- Page 1: THE UI\JIVERSITY OF ALBERTA ANTIFUN
- Page 4 and 5: Abstract A fungus observed to inhib
- Page 6 and 7: Acknowledgements 1would like to exp
- Page 8 and 9: LIST Of TABLES Table Page 1. Taxono
- Page 10 and 11: LIST OF SCHEMES Scheme Page 1. ln v
- Page 12: of the landscape. C. ulmi. causal a
- Page 15 and 16: Fig. 1. Photo of Arthrosporae fungu
- Page 17: 8 9 10 11 7 OH RI =O. Rl =
- Page 21: 18 OH anhydroarthrosporone 12 11. a
- Page 25 and 26: acetate 1pentane 1: 1L* A reddish c
- Page 28: H appears as a doublet (J = 14Hz) a
- Page 32 and 33: in 20 (0 2.56 (ddl. 2.40 (dl and 0
- Page 34 and 35: visualized on analytical tic using
- Page 37: The spectroscopie data led to the f
- Page 40 and 41: { H",o V B: --' 35 36 1clyO XV •
- Page 43: Bond formation between C-' (partial
- Page 50: Table 5: IH NMR Spectral Data for A
- Page 56 and 57: 50 28 = 20 OH 51 ......OH o KOHl Et
- Page 58 and 59: Table 7. lH NMR Spectral Data for A
- Page 60: which the C-3 methyl is in the a co
- Page 64 and 65: 58 DAc o o o 61.25 1 1 61.15 Table
- Page 66 and 67: The IH NMR spectrum of 60 shows a s
- Page 68 and 69: more complex reaction occurred. Inv
- Page 70 and 71: arthrosporone (20) was subjected to
- Page 72 and 73:
oil. Monoacetate 66 is the most pol
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Table 15. lH NMR Spectral Data for
- Page 77:
Reduction of arthrosporone al 50 pr
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Conclusive evidence that Î soarthr
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o A À max (calcd.) = 239 nm c B (e
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OH, 1696, 1616 cm-I). The lH NMR sp
- Page 90:
oxygen atom. This coupling pattern
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Table 19. Chemical Shift for H·" i
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as that of H-6a. H-6tl (0 2.79) and
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III. EXPERIMENTAL Distilled water u
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weeks. The shake culture (400 mU wa
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Table 1. POlarity of the Gradient E
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Purification of eis,anti,eis-2{3,3{
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1.60 (lH, t, 12 Hz, H-lla), 1.51 (l
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FTIR (CH,CI 2, cast): 3502 (strong)
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(C 4H 9 ,41.8). IH NMR (CDCI 3 ): 0
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15.0 Hz, H-9b), 1.06 (3H, s, H-13),
- Page 129 and 130:
HREIMS: ml z (fragment, intensity),
- Page 131 and 132:
(Skellysolve B / diethyl ether): m.
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CIMS (NHJ mlz calcd for M+ 18: 398;
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DMAP were added and the mixture was
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Table 3. Antibiotic Bioassay of Cru
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Table 5: Antifungal Bioassay of Cru
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Table 7: Antifungsl Bioassay of Kno
- Page 144 and 145:
. 24. a. b. Bennett, JW.; Ciegler,
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35. a. b. c. 37. a. b. 38. a. b. 39
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55. a. Poppleston, C.R. Cano J. Che
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APPENDIX 141
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4 3 2 FIgure 7. 400 MHz lH NMR spec
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Figure 13. 400 MHz IH NMR spectrum
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SESQUITERPENOïDES ANTIFONGIQUES D'
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Cette thèse a été soumise à la
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· Quant à ce qui concerne l'arthr
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\1 Culture du Champignon Arthrospor
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9 - 4-0-ACETYLARTHROSPOROL 16 Une s
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CONCLUSION Les études entreprises
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H 3 C H 3 C 1 R'=R"=H 5 R'=Ac R"=H