Chapter 9 - Radioprotectors

Nitroxides
Are stable free radicals, have an unpaired electron and
consist of a six- member ring piperidine derivative
Radiation pros:
– Is among most promising agent for future use as radioprotector.
In labaroratory, nitroxides was used to protect cells when
exposed to oxidative stress such as H 2O 2
– Preclinical studies have shown
that the oxidized form of a
nitroxide is a radioprotector in
both in vitro and in vivo models.
Radiation cons:
– Although the hydroxylamine exhibits antioxidant activity, it might
protect tumor as well as normal tissue against ionizing radiation
- Citrin et al. The Oncologist (2010)