Brucella

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Brucella replicates within host cells CFU/well 10 8 10 7 10 6 10 5 10 4 0 10 20 30 40 50 time post infection (h) C57BL/6 mice bone marrow-derived macrophages Brucella abortus 2308-GFP Brucella-containing vacuole (BCV)
5 min 1 h 4 h 8 h 12 h Biogenesis of the BCV in macrophages Early BCV EEA + , Rab5 + , TfR + Intermediate BCV LAMP1 + , Rab7 — , M6P — (Pizarro Cerda, Many!!!) Replicative BCV LAMP1 — , Cathepsin D — Calreticulin + , Calnexin + , Se61ß + , PDI + Require Rab2, GAPDH (Fugier PloS Pathogen 2010) Sar1 (Celli, J Exp Med, 2003)
Page 1: Brucella Pathogenesis Septses 09 20
Page 4 and 5: ISOLATION OF BRUCELLAE 19 th Centu
Page 13 and 14: HUMAN PATHOGENS
Page 15 and 16: HUMAN PATHOGENS B.melitensis B.abor
Page 22 and 23: B.melitensis GLOBAL STATUS
Page 24 and 25: B.melitensis GLOBAL STATUS B.melite
Page 26 and 27: B.melitensis GLOBAL STATUS B.melite
Page 28 and 29: Human brucellosis: symptoms & evolu
Page 30 and 31: Brucella Gram negative Cocobacilli
Page 32: Flagella Type III and IV SS Brucell
Page 37 and 38: From Intracellular Niches of Microb
Page 39 and 40: •Brucella mutants in components o
Page 41 and 42: In B. abortus, an intact LPS core i
Page 43: Brucella: a stealth pathogen • re
Page 47 and 48: Lack of ER fusion with virB mutant-
Page 49 and 50: Log CFU 8 7 6 5 4 3 2 Brucella repl
Page 51 and 52: Does Brucella affect maturation of
Page 53 and 54: 24h DCs with DALIS (%) 100 80 60 40
Page 55 and 56: Brucella interferes with the immune
Page 57 and 58: Btp1 contributes to blocking DC mat
Page 59 and 60: •Btp1 acts on the myd88/TLR2 path
Page 61 and 62: Cyclic glucan prevents Brucella fus
Page 63 and 64: Conclusions • Both macrophages an

Brucella

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