Molecular characterisation of odontoblast during primary, secondary ...

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REFERENCES: References Abdullah, D., T.R. Pitt Ford, et al. (2002). "An evaluation of accelerated Portland cement as a restorative material." Biomaterials 23(19): 4001-10. Abedi, H., M. Torabinejad, et al. (1996). "The use of Mineral Trioxide Aggregate cement (MTA) as a pulp capping material. (abstract)." J Endod 22: 199. About, I. and T. A. Mitsiadis (2001). "Molecular aspects of tooth pathogenesis and repair: in vivo and in vitro models." Adv Dent Res 15: 59-62. Aeinehchi, M., B. Eslami, et al. (2003). "Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report." Int Endod J 36(3): 225-31. Aioub, M., F. Lezot, et al. (2007). "Msx2 -/- transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis." Bone 41(5): 851-9. Al-Hiyasat, A. S., K. M. Barrieshi-Nusair, et al. (2006). "The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study." J Am Dent Assoc 137(12): 1699-705. Allard, B., H. Magloire, et al. (2006). "Voltage-gated sodium channels confer excitability to human odontoblasts: possible role in tooth pain transmission." J Biol Chem 281(39): 29002-10. Andreasen, F. M. and B. V. Pedersen (1985). "Prognosis of luxated permanent teeth-the development of pulp necrosis." Endod Dent Traumatol 1(6): 207-20. Andreasen, F. M., Y. Zhijie, et al. (1987). "Occurrence of pulp canal obliteration after luxation injuries in the permanent dentition." Endod Dent Traumatol 3(3): 103-15. Asgary, S., M. Parirokh, et al. (2006). "SEM evaluation of neodentinal bridging after direct pulp protection with mineral trioxide aggregate." Aust Endod J 32(1): 26-30. Azizi, S. A., D. Stokes, et al. (1998). "Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts." Proc Natl Acad Sci U S A 95(7): 3908-13. Baker, S. M., R. V. Sugars, et al. (2009). "TGF-beta/extracellular matrix interactions in dentin matrix: a role in regulating sequestration and protection of bioactivity." Calcif Tissue Int 85(1): 66-74. Balemans, W., M. Ebeling, et al. (2001). "Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)." Hum Mol Genet 10(5): 537-43. Banchs, F. and M. Trope (2004). "Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?" J Endod 30(4): 196-200. Banerjee, A., E. A. Kidd, et al. (2003). "In vitro validation of carious dentin removed using different excavation criteria." Am J Dent 16(4): 228-30. Barthel, C. R., B. Rosenkranz, et al. (2000). "Pulp capping of carious exposures: treatment outcome after 5 and 10 years: a retrospective study." J Endod 26(9): 525-8. Baume, L. J. (1980). "The biology of pulp and dentine. A historic, terminologictaxonomic, histologic-biochemical, embryonic and clinical survey." Monogr Oral Sci 8: 1-220. Baume, L. J. (1980). Definitions and Classifications of the Pulpodentinal Tissues. The Biology of Pulp and Dentine. H. M. Meyers. Philadelphia. 8: 60-62. Begue-Kirn, C., A. J. Smith, et al. (1994). "Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression 152
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ECOLE DOCTORALE : Génétique, Cell
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ACKNOWLEDGEMENTS I wish to express
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Abstract : This research aimed to i
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CONTENTS List of Figures ………
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4.5.2 MSX2 and pulp repair ........
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Figure 11 : Dentine bridge formatio
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minutes. (DMP = dentine matrix prot
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lipofectamin ® vector only (MDPC v
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List of Tables: Table 1: Primer det
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1.1 Towards a biological approach I
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Introduction odontoblast processes
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Introduction Secondary dentine: thi
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Introduction Understanding the dist
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Introduction terms of the communica
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Figure 5 : There is a differential
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Introduction Movement of the dentin
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1.2.3.3 Consequences of new technol
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Introduction an apical nucleus, whe
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Introduction creates a physical bar
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Introduction polarisation and the d
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Introduction variations in pressure
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Introduction also express neurogeni
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1.4.1 Reactionary dentinogenesis In
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Introduction responses, including a
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Introduction superficial cells move
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Introduction induce dentine bridge
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Introduction Because of its highly
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Introduction (Hayashi 1982). At 11
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Introduction To date, involvement o
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Introduction In deeper cavities, wh
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Introduction dental papilla cells.
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2 Materials and Methods Material an
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Material and methods containing; 12
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2.1.2.3 Microarray analysis Materia
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Material and methods 2.2 Part Two:
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Material and methods a Modulyo free
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Material and methods Figure 16: Pri
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Material and methods To date, sever
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Material and methods (pH=6.8) with
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Material and methods (P), and calci
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Material and methods (Sigma, la Ver
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Material and methods visualized by
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2.4.2.6 MSX2 over-expression in imm
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Material and methods channel. Data
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Results Amelogenin, IBSP, DCN, Alka
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Results data previously reported fo
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91 MAPK PATHWAY probe set GENE ID b
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Results Alkaline phosphatase and am
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Figure 24: Mouse upper incisor (A)
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Figure 25: Phosphorylated p38 prote
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3.3 MSX2 proteins and dentinogenesi
Page 103 and 104: Figure 29: First upper molar in +/+
Page 105 and 106: 3.3.1.3 At 21days post natal : Resu
Page 107 and 108: Results expression, obtained using
Page 109 and 110: Figure 37: Immunohistochemical anal
Page 111 and 112: 3.3.4 BrdU IHC Results BrdU was inj
Page 113 and 114: 3.3.6 Quantitative RT-PCR (Q-RT-PCR
Page 115 and 116: Results 3.4 Design and use of a new
Page 117 and 118: Results Figure 46: Histology at 2 w
Page 119 and 120: Results cells is also characteristi
Page 121 and 122: 4 Discussion Discussion 4.1 Regulat
Page 123 and 124: Discussion odontoblast secretory be
Page 125 and 126: Discussion 4.2 Molecular characteri
Page 127 and 128: Discussion al. 2004; Magloire, Coub
Page 129 and 130: Discussion differences. Bone cells
Page 131 and 132: Discussion we can conclude that the
Page 133 and 134: Discussion pathway is complex and i
Page 135 and 136: Discussion odontoblast physiologica
Page 137 and 138: Discussion dentinogenesis. By perfo
Page 139 and 140: Discussion cellular and molecular s
Page 141 and 142: Discussion Notably, our results are
Page 143 and 144: Discussion contribute to reparative
Page 145 and 146: Discussion other species (Abedi, To
Page 147 and 148: Discussion dentinogenesis, some cel
Page 149 and 150: Discussion morphology. It was not p
Page 151 and 152: 5 Conclusion Discussion Research on
Page 153: Discussion Figure 50: 14 months pos
Page 157 and 158: References Faraco, I. M., Jr. and R
Page 159 and 160: References Kidd, E. A., A. Banerjee
Page 161 and 162: References antigen-expressing cells
Page 163 and 164: References Smith, A. J. and H. Leso
Page 165 and 166: References Yamashiro, T., M. Tummer
Page 167 and 168: References Appendix 1: Full list of
Page 169 and 170: probe set GENE ID baseline mean (LS
Page 191 and 192: Appendix 3: Molecular characterizat
Page 193: Appendix 5: Evaluation of a new lab
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