Brucella

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In B. abortus, an intact LPS core is required for: Resistance to the bactericidal action of polycationic peptides and normal serum. Multiplication in dendritic cells and inhibition of maturation. Inhibition of recognition by MD-2. As a consequence, SAID: Shield Anti-Immune Detection lpcC mutants may be promising vaccines
<strong>Brucella</strong>: a stealth pathogen • resistance to host cell bactericidal molecules/activities • intracellular survival and replication • ability to hide from and modulate the host immune response
Page 1: Brucella Pathogenesis Septses 09 20
Page 4 and 5: ISOLATION OF BRUCELLAE 19 th Centu
Page 13 and 14: HUMAN PATHOGENS
Page 15 and 16: HUMAN PATHOGENS B.melitensis B.abor
Page 22 and 23: B.melitensis GLOBAL STATUS
Page 24 and 25: B.melitensis GLOBAL STATUS B.melite
Page 26 and 27: B.melitensis GLOBAL STATUS B.melite
Page 28 and 29: Human brucellosis: symptoms & evolu
Page 30 and 31: Brucella Gram negative Cocobacilli
Page 32: Flagella Type III and IV SS Brucell
Page 37 and 38: From Intracellular Niches of Microb
Page 39 and 40: •Brucella mutants in components o
Page 41: In B. abortus, an intact LPS core i
Page 45 and 46: 5 min 1 h 4 h 8 h 12 h Biogenesis o
Page 47 and 48: Lack of ER fusion with virB mutant-
Page 49 and 50: Log CFU 8 7 6 5 4 3 2 Brucella repl
Page 51 and 52: Does Brucella affect maturation of
Page 53 and 54: 24h DCs with DALIS (%) 100 80 60 40
Page 55 and 56: Brucella interferes with the immune
Page 57 and 58: Btp1 contributes to blocking DC mat
Page 59 and 60: •Btp1 acts on the myd88/TLR2 path
Page 61 and 62: Cyclic glucan prevents Brucella fus
Page 63 and 64: Conclusions • Both macrophages an

Brucella

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