Chapter 9 - Radioprotectors

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Classification of Radioprotector (indirect mode protection) Prophylaxis (Pre-exposure protection) Mitigation (during or shortly after exposure) Treatment Systematic Hypoxia Amifostine Nitroxides Superoxide dismutase Selenium Stem cell therapy Intervention in the angiotensin pathway Anti-inflammatory treatments Growth factor treatments
Mitigators (Radical Scavengers) Free radicals are responsible for large amount of damage caused by ionizing radiations – Mitotic cell death – Tissue hypoxia – Late effects Fibrosis Vascular damage, organ damage Radiation mitigators aim to scavenge free radicals to prevent expression of toxicity For a mitigator to protect cells from radical damage, migator need to be present at time of radiation and in a sufficient concentration to compete with radicals - Citrin et al. The Oncologist (2010)
Page 1 and 2: Radioprotectors Prepared by Du Le M
Page 3 and 4: Definitions - Radioprotectors - Dos
Page 5 and 6: Dose reduction factor (DRF) DRF is
Page 7 and 8: Discoveries (Cont.) Patt’s result
Page 9 and 10: Indirect action of Cysteine on Thym
Page 11 and 12: Indirect action of Cysteine on Thym
Page 13 and 14: Development of more effective compo
Page 15 and 16: Recall: Events following radiation
Page 17 and 18: Prophylaxis
Page 19 and 20: Systemic Hypoxia (cont.) Systemic r
Page 21: Honess’ experiments Example (cont
Page 25 and 26: Amifostine (cont.) Is a phosphoroth
Page 27 and 28: Superoxide dismutase (SOD) Superoxi
Page 29 and 30: Classification of Radioprotector (i
Page 31 and 32: Haematopoietic growth factors Produ
Page 33 and 34: Epidermal growth factor (EGF) signa
Page 35 and 36: Transforming growth factors β- sig
Page 37 and 38: Angiotensin converting enzyme (ACE)
Page 39 and 40: Anti-inflammatory treatments (cont.
Page 41 and 42: References http://www.ccfa.org/what

Chapter 9 - Radioprotectors

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