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37°C<br />
Contact<br />
virF virB<br />
ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG<br />
IpaC<br />
IpgC<br />
IpaB<br />
IpgC<br />
virF virB<br />
MxiE<br />
OspD1<br />
TTSS<br />
ipaC ipaB ipgC mxi-spa mxiE ipaHs ospBCDEFG<br />
IpaC<br />
IpgC<br />
IpaB<br />
MxiE MxiE<br />
IpgC IpgCOspD1<br />
OspD1 IpgC<br />
IpaC IpaB<br />
MxiE<br />
OspD1<br />
IpaH<br />
IpaH<br />
Osp<br />
Osp<br />
?<br />
Regul<strong>at</strong>ory cascade controling<br />
transcription of ipaH & osp genes<br />
in response to two external signals:<br />
(1) temper<strong>at</strong>ure<br />
(2) TTSS activ<strong>at</strong>ion<br />
The mxiE regulon<br />
AraC-family transcription<br />
activ<strong>at</strong>or: MxiE<br />
Anti-activ<strong>at</strong>or: OspD1<br />
Coactiv<strong>at</strong>or: IpgC<br />
Anti-coactiv<strong>at</strong>ors: IpaB, IpaC<br />
Parsot C, Demers B, Mavris M,<br />
Penno C, Bongrand C et al.
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