B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
B12 METABOLISM IN HUMANS By NICOLE AURORA LEAL A ...
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Classes<br />
Eliminases<br />
Dehydratases<br />
OH<br />
Aminomutases<br />
OH<br />
1,2-propanediol<br />
H 2N COH<br />
NH 2<br />
Carbon skeleton mutases<br />
HOC<br />
Ribonucleotide reductases<br />
(P)PPO<br />
ethanolamine<br />
methylmalonyl-CoA<br />
H<br />
H<br />
OH<br />
O<br />
NDP, NTP<br />
Methyltransferases<br />
O<br />
Deaminases<br />
H 2N<br />
O<br />
H<br />
C<br />
CH 3<br />
NH 2<br />
H<br />
OH<br />
H<br />
OH<br />
O<br />
BASE<br />
31<br />
AdoCbl<br />
diol dehydratase<br />
ethanolamine ammonia lyase<br />
L-β-lysine 5,6 aminomutase<br />
O<br />
propionaldehyde<br />
H 3C<br />
CO SCoA<br />
AdoCbl<br />
methylmalonyl CoA-mutase<br />
HOC C<br />
cob(I)alamin<br />
Reactions<br />
AdoCbl<br />
AdoCbl<br />
CH 3Cbl<br />
O<br />
CH<br />
acetaldehyde<br />
β-lysine L-erythro 3,5 diaminohexanoic acid<br />
AdoCbl<br />
ribonucleotide reductase<br />
H 2<br />
C<br />
H 2<br />
+<br />
+<br />
succinyl-CoA<br />
HOC CH CH2 CH2 SH<br />
CH3THF THF<br />
HOC CH CH2 CH2 homocysteine<br />
methionine synthase<br />
methionine<br />
O<br />
H 3C<br />
O<br />
(P)PPO<br />
NH 2<br />
NH 2<br />
H<br />
H<br />
OH<br />
NH 2<br />
O<br />
dNDP, dNTP<br />
H 2O<br />
NH 3<br />
O<br />
COH<br />
CO SCoA<br />
H<br />
H<br />
H<br />
BASE<br />
S CH 3<br />
Figure 1-2. Different classes of cobalamin-dependent enzymes. The enzymes involved<br />
and the reactions they catalyze are highlighted.