Chapter 9 - Radioprotectors
Chapter 9 - Radioprotectors
Chapter 9 - Radioprotectors
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Growth factor treatments<br />
Growth factor: (Goustin et al. Cancer Research 1986)<br />
– a complex family of polypeptide hormones<br />
– produced by the body to control growth, division and maturation of blood<br />
cells by the bone marrow.<br />
– Regulate the division and proliferation of cells and influence the growth<br />
rate of some cancers<br />
Exogenous growth factors<br />
– Activate or stimulate tissues specific endogenous signalling cascades.<br />
– Haematopoietic growth factor<br />
– Keratinocyte growth factor<br />
Growth factor signalling<br />
– has been shown to change after radiation exposure<br />
– Inhibition of upregulated signalling cascades may be applied either by<br />
antibodies against the growth factor or the respective receptors<br />
– Tumour necrosis factor-α signalling<br />
– Transforming growth factors β- signaling
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