PNH and Thrombosis - Aplastic Anemia & MDS International ...

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Initial hypercoagulability when coumadin is first started (!) • Opposite of desired effect • Can occur within a few hours • Usually this occurs before the INR reaches 1.8 to 2 • Can be prevented by giving injectable anticoagulant until the anti-coagulant effect starts to work (bridging)
Coumadin • Shouldn’t be taken during pregnancy • Bleeding risk • Effect can be reversed instantly by giving plasma transfusion • Effect can be reversed within a few hours by giving vitamin K • Reversal should be done if patient is bleeding or if the INR drifts up very high
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PNH and Thrombosis David J. Araten,
Page 3 and 4:
Tendency to clot inappropriately
Page 5 and 6:
Red cells moving in a blood vessel
Page 7:
Platelets Tissue factor fibrin
Page 14 and 15: Abnormal blood clotting • Starts
Page 16 and 17: Coagulation cascade Tissue factor
Page 18 and 19: We do not know which of these prote
Page 20 and 21: Anticoagulants* work to prevent the
Page 28 and 29: clot
Page 30 and 31: clot Clot in artery: Tissue does no
Page 32 and 33: clot Clot in a vein. Blood can not
Page 38 and 39: Blood Clots in PNH Patients (Hillme
Page 40 and 41: Sonogram of the Abdomen
Page 42 and 43: Watt BJ Haematol 2007 Dermal thromb
Page 44 and 45: Superior & Inferior Sinus Thrombosi
Page 46 and 47: Deep Vein thrombosis (DVT)
Page 48 and 49: Symptoms of Blood Clots DVT: leg sw
Page 50 and 51: Symptoms of Blood Clots Veins of Br
Page 52 and 53: Low threshold for radiologic tests
Page 54 and 55: marked worldwide differences • hi
Page 56 and 57: Risk of Thrombosis: Small PNH versu
Page 58 and 59: Management of Blood Clots An ounce
Page 60 and 61: Coumadin • No one dose of Coumadi
Page 62 and 63: Coumadin Doses Typically require ad
Page 66 and 67: Why take Coumadin at all? • Tried
Page 68 and 69: In 3 years, all of these drugs may
Page 70 and 71: Additional Risk Factors for Blood C
Page 72 and 73: Reversal of blood clots Clot bustin
Page 74 and 75: Sonogram : Portal Vein Before TPA A
Page 76 and 77: Prevention of thrombosis in PNH •
Page 78 and 79: Fewer Thrombotic Events With SOLIRI
Page 80 and 81: Recommendations regarding Eculizuma
Page 82 and 83: Recent Improvement in Survival of P
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PNH and Thrombosis - Aplastic Anemia & MDS International ...

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