Collapse of polymer brushes grafted onto planar ... - Wageningen UR
Collapse of polymer brushes grafted onto planar ... - Wageningen UR
Collapse of polymer brushes grafted onto planar ... - Wageningen UR
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EFFECT OF MIXING OF TWO CHARGED PHOSPHOLIPIDS ON VESICLE SIZE AND<br />
MEAN BENDING MODULI<br />
M.M.A.E. Claessens, B.F. van Oort, F.A.M. Leermakers<br />
Laboratory <strong>of</strong> Physical Chemistry and Colloid Science, <strong>Wageningen</strong> University,<br />
Dreijenplein 6, 6703 HB <strong>Wageningen</strong>, The Netherlands<br />
email: mireille@fenk.wau.nl<br />
ABSTRACT<br />
The mean bending modulus, kc, <strong>of</strong> a bilayer <strong>of</strong> a surfactant mixture is expected to depend on the<br />
composition. It is usually assumed that kc decreases towards the equimolar composition. As the the<br />
size <strong>of</strong> entropically stabilized vesicles is related to kc, a decrease in kc will result in smaller vesicles.<br />
Previously we showed that both the anionic DOPC and the zwitterionic DOPG form vesicles that are<br />
stabilized by undulation entropy. Mixtures <strong>of</strong> these bilayer forming phospholipids indeed have a<br />
decreased equilibrium size compared to the pure component vesicles. SCF calculations were used<br />
to obtain kc for mixtures <strong>of</strong> chared surfactants. The predictions for kc correlate well with the experimentally<br />
found trends in vesicle radii. The changes in kc are not only due to the mixing <strong>of</strong> lipids,<br />
variations in charge density also affect kc.
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