B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
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Table 1-1. Adenosylcobalamin- and methylcobalamin-dependent reactions<br />
AdoCbl-dependent Isomerases MeCbl-dependent Methyltransferases<br />
Diol dehydratase:<br />
Methionine synthase:<br />
1,2-propanediol propionaldehyde + homocysteine CH3THF methionine +<br />
H20<br />
THF<br />
Glycerol dehydratase:<br />
glycerol β-hydroxypropionaldehyde<br />
+ H20<br />
Ethanolamine ammonia lyase:<br />
ethanolamine acetaldehyde + H20<br />
L-β-Lysine aminomutase:<br />
L-β-lysine <br />
L-erythro-3,5-diaminohexanoic acid<br />
D-α-Lysine aminomutase:<br />
D-α-lysine 2,5-diaminohexanoic acid<br />
D-Ornithine aminomutase:<br />
D-ornithine 2,4-diaminovaleric acid<br />
Methylmalonyl-CoA mutase:<br />
methylmalonyl-CoA succinyl-CoA<br />
Glutamate mutase:<br />
glutamate β-methylaspartate<br />
Isobutyryl-CoA mutase:<br />
isobutyryl-CoA butyryl-CoA<br />
Methyleneglutarate mutase:<br />
2-methylene glutarate <br />
3-methylitaconate<br />
Ribonucleotide reductase:<br />
NTP dNTP<br />
30<br />
Acetyl -CoA synthesis via Corrinoid/Fe<br />
protein:<br />
(a) CH3THF + corrinoid/FeS protein <br />
THF + CH3-corrinoid Fe/S protein<br />
(b) CH3-corrinoid Fe/S protein + carbon<br />
monoxide corrinoid Fe/S protein +<br />
acetyl-CoA<br />
Methyltetrahydromethanopterin:coenzyme<br />
M methyltransferase:<br />
CH3-H4MPT + coenzyme M <br />
H4MPT + CH3-coenzyme M<br />
Methanol:2-mercaptoethanesulfonic acid<br />
methyltransferase:<br />
CH3OH + coenzyme M <br />
CH3-coenzyme M + H20