PNH and Thrombosis - Aplastic Anemia & MDS International ...

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Reversal of blood clots Clot busting drugs Fibrinolysis Thrombolysis Tissue plasminogen activator TPA Activates the patient’s own system for removing clots Much more effective when given early after the start of a clot These drugs are also given for heart attacks <strong>and</strong> strokes Different dosing for venous thrombosis in <strong>PNH</strong> patients
Who should be considered for thrombolysis • Anyone with a recent blood clot in the brain or abdomen • Any serious pulmonary embolus • Any life threatening clot
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PNH and Thrombosis David J. Araten,
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Tendency to clot inappropriately
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Red cells moving in a blood vessel
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Platelets Tissue factor fibrin
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Abnormal blood clotting • Starts
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Coagulation cascade Tissue factor
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We do not know which of these prote
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Anticoagulants* work to prevent the
Page 28 and 29: clot
Page 30 and 31: clot Clot in artery: Tissue does no
Page 32 and 33: clot Clot in a vein. Blood can not
Page 38 and 39: Blood Clots in PNH Patients (Hillme
Page 40 and 41: Sonogram of the Abdomen
Page 42 and 43: Watt BJ Haematol 2007 Dermal thromb
Page 44 and 45: Superior & Inferior Sinus Thrombosi
Page 46 and 47: Deep Vein thrombosis (DVT)
Page 48 and 49: Symptoms of Blood Clots DVT: leg sw
Page 50 and 51: Symptoms of Blood Clots Veins of Br
Page 52 and 53: Low threshold for radiologic tests
Page 54 and 55: marked worldwide differences • hi
Page 56 and 57: Risk of Thrombosis: Small PNH versu
Page 58 and 59: Management of Blood Clots An ounce
Page 60 and 61: Coumadin • No one dose of Coumadi
Page 62 and 63: Coumadin Doses Typically require ad
Page 64 and 65: Initial hypercoagulability when cou
Page 66 and 67: Why take Coumadin at all? • Tried
Page 68 and 69: In 3 years, all of these drugs may
Page 70 and 71: Additional Risk Factors for Blood C
Page 74 and 75: Sonogram : Portal Vein Before TPA A
Page 76 and 77: Prevention of thrombosis in PNH •
Page 78 and 79: Fewer Thrombotic Events With SOLIRI
Page 80 and 81: Recommendations regarding Eculizuma
Page 82 and 83: Recent Improvement in Survival of P
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PNH and Thrombosis - Aplastic Anemia & MDS International ...

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