Shigella Effectors at Work - EMBO

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Antimicrobial molecules COMMENSALS Absence (limitation) of virulence factors PAMPs less agonist ? Sequestration, weak activity of TLRs Life in biofilms on mucus surface Controled diffusion and sampling of PAMPs And prokaryotic signalisation molecules TLR QSM MDP OCTN2 PepT1 ? Regulatory cascade NLR Regulatory genes Regulatory cytokines, chemokines Mucus Immature DC & MΦ M Treg DC PATHOGENS Mucinases Adhesins / Invasins Type III / IV secretory systems Hemolysins Massive engagement of TLRs, NLRs Eradication of commensal fmicrobiota (niche occupancy) + Dampening innate / inflammatory responses TLR PMN Pro-inflammatory cascade NLR Pro-inflammatory Pro-inflammatory genes Pro-inflammatory Pro-inflammatory cytokines, chemokines Activated DC & MΦ M Th1 / Th17 PMN
HISTOPATHOLOGY OF SHIGELLOSIS ELEMENTARY LESIONS IN HUMAN COLON SURFACE EPITHELIUM CRYPTS LUMEN ULCERATED ABSCESS MUSCULARIS MUCOSAE SUBMUCOSAL TISSUES Shigella flexneri : Endemic form Shigella sonnei : Endemic form Shigella dysenteriae 1 ( Shiga toxin) toxin) : Epidemic form Shigella boydii : Sporadic form
Page 1: Shigella effectors at work Invasion
Page 5 and 6: The Shigella invasion pathogenicity
Page 7 and 8: Posters of the III rd type: Marlise
Page 9 and 10: A. Zipper mechanism Invasin Yersini
Page 11 and 12: Alto et al. Ohya et al. IpgB ELMO/D
Page 13 and 14: IpaC last 72 aa fused to iota Ia co
Page 15 and 16: Rupture, invasion and inflammatory
Page 17 and 18: Adaptation of Shigella to the gut e
Page 19 and 20: GlcNAc O O CH O HCCH 3 CO CO CH 3 L
Page 21 and 22: cytokines chemokines Inhibition of
Page 23 and 24: 37°C Contact virF virB ipaC ipaB i

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