Brucella

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Brucella infection of dendritic cells New cell model for studying Brucella virulence: murine bone Salcedo et al. 2008 PLoS Pathog. marrow-derived dendritic cells
Log CFU 8 7 6 5 4 3 2 Brucella replicates in DCs wt B. abortus Salmonella virB - 1 0 20 40 60 Time post-infection (h) 30 h LPS wt-DSRed % DCs with intracellular bacteria 100 80 60 40 20 0 2 12 24 48 time post-infection (h) 1-5 5-10 >10
Page 1: Brucella Pathogenesis Septses 09 20
Page 4 and 5: ISOLATION OF BRUCELLAE 19 th Centu
Page 13 and 14: HUMAN PATHOGENS
Page 15 and 16: HUMAN PATHOGENS B.melitensis B.abor
Page 22 and 23: B.melitensis GLOBAL STATUS
Page 24 and 25: B.melitensis GLOBAL STATUS B.melite
Page 26 and 27: B.melitensis GLOBAL STATUS B.melite
Page 28 and 29: Human brucellosis: symptoms & evolu
Page 30 and 31: Brucella Gram negative Cocobacilli
Page 32: Flagella Type III and IV SS Brucell
Page 37 and 38: From Intracellular Niches of Microb
Page 39 and 40: •Brucella mutants in components o
Page 41 and 42: In B. abortus, an intact LPS core i
Page 43 and 44: Brucella: a stealth pathogen • re
Page 45 and 46: 5 min 1 h 4 h 8 h 12 h Biogenesis o
Page 47: Lack of ER fusion with virB mutant-
Page 51 and 52: Does Brucella affect maturation of
Page 53 and 54: 24h DCs with DALIS (%) 100 80 60 40
Page 55 and 56: Brucella interferes with the immune
Page 57 and 58: Btp1 contributes to blocking DC mat
Page 59 and 60: •Btp1 acts on the myd88/TLR2 path
Page 61 and 62: Cyclic glucan prevents Brucella fus
Page 63 and 64: Conclusions • Both macrophages an

Brucella

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