AA.Gastric C II 06. ppt

GASTRIC ADENOCARCINOMA
Treatment. XIX.
Chemotherapy for advanced disease
* combinations of cytotoxic drugs to pts with
advanced GC reduces > 50% measurable tumor mass
in 30 - 50% of cases ("partial response"), with significant
clinical benefit;
- drug combinations generally include 5 - FU
(variously with doxorubicin, mitomycin - C, cisplatin,
high doses of methotrexate, irinotecan and
oxaliplatin);
* despite response, complete disappearances of
tumor masses uncommon, partial responses transient
and overall impact of multidrug therapy on survival
doubtful