl. 2:18-23. 2008. 

2007 


1. Jessen F, Wiese B, Cvetanovska G, Fuchs A, Kaduszkiewicz H, Kölsch H, Luck T, Mösch E, 

Pentzek M, Riedel-Heller SG, Werle J, Weyerer S, Zimmermann T, Maier W, Bickel H. Patterns 

of subjective memory impairment in the elderly: association with memory performance. Psychol 

Med. 37:1753-1762. 2007. IF: 6.159 

2. Popp J., Michael R. Freymann K, Jessen F. Häufigkeit und Risikofaktoren des 

postpunktionellen Syndroms bei ambulanter Durchführung einer diagnostischen 

Lumbalpunktion in der Gedächtnissprechstunde. Nervenarzt. 78:547-551. 2007. IF: 0.681 


1. Luck T, Riedel-Heller SG, Kaduszkiewicz H, Bickel H, Jessen F, Pentzek M, Wiese B, Koelsch 

H, van den Bussche H, Abholz HH, Moesch E, Gorfer S, Angermeyer MC, Maier W, Weyerer 

S; AgeCoDe group. Mild cognitive impairment in general practice: age-specific prevalence and 

correlate results from the German study on ageing, cognition and dementia in primary care 

patients (AgeCoDe). Dement Geriatr Cogn Disord. 24:307-316. 2007. IF: 2.141 

2. Kircher TT, Weis S, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Leube DT. 

Hippocampal activation in patients with mild cognitive impairment is necessary for successful 

memory encoding. J Neurol Neurosurg Psychiatry. 78:812-818. 2007. IF: 4.764 

3. Wiltfang J, Esselmann H, Bibl M, Hüll M, Hampel H, Kessler H, Frölich L, Schröder J, Peters O, 

Jessen F, Luckhaus C, Perneczky R, Jahn H, Fiszer M, Maler JM, Zimmermann R, 

Bruckmoser R, Kornhuber J, Lewczuk P. Amyloid beta peptide ratio 42/40 but not A beta 42 

21


correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J Neurochem. 

101:1053-1059. 2007. IF: 4.061 

4. Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, 

Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, 

Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML, 

Stephan DA, Craig DW. Identification of the genetic basis for complex disorders by use of 

pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum 

Genet. 80:126-139. 2007. IF: 10.603 

Fallberichte 

1. Popp J, Thal D, Lewczuk P, Wiltfang J, Jessen F. Histologically confirmed amyloid deposition 

and low CSF Aß42 in a cognitively normal subject. J Neurol. 254:970-971. 2007. IF: 3.473 


1. Jessen F, Maier W. Ein Beitrag zur aktuellen Antidementiva-Diskussion in Deutschland. 

Nervenarzt. 78:491-497. 2007. IF: 0.681 

Buchbeiträge 

1. Schmidtke K, Frölich L, Hüll M, Jessen F. Rahmenkonzept Demenz. In: Versorgungskonzepte 

in der Neurologie, Eds: Meier U, Diener HC. Georg Thieme Verlag. 89-96. 2007. 978-3-13- 

143671-9 

2006 


1. Jessen F, Träber F, Freymann K, Maier W, Schild HH, Block W. Treatment monitoring and 

response prediction with proton MR spectroscopy in AD. Neurology. 67:528-530. 2006. IF: 

8.312 

22


2. Jessen F, Scherk H, Traber F, Theyson S, Berning J, Tepest R, Falkai P, Schild HH, Maier W, 

Wagner M, Block W. Proton magnetic resonance spectroscopy in subjects at risk for 

schizophrenia. Schizophr Res. 87:81-88. 2006. IF: 4.748 

3. Traber F, Block W, Freymann N, Gur O, Kucinski T, Hammen T, Ende G, Pilatus U, Hampel H, 

Schild HH, Heun R, Jessen F. A multicenter reproducibility study of single-voxel 1H-MRS of 

the medial temporal lobe. Eur Radiol. 16:1096-1103. 2006. IF: 3.222 

4. Jessen F, Feyen L, Freymann K, Tepest R, Maier W, Heun R, Schild HH, Scheef L. Volume 

reduction of the entorhinal cortex in subjective memory impairment. Neurobiol Aging. 27:1751- 

1759. 2006. IF: 6.189 


1. Holzapfel J, Heun R, Lutjohann D, Jessen F, Maier W, Kolsch H. PPARD haplotype influences 

cholesterol metabolism but is no risk factor of Alzheimer's disease. Neurosci Lett. 408:57-61. 

2006. IF: 2.105 

2. Heun R, Freymann K, Erb M, Leube DT, Jessen F, Kircher TT, Grodd W. Successful verbal 

retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate 

activation. Dement Geriatr Cogn Disord. 22:165-172. 2006. IF: 2.141 

3. Teipel SJ, Ewers M, Dietrich O, Schoenberg SO, Jessen F, Heun R, Freymann N, Moller HJ, 

Hampel H. Multizentrische Reliabilität MRT-gestützter Volumetrie des Gehirns. Nervenarzt. 

77:1086-1095. 2006. IF: 0.681 

4. Ewers M, Teipel SJ, Dietrich O, Schonberg SO, Jessen F, Heun R, Scheltens P, Pol LV, 

Freymann NR, Moeller HJ, Hampel H. Multicenter assessment of reliability of cranial MRI. 

Neurobiol Aging. 27:1051-1059. 2006. IF: 6.189 

5. Kölsch H, Lutjohann D, Jessen F, Von Bergmann K, Schmitz S, Urbach H, Maier W, Heun R. 

Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk 

factor of Alzheimer's disease. Int J Mol Med. 17:791-794. 2006. IF: 1.573 

6. Quednow BB, Jessen F, Kuhn KU, Maier W, Daum I, Wagner M. Memory deficits in abstinent 

MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction. J 

Psychopharmacol. 20:373-384. 2006. IF: 3.036 

23


7. Heun R, Freymann K, Erb M, Leube DT, Jessen F, Kircher TT, Grodd W. Mild cognitive 

impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly. 

Neurobiol Aging. 28:404-413. 2006. IF: 6.189 


1. Jessen F. Sind subjektive Gedächtnisstörungen ein Prodromalsyndrom der Demenz? 


2. Jessen F, Maier W. Prognose von kognitiven Störungen im Alter. MedReport. 27:8. 2007. 

3. Maier W, Jessen F. Was gibt es Neues in der Diagnostik von Demenzen? Surrogate-Marker 

rücken in den Vordergrund. Notfall und Hausarztmedizin. 12:566-570. 2007. 


1. Jessen F. Demenzen. Der niedergelassene Arzt. 55:11-16. 2006. 

2. Jessen F. Früherkennung von Demenzen - Bildgebung auch schon im Stadium der 

subjektiven Gedächtnisstörungen auffällig. Neuro-Psychiatrische Nachrichten. 10:14. 2006. 

3. Jessen F. Neue Befunde zur MR-Spektroskopie. Neuro-Psychiatrische Nachrichten. 10:13. 

2006. 

4. Jessen F, Frölich L, Schmidtke K, Hüll M. Die Herausforderung wird nur im Netzwerk zu 

bewältigen sein. Neurologie & Psychiatrie. Sonderheft 1:30-32. 2006. 

2005 


1. Jessen F, Traeber F, Freymann N, Maier W, Schild HH, Heun R, Block W. A comparative 

study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's 

disease. Dement Geriatr Cogn Disord. 20:178-183. 2005. IF: 2.141 

2. Heun R, Kolsch H, Jessen F. Risk factors and early signs of Alzheimer's disease in a family 

study sample Risk of AD. Eur Arch Psychiatry Clin Neurosci. 256:28-36. 2005. IF: 3.494 

24



1. Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IG, Jessen F, Schulz A, Maier W, 

Kolsch H. APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Ann Neurol. 

58:436-441. 2005. IF: 11.089 

2. Schmaljohann J, Gundisch D, Minnerop M, Joe A, Bucerius J, Dittmar C, Jessen F, Guhlke S, 

Wullner U. A simple and fast method for the preparation of n.c.a. 2-[(18)F]F-A85380 for human 

use. Appl Radiat Isot. 63:433-435. 2005. IF: 1.172 

3. Kölsch H, Lutjohann D, Jessen F, Urbach H, von Bergmann K, Maier W, Heun R. 

Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of 

Alzheimer's disease. J Neural Transm. 113:231-238. 2005. IF: 2.730 

4. Heun R, Kolsch H, Jessen F. Risk factors and early signs of Alzheimer's disease in a family 

study sample Risk of AD. Eur Arch Psychiatry Clin Neurosci. 256:28-36. 2005. IF: 3.494 

5. Kolsch H, Jessen F, Freymann N, Kreis M, Hentschel F, Maier W, Heun R. ACE I/D 

polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. Neurosci 

Lett. 377:37-39. 2005. IF: 2.105 

Fallberichte 

1. Freymann N, Michael R, Dodel R, Jessen F. Successful treatment of sexual disinhibition in 

dementia with carbamazepine – a case report. Pharmacopsychiatry. 38:144-145. 2005. IF: 

2.071 


1. Jessen F, Ewers M, Träber F, Teipel S, Gür O, Block W, Hampel H. Früh- und 

Differenzialdiagnose von Demenzen - MR-Volumetrie und Protonen-MR-Spektroskopie. 


2004 

25



1. Heun R, Ptok U, Kolsch H, Maier W, Jessen F. Contribution of apolipoprotein E and cathepsin 

D genotypes to the familial aggregation of Alzheimer's disease. Dement Geriatr Cogn Disord. 

18:151-158. 2004. IF: 2.141 


1. Kolsch H, Linnebank M, Lutjohann D, Jessen F, Wullner U, Harbrecht U, Thelen KM, Kreis M, 

Hentschel F, Schulz A, von Bergmann K, Maier W, Heun R. Polymorphisms in glutathione Stransferase 

omega-1 and AD, vascular dementia, and stroke. Neurology. 63:2255-2260. 2004. 

IF: 8.312 

2. Heun R, Freymann N, Granath DO, Stracke CP, Jessen F, Barkow K, Reul J. Differences of 

cerebral activation between superior and inferior learners during motor sequence encoding and 

retrieval. Psychiatry Res. 132:19-32. 2004. IF: 2.964 

3. Heun R, Ptok U, Kolsch H, Maier W, Jessen F. Contribution of apolipoprotein E and cathepsin 

D genotypes to the familial aggregation of Alzheimer's disease. Dement Geriatr Cogn Disord. 

18:151-158. 2004. IF: 2.141 

4. Heun R, Erb, N, Jessen F, Klose, U, Granath D, Grodd W. 2004. Response-Related fMRI of 

verdical and false recognition of words. Eur Psychiatry. 19:42-52. 2004. IF: 2.766 

2003 


1. Jessen F, Scheef L, Germeshausen L, Tawo Y, Kockler M, Kuhn KU, Maier W, Schild HH, 

Heun R. Reduced hippocampal activation during encoding and recognition of words in 

schizophrenia patients. Am J Psychiatry. 160:1305-1312. 2003. IF: 12.539 


1. Bagli M, Papassotiropoulos A, Hampel H, Becker K, Jessen F, Burger K, Ptok U, Rao ML, 

Moller HJ, Maier W, Heun R. Polymorphisms of the gene encoding the inflammatory cytokine 

interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in 

26


Alzheimer's disease Results of a pilot study. Eur Arch Psychiatry Clin Neurosci. 253:44-48. 

2003. IF: 3.494 

2. Hein S, Bonsignore M, Barkow K, Jessen F, Ptok U, Heun R. Lifetime depressive and somatic 

symptoms as preclinical markers of late-onset depression. Eur Arch Psychiatry Clin Neurosci. 

253:16-21. 2003. IF: 3.494 

3. Ehl C, Kolsch H, Ptok U, Jessen F, Schmitz S, Frahnert C, Schlosser R, Rao ML, Maier W, 

Heun R. Association of an interleukin-1beta gene polymorphism at position -511 with 

Alzheimer's disease. Int J Mol Med. 11:235-238. 2003. IF: 1.573 

2002 


1. Jessen F, Manka C, Scheef L, Granath DO, Schild HH, Heun R. Novelty detection and 

repetition suppression in a passive picture viewing task: a possible approach for the evaluation 

of neuropsychiatric disorders. Hum Brain Mapp. 17:230-236. 2002. IF: 5.880 


1. Kolsch H, Lutjohann D, Ludwig M, Schulte A, Ptok U, Jessen F, von Bergmann K, Rao ML, 

Maier W, Heun R. Polymorphism in the cholesterol 24S-hydroxylase gene is associated with 

Alzheimer's disease. Mol Psychiatry. 7:899-902. 2002. IF: 13.668 

2. Papassotiropoulos A, Lewis HD, Bagli M, Jessen F, Ptok U, Schulte A, Shearman MS, Heun 

R. Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are 

related to the exon 2 polymorphism of the cathepsin D gene. Neuroreport. 13:1291-1294. 2002. 

IF: 1.656 

3. Block W, Jessen F, Traber F, Flacke S, Manka C, Lamerichs R, Keller E, Heun R, Schild H. 

Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic 

resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol. 59:828-834. 

2002. IF: 7.584 


27


1. Block W, Traber F, Flacke S, Jessen F, Pohl C, Schild H. In-vivo proton MR-spectroscopy of 

the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for 

neurodegeneration. Amino Acids. 23:317-323. 2002. IF: 3.248 

2001 


1. Jessen F, Flacke S, Granath DO, Manka C, Scheef L, Papassotiropoulos A, Schild HH, Heun 

R. Encoding and retrieval related cerebral activation in continuous verbal recognition. Brain 

Res Cogn Brain Res. 12:199-206. 2001. IF: 2.884 

2. Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, Schild HH, Heun R. Decrease 

of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology. 

57:930-932. 2001. IF: 8.312 

3. Jessen F, Fries T, Kucharski C, Nishimura T, Hoenig K, Maier W, Falkai P, Heun R. Amplitude 

reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia. 

Neurosci Lett. 309:185-188. 2001. IF: 2.105 

4. Jessen F, Kucharski C, Fries T, Papassotiropoulos A, Hoenig K, Maier W, Heun R. Sensory 

gating deficit expressed by a disturbed suppression of the P50 event- related potential in 

patients with Alzheimer's disease. Am J Psychiatry. 158:1319- 1321. 2001. IF: 12.539 


1. Ptok U, Seeher C, Jessen F, Papassotiropoulos A, Heun R. Inter-rater reliability of family 

history information on psychiatric disorders in relatives. Eur Arch Psychiatry Clin Neurosci. 

251:279-283. 2001. IF: 3.494 

2. Bonsignore M, Barkow K, Jessen F, Heun R. Validity of the five-item WH Well-Being Index 

(WHO-5) in an elderly population. Eur Arch Psychiatry Clin Neurosci. 251 Suppl 2:II27-31. 

2001. IF: 3.494 

3. Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, Buschfort R, Ptok U, 

Bjorkhem I, von Bergmann K, Heun R. 24S-hydroxycholesterol in cerebrospinal fluid is 

elevated in early stages of dementia. J Psychiatr Res. 36:27-32. 2001. IF: 4.664 

28


4. Heun R, Papassotiropoulos A, Jessen F, Maier W, Breitner JC. A family study of Alzheimer 

disease and early- and late-onset depression in elderly patients. Arch Gen Psychiatry. 58:190- 

196. 2001. IF: 12.016 

2000 


1. Jessen F, Block W, Traber F, Keller E, Flacke S, Papassotiropoulos A, Lamerichs R, Heun R, 

Schild HH. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the 

medial temporal lobe of patients with AD. Neurology. 55:684-688. 2000. IF: 8.312 

2. Jessen F, Heun R, Erb M, Granath DO, Klose U, Papassotiropoulos A, Grodd W. The 

concreteness effect: evidence for dual coding and context availability. Brain Lang. 74:103-112. 

2000. IF: 3.115 


1. Heun R, Jessen F, Klose U, Erb M, Granath D, Freymann N, Grodd W. Interindividual variation 

of cerebral activation during encoding and retrieval of words. Eur Psychiatry. 15:470-479. 2000. 

IF: 2.766 

2. Bagli M, Papassotiropoulos A, Jessen F, Schmitz S, Rao ML, Maier W, Heun R. Identical 

distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer 

disease and controls in a German population. Am J Med Genet. 96:775-777. 2000. IF: 2.479 

3. Heun R, Jessen F, Klose U, Erb M, Granath DO, Grodd W. Response-related fMRI analysis 

during encoding and retrieval revealed differences in cerebral activation by retrieval success. 

Psychiatry Res. 99:137-150. 2000. IF: 2.964 

4. Papassotiropoulos A, Bagli M, Becker K, Jessen F, Maier W, Rao ML, Ludwig M, Heun R. No 

association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's 

disease. Int J Mol Med. 6:587-589. 2000. IF: 1.573 

5. Majores M, Bagli M, Papassotiropoulos A, Schwab SG, Jessen F, Rao ML, Maier W, Heun R. 

Allelic association between the D10S1423 marker and Alzheimer's disease in a German 

population. Neurosci Lett. 289:224-226. 2000. IF: 2.105 

29


6. Papassotiropoulos A, Bagli M, Jessen F, Maier W, Forstl H, Kurz A, Heun R. Interaction of two 

genes possibly involved in the regulation of the amyloid precursor protein (APP) processing. 

Mol Psychiatry. 5:240-241. 2000. IF: 13.668 

7. Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, Rao ML, Maier W, Bjorkhem 

I, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal 

degeneration and potential state marker for Alzheimer's disease. Neuroreport. 11:1959-1962. 

2000. IF: 1.656 

8. Papassotiropoulos A, Bagli M, Jessen F, Frahnert C, Rao ML, Maier W, Heun R. Confirmation 

of the association between bleomycin hydrolase genotype and Alzheimer's disease. Mol 

Psychiatry. 5:213-215. 2000. IF: 13.668 

9. Burgmer M, Jessen F, Freyberger HJ. Polythetic diagnostic approach to the borderline 

personality disorder. the valency of the single criterion in the concept of professional therapists. 

Psychopathology. 33:119-124. 2000. IF: 1.816 

10. Bagli M, Papassotiropoulos A, Knapp M, Jessen F, Rao L, Maier W, Heun R. Association 

between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's 

disease risk in a German population. Neurosci Lett. 283:109-112. 2000. IF: 2.105 

11. Lutjohann D, Papassotiropoulos A, Bjorkhem I, Locatelli S, Bagli M, Oehring RD, Schlegel U, 

Jessen F, Rao ML, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol) 

is increased in Alzheimer and vascular demented patients. J Lipid Res. 41:195-198. 2000. IF: 

5.559 

12. Bagli M, Papassotiropoulos A, Jessen F, Rao ML, Maier W, Heun R. Gene-gene interaction 

between interleukin-6 and alpha2-macroglobulin influences the risk for Alzheimer's disease. 

Ann Neurol. 47:138-139. 2000. IF: 11.089 

1999 


1. Jessen F, Erb M, Klose U, Lotze M, Grodd W, Heun R. Activation of human language 

processing brain regions after the presentation of random letter strings demonstrated with 

event-related functional magnetic resonance imaging. Neurosci Lett. 270:13-16. 1999. IF: 

2.105 

30



1. Heun R, Klose U, Jessen F, Erb M, Papassotiropoulos A, Lotze M, Grodd W. Functional MRI 

of cerebral activation during encoding and retrieval of words. Hum Brain Mapp. 8:157-169. 

1999. IF: 5.880 

2. Schwab SG, Bagli M, Papassotiropoulos A, Jessen F, Maier W, Rao ML, Heun R. Alpha-1antichymotrypsin 

gene polymorphism and risk for sporadic Alzheimer's disease in a German 

population. Dement Geriatr Cogn Disord. 10:469-472. 1999. IF: 2.141 

3. Bagli M, Papassotiropoulos A, Schwab SG, Jessen F, Rao ML, Maier W, Heun R. No 

association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease 

in a German population. J Neurol Sci. 167:34-36. 1999. IF: 2.353 

4. Papassotiropoulos A, Bagli M, Jessen F, Rao ML, Schwab SG, Heun R. Early onset and lateonset 

depression are independent of the genetic polymorphism of apolipoprotein E. Dement 

Geriatr Cogn Disord. 10:258-261. 1999. IF: 2.141 

5. Papassotiropoulos A, Bagli M, Jessen F, Bayer TA, Maier W, Rao ML, Heun R. A genetic 

variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk 

for sporadic Alzheimer's disease. Ann Neurol. 45:666-668. 1999. IF: 11.089 

6. Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao ML, Ludwig M, Schwab SG, 

Heun R. Genetic polymorphism of cathepsin D is strongly associated with the risk for 

developing sporadic Alzheimer's disease. Neurosci Lett. 262:171-174. 1999. IF: 2.105 

1998 


1. Heun R, Papassotiropoulos A, Jessen F. The validity of psychometric instruments for detection 

of dementia in the elderly general population. Int J Geriatr Psychiatry. 13:368-380. 1998. IF: 

2.419 


1. Cobbers JM, Wolter M, Reifenberger J, Ring GU, Jessen F, An HX, Niederacher D, Schmidt 

EE, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis DN, Collins VP, Reifenberger G. 

31


Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL. Brain Pathol. 8:263- 

276. 1998. IF: 3.995 

32

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