PNH and Thrombosis - Aplastic Anemia & MDS International ...

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Additional Risk Factors for Blood Clotting • Protein C deficiency • Protein S deficiency • Antithrombin III deficiency • Factor V Leyden • Prothrombin gene mutation • Pregnancy Antiphospholipid antibody (lupus anticoagulant, anti beta 2 glycoprotein 1 antibody, anti cardiolipin antibody test) Family members who have had blood clots
Who should NOT be on anticoagulation to prevent blood clots? High bleeding risk (e.g. blood in stool-- everyone should be tested first for this) Patient at high risk for trauma (professional ice hockey players) Low platelet count (for example, less than 50 for primary prevention, less than 20 for prevention of a second blood clot) Small PNH clone size (Aplastic Anemia with small PNH clone, “AA/PNH”) Patients on Eculizumab who have never had a blood clot (?)
Page 1 and 2:
PNH and Thrombosis David J. Araten,
Page 3 and 4:
Tendency to clot inappropriately
Page 5 and 6:
Red cells moving in a blood vessel
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Platelets Tissue factor fibrin
Page 14 and 15:
Abnormal blood clotting • Starts
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Coagulation cascade Tissue factor
Page 18 and 19:
We do not know which of these prote
Page 20 and 21: Anticoagulants* work to prevent the
Page 28 and 29: clot
Page 30 and 31: clot Clot in artery: Tissue does no
Page 32 and 33: clot Clot in a vein. Blood can not
Page 38 and 39: Blood Clots in PNH Patients (Hillme
Page 40 and 41: Sonogram of the Abdomen
Page 42 and 43: Watt BJ Haematol 2007 Dermal thromb
Page 44 and 45: Superior & Inferior Sinus Thrombosi
Page 46 and 47: Deep Vein thrombosis (DVT)
Page 48 and 49: Symptoms of Blood Clots DVT: leg sw
Page 50 and 51: Symptoms of Blood Clots Veins of Br
Page 52 and 53: Low threshold for radiologic tests
Page 54 and 55: marked worldwide differences • hi
Page 56 and 57: Risk of Thrombosis: Small PNH versu
Page 58 and 59: Management of Blood Clots An ounce
Page 60 and 61: Coumadin • No one dose of Coumadi
Page 62 and 63: Coumadin Doses Typically require ad
Page 64 and 65: Initial hypercoagulability when cou
Page 66 and 67: Why take Coumadin at all? • Tried
Page 68 and 69: In 3 years, all of these drugs may
Page 72 and 73: Reversal of blood clots Clot bustin
Page 74 and 75: Sonogram : Portal Vein Before TPA A
Page 76 and 77: Prevention of thrombosis in PNH •
Page 78 and 79: Fewer Thrombotic Events With SOLIRI
Page 80 and 81: Recommendations regarding Eculizuma
Page 82 and 83: Recent Improvement in Survival of P
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PNH and Thrombosis - Aplastic Anemia & MDS International ...

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