Leica RM2125 RTS Manual Microtome - Wolf Laboratories

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The Essential Microtome
Leica RM2125 RTS Manual Microtome
Cut the high-quality sections that accurate diagnosis depends on. The
Leica RM2125 RTS manual microtome has the essential features you
need for safer economic sectioning and optimized workflows.

Quality is essential
When cutting sections from patient tissue, you want every section to count. The Leica RM2125
RTS utilizes the essential elements of proven Leica Microsystems’ technology to deliver
high-quality sectioning in an economical manual package.
• Accuracy – precise feed mechanism means precise sections
• Stability – PowerBase ensures stable operation for vibration-free sectioning
• Security – advanced knife holder and specimen clamp securely align cutting edge to block
Safety is essential
Because you don’t want to compromise on safety, the Leica RM2125 RTS doesn’t either. By
combining the essential elements of intuitive operation and advanced safety features, the Leica
RM2125 RTS helps microtomists work more safely throughout each shift.
• Only the essentials – with only the most important functions, complexity is reduced and
operation simplified
• For the user – user-selectable coarse feed wheel turn direction and retraction functions so
the microtome works for each individual user
• Added safety by design – a smooth running hand wheel, built-in safety guards and a
rounded instrument shape with arm rests for fatigue-free sectioning
Productivity is essential
With no time to waste, efficient sectioning is critical for overall laboratory productivity. The manual
Leica RM2125 RTS has the essential features for highly productive sectioning.
• Efficient set up – a quick-exchange specimen clamp and an 8° orientation system for the
object head allow rapid set up for any block
• Efficient operation – two trim steps (50 µm coarse, 10 µm fine) mean fast trimming so you
can produce sections sooner
• Efficient use of space – store essential tools and accessories on top of the microtome so
they are off the bench, and easy to access
Leica RM2125 RTS Technical Specifications
General Information
Section thickness setting range: 0.5 – 60 µm
Total horizontal specimen feed: 25 mm
Vertical specimen stroke: 59 mm
Specimen retraction: ON/OFF
Coarse feed wheel turn direction: User selectable
Specimen orientation: XY – 8°
Trimming thickness: 10 µm, 50 µm
Dimensions
Dimensions (W x D x H): 438 mm x 472 mm x 265 mm,17.24” x 18.58” x 10.43”
Weight: (without accessories): 29 kg, 63.9 lbs
Technical specifications subject to change.
The Leica RM2125 RTS has been designed and manufactured in compliance with IEC requirements.
Leica RM2125 RTS with PowerBase stability
Quick-exchange specimen clamp
8° orientation system
Two trim steps for efficient operation

Leica RM2235
The Manual Rotary Microtome For Outstanding Durability,
Precision and Comfort

As Durable as Ever, Enhanced Precision and Comfort
Like Never Before: The New Leica RM2235
Durability is essential in a manual microtome and the
Leica RM2235 can stand up to the workload requirements
of even the busiest laboratories. The enhanced precision
of the new accessories will add convenience to block to
knife approach as well as specimen orientation.
The new Leica RM2235 manual microtome provides
unique user-friendliness, achieved through numerous new
features, most of them patented, which have never before
been offered in this class of microtome. The Leica RM2235
combines proven technology with well thought-out ergonomic
details and the highest safety standards.
Working in comfort is not a luxury but a necessity. A re-
Program
laxed, ergonomic working posture is a basic prerequisite
for the high levels of speed, precision, and efficiency
required in modern laboratories. Day after day, the new
Histotechnology
Leica RM2235 provides comfortable functionality without
compromise. The RM2235 is the instrument of choice for
University
all clinical histology and histopathology institutions where
manual microtomes are preferred over motorized units. Indiana

The New Approach to Manual Sectioning
■ Fatigue-free operation
Ergonomics and user comfort were
prime considerations for the location
of the coarse feed wheel, which is
positioned close to the operator.
The direction of the handwheel rotation
to best suit your sectioning style
can be specified at the time an order
is placed. The mechanical trimming
function, conveniently placed next
to the coarse feed wheel, eliminates
the need to turn the coarse feed
wheel during trimming.
■ Spacious, magnetized section
waste tray
The spacious section waste tray
reliably collects sectioning debris.
It is safely held in position by
magnets, yet is easily removable for
emptying and cleaning.
Leica Design by Werner Hölbl
■ Safety during sectioning
Safety is ensured by the integrated,
red finger protection guard of the
knife holder E that uniquely shields
the blade edge. When used correctly
the integrated finger protection guard
rules out potential injuries because
it can even remain on the blade edge
during sectioning.
* not supplied with basic instrument
■ Convenient storage area
An integrated storage tray* ensures
that ancillary tools are on hand at all
times. Alternatively a cooling plate with
thermo element can be used for cold
storage of specimen blocks either on
top or on either side of the microtome.

■ Ergonomics and user safety
The smooth-running safety handwheel
has an ergonomically shaped handle.
A handwheel locking device for onethumb
operation locks the specimen
head in the uppermost position, which
is ideal for changing the specimen
and/or blade. A second locking mechanism
on the microtome base allows
the object head to be locked in any
position.
■ The patented force balancing
system
The RM2235 handwheel runs exceptionally
smoothly because it has no
balancing weight. Instead, the patented
force balancing system uses
a spring to compensate the forces
generated during sectioning. The
result: effortless operation and uniform
handwheel rotation – producing
much better sectioning results.
Leica-patented:
Spring-based force
balancing system
Conventional:
Handwheel with
balancing weight
■ Fast sectioning without specimen orientation
For applications where specimen orientation is not
needed, a non-orienting fixture for specimen clamps
is available as an optional accessory. The Super
Mega cassette can clamp specimens up to a size of
46 x 66 x 10 mm (W x H x D).
■ Precision specimen orientation with
clear zero reference point
This novel orientation mechanism sets new standards
of precision and is very easy to operate. Calibrated
controls make it easy to adjust a specimen to an exact
zero position indicated by red pins or a measurable
variable on the x/y axis for re-cuts.
■ Lateral knife holder adjustment
The entire width of the microtome blade can be used
without having to release the blade clamping mechanism.
Using the entire knife edge is cost effective, especially
in laboratories with high specimen throughput.
Three predefined stop positions (left, center, right)
correspond to the width of a standard histology cassette.
■ A special accessory:
Chilled universal cassette clamp (UCC)
The UCC is kept cold by placing ice cubes or dry ice in
a special compartment, which ensures that specimen
blocks remain at cold temperatures throughout the
entire sectioning process.
Well thought-out and proven:
Knife holder base
universal knife holder base fits virtually all Leica knife
holder systems.
Universal cassette clamp for single-hand operation
definitely THE easiest way to clamp/remove specimens.
Optimized microtome base plate
provides maximum rigidity – thanks to the latest technology
and new lightweight materials.
One-piece housing
made from specially resistant plastic, without any edges
where debris could accumulate, which reduces cleaning
to a minimum.
Fewer clamping levers
makes the Leica RM2235 easier to use by providing improved
access to the cutting area.

Technical Specifications
Section thickness
Setting range: 1 – 60 µm
Setting values: 1 – 10 µm in 1 µm increments
10 – 20 µm in 2 µm increments
20 – 60 µm in 5 µm increments
Section thickness indication: viewing window
Coarse feed: manual via coarse feed wheel
Trim settings: 10, 30 µm
Total horizontal specimen feed: approx. 30 mm
Vertical stroke: 70 mm
Specimen retraction: approx. 60 µm, can be deactivated
The Leica RM2235 features at a glance:
Precision specimen orientation with zero point reference
Compact, ergonomic overall design
User safety integrated into all aspects of the instrument
Ergonomically located coarse feed wheel for
fatigue-free operation
Extremely smooth-running handwheel due to
patented force compensation system
Two safety locking mechanisms on the handwheel
Precise knife holder lateral adjustment ensures
that the entire width of the blade edge can be used
Cooling plate (optional)
Maximum specimen size (W x H x D): 50 x 66 x 30 mm
Specimen orientation: horizontal: 8°
vertical: 8°
Dimensions
Width (including handwheel): 413 mm (16.26 in.)
Depth (including section waste tray): 618 mm (24.33 in.)
Height (with storage tray installed on housing): 305 mm (12.01 in.)
Weight (without accessories): approx. 34 kg, 75 lbs
A wide range of accessories is available upon request.
Technical specifications are subject to change without notice.
Certifications: CE, c-CSA-us
Up-to-date development, production and quality control procedures are certified under DIN
EN ISO 9001 to ensure highest quality and reliability.
Single-handed operation specimen clamps
Universal knife holder base for different knife holders
Disposable blade holder with integrated safety
finger protection guard
Spacious magnetized section waste tray
One-piece, easy-to-clean housing

Leica RM2245
The Manual Microtome with High-Precision Motorized Specimen Feed

The New Leica RM2245 – Efficiency
Goes Hand in Hand with Comfort
The new Leica RM2245 semi-motorized rotary microtome
represents the perfect combination of economic efficiency
and user comfort. It is the instrument of choice for clinical
histology and histopathology applications, as well as for
industrial quality assurance.
The Leica RM2245 is designed to meet the many requirements
of modern laboratories. This task is fulfilled without
compromise by combining proven technology and exemplary
safety standards with functionality and ergonomic
design.
Manual sectioning is enhanced by the high-precision motorized
specimen feed, which results in efficient operation
with maximum section reproducibility. Operator fatigue is
reduced through the use of the patented spring system,
which eliminates the need for a heavy counter balance
weight in the handwheel. Enhanced user comfort results
in maximum workplace efficiency and high specimen
throughput.
With the Leica RM2245 there is a choice between the
conventional manual sectioning method of full handwheel
rotation and the “rocking mode”. In rocking mode, the
handwheel is only turned back and forth over a short distance.
Every change in rotation direction is automatically
translated into a specimen feed or retraction movement.
Indiana University Histotechnology Program

The Useful Details Show a Great Design Concept
■ Safety during sectioning
Safety is ensured by the integrated,
red finger protection guard of the
knife holder E that uniquely shields
the blade edge. When used correctly
the integrated finger protection
guard rules out potential injuries
because it can even remain on the
blade edge during sectioning.
■ Comfortable operation
All functions are controlled via a compact,
space-saving control panel with
areas in contrasting colors and touchsensitive
buttons that allow ‘blind
operation‘. Panel inclination is adjustable,
and the panel can be positioned
either on the left or right side of the
instrument.
Leica Design by Werner Hölbl
■ Unobstructed work area
To provide improved access to the
cutting area, several clamping levers
that are not routinely used have
been replaced by hidden clamping
devices without compromising standard
setting options.
■ Convenient storage area
An integrated storage tray* ensures
that ancillary tools are on hand at all
times. Alternatively a cooling plate
with thermo element can be used
for cold storage of specimen blocks
either on top or on either side of the
microtome.
* not supplied with basic instrument

■ Easy to clean
Due to the rounded shape of the
Leica RM2245’s one piece housing,
section waste is easily removed.
The integrated slot cover prevents
debris from entering the internal
mechanisms of the microtome.
■ Spacious, magnetized section
waste tray
The spacious section waste tray reliably
collects sectioning debris. It is
safely held in position by magnets,
yet is easily removable for emptying
and cleaning.
■ Ergonomics and user safety
The smooth-running safety handwheel
has an ergonomically shaped
handle. A hand-wheel locking device
for one-thumb operation locks the
specimen head in the uppermost
position, which is ideal for changing
the specimen and/or blade. A second
locking mechanism on the microtome
base allows locking the object head
in any position.
■ Stability
Maximum rigidity and stability are
provided by the optimized microtome
base plate.
■ Precision specimen orientation with
clear zero reference point
This novel orientation mechanism sets new standards of precision
and is very easy to operate. An important detail: Calibrated
controls make it easy to adjust a specimen to an exact zero
position indicated by red pins or a measurable variable on the
x/y axis for re-cuts.
■ Lateral knife holder adjustment
The entire width of the microtome blade can be used without
having to release the blade clamping mechanism. Using the
entire knife edge saves costs, especially in laboratories with
high specimen throughput. Three predefined stop positions
(left, center, right) correspond to the width of a standard histology
cassette.
Well thought-out and proven
The Leica-patented Force Compensation System
for extremely smooth manual handwheel operation.
The Precision Micrometer Feed System
from 0.5 µm to 100 µm in sectioning mode and 1 µm to
600 µm in trimming mode via stepper motor.
The Leica Control Panel Concept
separate and intuitive control panel for instrument
settings and communication display integrated in the
instrument housing at eye level.
Accessories
a wide range of blade or knife holders and specimen
holders is available for a variety of applications.

Technical Specifications
Section thickness
Setting range: 0.5 – 100 µm
Setting values: from 0.5 – 5 µm in 0.5 µm-increments
from 5 – 20 µm in 1 µm-increments
from 20 – 60 µm in 5 µm-increments
from 60 –100 µm in 10 µm-increments
Trimming section
thickness setting range: 1 – 600 µm
Setting values: from 1 – 10 µm in 1 µm-increments
from 10 – 20 µm in 2 µm-increments
from 20 – 50 µm in 5 µm-increments
from 50 – 100 µm in 10 µm-increments
from 100 – 600 µm in 50 µm-increments
Object feed: 28 mm ±1 mm, feed motion
via step motor
Vertical specimen stroke: 70 mm
Sectioning modes: 2 manual modes (conventional full
handwheel rotation and rocking mode)
Specimen retraction: 5 – 100 µm in 5 µm-increments,
can be turned off
The Leica RM2245 features at a glance:
Precision specimen orientation with zero point reference
Compact, ergonomic overall design
Section thickness totalizer and section counter
Easy alternation between trimming and sectioning function
Two motorized forward and backward specimen
coarse feed speeds
Programmable specimen retraction
Low-maintenance cross roller bearings
Single-handed operation universal cassette clamp
Completely new knife holder concept for disposable
blades, with finger guard in contrasting color
Precise knife holder lateral movement
User safety integrated into overall design
Smooth-running handwheel with integrated
quick-lock mechanism
Electric coarse feed: 300 µm/s and 900 µm/s
Maximum specimen size (L x H x W): 50 x 60 x 40 mm
Specimen orientation: horizontal: 8°, vertical: 8°
Nominal supply voltages: 100/120/230/240 V AC ±10%
Nominal frequency: 50/60 Hz
Power draw: 70 VA
Dimensions basic instrument
Width (including handwheel): 413 mm
Depth (including waste tray): 618 mm
Height (with storage area on cover): 305 mm
Weight (without accessories): approx. 37 kg (87 lbs)
Dimensions control panel
W x D x H: 94 x 164 x 50 mm
Weight: approx. 0.450 kg (1 lb)
Wide range of accessories on request.
Technical specification subject to change.
Certificates: CE, c-CSA-us
Up-to-date development, production and quality control procedures certified
under DIN EN ISO 9001 to ensure highest quality and reliability.
Ergonomically optimized handwheel handle
Communication display integrated in instrument housing
Enclosed micrometer mechanism
Spacious magnetized section waste tray
Intuitive control panel
Wide range of accessories

Leica RM2255
Rotary Microtome for high-Performance Motorized and
Manual Sectioning

The New Leica RM2255 Rotary Microtome
High-performance is an important factor when considering
the quality of rotary microtomes. A modern microtome
must also offer safety, ergonomy, efficiency, and economy.
With this in mind, Leica Microsystems designs and
manufactures microtomes that set new standards in
today’s laboratory.
The new fully automated Leica RM2255 microtome embodies
the latest technological innovations in microtomy and per-
fectly harmonizes practical features with an ergonomic
design and user safety. Its two-in-one design concept,
which allows motorized as well as manual sectioning,
provides reproducible, quality sections.
The Leica RM2255 is a blend of proven high-performance,
precision microtome technology with all the added bene-
fits customers expect from the market leader in microtomy.
The attention to detail in this new microtome, part of the
Leica RM2200 family of quality microtomes, represents
another step in the advancement of innovative, user-
oriented microtomes.

■ Control panel
with colored, raised keys, allows
‘touch’ control so all of the operator’s
attention can be fully focused
on sectioning and section retrieval.
The panel has adjustable inclination,
a very small footprint, and can be
positioned to the left or right of the
instrument.
Leica Design by Werner Hölbl
■ Knife holder E
is our most popular knife holder and
accepts either high or low profile
disposable blades. For enhanced
safety, an integrated finger guard
covers the entire blade, even during
sectioning.
High-Performance Motorized a
■ Fewer clamping levers
permit unencumbered access to the
cutting area. The locking pins can
also be moved from one side to the
other and the levers can be repositioned
after locking to further clear
the work area.
■ Ample storage space:
on an integrated storage tray provides
plenty of space for your ancillary tools.
For cool storage of specimen blocks
right on the microtome, we recommend
the optional cooling tray with unique
cooling blocks.
■
co
an
pra
Th
sp
co
fas
■
c
p
tr
m
th
c

nd Manual Sectioning Sets New Standards!
ne-piece housing,
bines ergonomics, aesthetics
ease-of-use while meeting the
ctical requirements of the lab.
one-piece housing, made from
cially resistant plastic, allows
fortable access to controls and
t and easy cleaning.
Spacious, integrated section
waste tray
onveniently prevents scattering of
araffin debris. The section waste
ay is securely held in position by a
agnet, but is easy to remove from
e instrument for emptying and
leaning.
■ Safe, smooth-running handwheel
features a new ergonomic handle, a
traditional lock that locks anywhere
in the rotation, and a new easy
access, quick-lock device to lock the
specimen in the uppermost position.
For motorized sectioning, the handwheel
handle can be centered.
Safety is Leica’s number one priority.
■ Stable microtome base plate
was designed using the latest technology
and materials to produce a
robust, stable, yet lightweight support
for the precision microtome
mechanisms.
■ Precise specimen orientation
sets new standards of precision in rotary microtomes. With the
use of calibrated controls and visual aids, it is simple to adjust
the specimen to an exact zero point or in measurable variables
of up to 8° along the x-y axis.
■ Lateral knife holder adjustment
allows the use of the entire length of the blade without having to
change the tension setting. Three predefined stop positions (left,
center, right) that correspond to the width of a standard histology
cassette may be used if desired.
Proven Technology:
Leica’s patented gravitational force
compensation system
makes rotating the handwheel extremely smooth and
light, which is especially beneficial during manual
sectioning applications.
Precise micrometer feed system
permits precision sectioning from 0.5 µm to 100 µm
via the use of a stepper motor and low-maintenance,
cross-roller bearings.
Powerful sectioning motor
is rugged enough for sectioning most hard specimens
without producing sectioning artifacts.
Specially designed electronics system
allows flexible operation of the instrument while
providing precision control over the specimen
advance and cutting speeds.
Universal knife holder base
is compatible with all routine Leica RM2200 series
microtome knife holder systems that require a base.
One-hand operated universal cassette clamp
is definitely THE easiest way to clamp and remove
specimens.

Technical Specifications
Section thickness:
Section thickness setting range: 0,5 – 100 µm
Setting values: from 0,5 µm – 5 µm in 0,5 µm-increments
from 5 – 20 µm in 1 µm-increments
from 20 – 60 µm in 5 µm-increments
from 60 –100 µm in 10 µm-increments
Trimming section
thickness setting range: 1 – 600 µm
Setting values: from 1 – 10 µm in 1 µm-increments
from 10 – 20 µm in 2 µm-increments
from 20 – 50 µm in 5 µm-increments
from 50 – 100 µm in 10 µm-increments
from 100 – 600 µm in 50 µm-increments
Object feed: 28 mm ±1 mm, feed motion via
step motor
Vertical specimen stroke: 70 mm
Sectioning modes: 4
Specimen retraction:
in manual operation: 5 – 100 µm in 5 µm-increments,
can be turned off
in motorized operation: varying with the sectioning
speed, can be turned off
Electric coarse feed: 300 µm/s und 900 µm/s
Sectioning speed: 0,5 – 420 mm/s ± 10%
The Leica RM2255 Features at a Glance:
Compact, ergonomic design
Ergonomically designed handwheel handle
Smooth-running handwheel with integrated quick-lock
mechanism for safety
Enclosed micrometer feed mechanism
Low-maintenance cross-roller bearings
Two forward and backward coarse feed speeds
Alternate trimming and sectioning modes, as indicated
on the display
Speed control through the cutting window for enhanced
efficiency
Automatic, variable specimen retraction, depending on
sectioning speed
Section thickness totalizer and section counter
Intuitive control panel
Integrated communication display
Precise specimen orientation with zero point reference
Maximum specimen size (L x H x W): 50 x 60 x 40 mm
Specimen orientation: horizontal: 8°, vertical: 8°
Nominal supply voltages: 100 / 120 / 230 / 240 V AC ±10%
Nominal frequency: 50/60 Hz
Power draw:
Dimensions basic instrument
340 VA
Width (including hand wheel) 413 mm
Depth (including waste tray) 618 mm
Height (with storage area on cover): 305 mm
Weight (without accessories)
Dimensions control panel
approx. 37 kg, approx. 81 lbs
WxDxH: 121 x 166 x 50 mm
Weight: approx. 0.66 kg, approx. 1.45 lbs
Wide range of accessories on request.
Technical specification subject to change.
Certificates: CE, c-CSA-us
Up-to-date development, production and quality control procedures certified
under DIN EN ISO 9001 ensure highest quality and reliability.
One-hand operated universal cassette clamp
Completely new knife holder design with red colored
knife guard
Precise lateral knife holder adjustment with click stop
settings
Spacious and easy-to-clean section waste tray
Wide range of accessories

Leica RM2265
The Fully Motorized, Programmable Rotary Microtome

When it comes to selecting a microtome, many factors
have to be taken into consideration and it's hard to decide
which factor is the most important: reliability, innovative
technology, efficiency, ergonomics or safety. Leica
believes that each of these aspects is equally essential for
the most crucial requirement a modern microtome has to
meet: Versatility.
Leica Microsystems offers a microtome that can satisfy
all of your laboratory’s requirements: the fully motorized,
versatile Leica RM2265 rotary microtome. It is the top-ofthe-line
product in the Leica RM2200 rotary microtome
series and is designed to produce superior sections of a
multitude of specimen types with ease. Its outstanding
technology allows it to be used for semi-thin to thick sectioning
of soft or hard specimens; routine as well as special
biomedical research applications; and industrial quality
assurance and materials research applications.
Whether your instrument requirements are dedicated to a
single discipline or demand the versatility to perform in multiple
disciplines, the Leica RM2265 provides the perfect
solution for achieving constant, high-performance workflow
in your laboratory. And instead of compromising one
advantage for another, the Leica RM2265 allows you to benefit
from all of the latest state-of-the-art-technology in modern
microtomy.
With the Leica RM2265, a total of six sectioning modes are
is available. In motorized operation there are four operating
mode selections: continuous, single or step stroke, and
program mode. In manual operation it is possible to use
the conventional method of completing a full handwheel
rotation or the intuitive “rock” mode. When the handwheel
is moved back and forth over a small distance, each
change in direction is electronically detected and automatically
converted into an advance or retraction movement
of the specimen arm.
Versatility Without Compromise:
The Leica RM2265

A Sophisticated Approach to Versatility
■ Control panel operation
The automated functions of the
microtome are controlled via a separate,
compact control panel. Controls
for specific functions are
grouped together and the most used
areas contain contrasting colors
and touch-sensitive buttons that
allow “blind operation”. Panel inclination
is adjustable, and the panel
can be positioned either on the left
or right side of the instrument.
Leica Design by Werner Hölbl
■ Utmost versatility for many
special requirements
A wide choice of optional accessories
includes a microscope carrier
with two fiber optic light guides for
the optimal illumination of the knife
and specimen.
■ Unobstructed work area
To provide improved access to the
cutting area, hidden clamping
mechanisms have replaced several
clamping levers that are not routinely
used, without compromising
the standard setting options.
■ Easy-to-clean
Due to the rounded sha
Leica RM2265’s one-piece
section waste is easily
The integrated slot cover
debris from entering th
mechanisms of the micro

pe of the
housing,
removed.
prevents
internal
tome.
■ Ergonomics and user safety
The smooth-running safety handwheel
has an ergonomically
shaped handle. A handwheel locking
device for one-thumb operation
locks the specimen arm in the
uppermost position, which is ideal
for changing the specimen and/or
blade. A second locking mechanism
on the microtome base allows
locking the object head in any position.
During motorized sectioning,
activation of the emergency stop
button located on the instrument
will immediately halt the movement
of the specimen arm.
■ Stability
The optimized microtome base
plate provides maximum rigidity
and stability.
■ Magnetized section waste tray
The section waste tray is safely held
in position by magnets, yet is easily
removable for emptying and cleaning.
If needed, a larger waste tray is
optionally available for applications
with a high amount of sectioning
debris.
■ Precise specimen orientation with clear zero
reference point
This novel orientation mechanism sets new standards
of precision. Guided by visual indicators, the
adjustment of calibrated controls makes it easy to
orient a specimen to an exact zero position or to a
measurable variable on the x/y axis.
■ Universal knife holder base
The knife holder base is suitable for holding various
disposable blade or reusable knife holders, making
it possible to section a variety of specimen types.
■ Leica LN22 freezing device
The low temperature sectioning system has been
specifically designed for use with the Leica RM2265
microtome. Even the most demanding specimen can
be precisely sectioned in a thickness range from
0.25 µm to 100 µm at temperatures down to –150 °C.
Well thought-out and proven
Leica-Patented Force Compensation System
provides extremely smooth manual handwheel operation.
Precision Micrometer Feed System
provides semi-thin to thick sectioning via stepper motor from
0.25 µm to 100 µm in sectioning mode and 1 µm – 600 µm in
trimming mode.
Integrated, Intuitive Display
conveniently displays instrument settings and performance
information at eye level.
Wide Range of Accessories
tailors the Leica RM2265 to meet individual needs and optimizes
the sectioning performance of any specimen, e.g., a
wide assortment of holders for any type of knife or disposable
blade and specimens of every shape; stereomicroscope
carrier; widefield magnifier; or Leica LN22 liquid
nitrogen freezing device.

Leica RM2265 – Technical Specifications
Section thickness:
Section thickness
setting range: 0.25 µm – 100 µm
Setting values: 0.25 µm
from 0.5 – 5.0 µm in 0.5 µm increments
from 5 – 20 µm in 1 µm increments
from 20 – 60 µm in 5 µm increments
from 60 – 100 µm in 10 µm increments
Trimming section thickness
setting range: 1 – 600 µm
Setting values: from 1 – 10 µm in 1 µm increments
from 10 – 20 µm in 2 µm increments
from 20 – 50 µm in 5 µm increments
from 50 – 100 µm in 10 µm increments
from 100 – 600 µm in 50 µm increments
Specimen retraction:
Manual Operation programmable from 5 – 100 µm in 5 µm
increments; can be turned off
Motorized Operation: varying with the sectioning speed;
can be turned off
Electronic coarse feed: 300 µm/s or 900 µm/s
Sectioning speed range: 0.5 – 420 mm/s
Horizontal specimen feed: approx. 30 mm
The Leica RM2265 features at a glance:
Compact, ergonomic overall design
User safety integrated into the microtome and
accessories
Intuitive control panel
Automatic, variable specimen retraction, depending
on sectioning speed
Two motorized forward and backward specimen
coarse feed speeds
Two separate programs for trimming and
sectioning mode
Speed control through the cutting window for
enhanced efficiency
Programmable vertical object head stop position,
especially ideal for the LN22
Communication display integrated in instrument housing
Section thickness setting of 0.25 µm to 100 µm
Section thickness totalizer and section counter
Vertical specimen stroke: 70 mm
Sectioning modes: 6 total
2 manual modes
(regular and rocking mode)
4 motorized modes
(continuous, single or step stroke,
and program mode)
Maximum specimen size (L x H x W): 50 x 60 x 40 mm (1.96 x 2.36 x 1.57 in.)
Specimen orientation: horizontal: 8°, vertical: 8°
Power draw max: 340 VA
Nominal supply voltages: 100 V / 120 V / 230 V / 240 V
Nominal frequency: 50/60 Hz
Dimensions basic instrument
(L x W x H): 563 x 413 x 305 mm (22.16 x 16.25 x 12 in.)
(without magnifier or microscope
carrier)
Weight (without accessories) approx. 37 kg (approx. 81 lbs)
Dimensions control panel
(W x D x H): 121 x 166 x 50 mm (4.76 x 6.53 x 1.96 in.)
Weight: approx. 0.68 kg (approx. 1.45 lbs)
Wide range of accessories on request. Technical specification subject to change.
Certificates: CE, c-CSA-us
Up-to-date development, production, and quality control procedures certified under
DIN EN ISO 9001 to ensure the highest quality and reliability.
Smooth-running handwheel with integrated
quick-lock mechanism
Ergonomically optimized handwheel handle
Low-maintenance cross roller bearings
Enclosed micrometer mechanism
Precision specimen orientation with zero point
reference
Magnetized section waste tray
Wide range of accessories for special applications