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Model of assembly of the TTSS<br />
Outer membrane<br />
ring<br />
(secretin/pilotin)<br />
MxiD<br />
MxiM<br />
Sani et al., 2006<br />
Veenendaal et al., 2007<br />
IpaD<br />
+ IpaB<br />
Sec-dependent Sec-independent / TTSS dependent<br />
MxiH<br />
MxiI<br />
MxiA,<br />
Spa40, 24, 29, 9, 13? MxiK, N MxiI Spa32 Secretion<br />
MxiJ<br />
inner rod Needle length<br />
Spa33,<br />
MxiG<br />
control/ of effector<br />
Spa 47 (ATPase) substr<strong>at</strong>e switch molecules<br />
Inner membrane ring<br />
Needle assembly and secretion<br />
From Abdelmounaim Allaoui
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