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Bui Lecture.pdf

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Corollary to Cancer Immunoediting: Tumorigenesis<br />

must induce immune recognition<br />

Normal Cells<br />

Not recognized<br />

Tumorigenesis<br />

?<br />

Transformed Cells<br />

Well recognized<br />

-Are there molecules that are induced by tumorigenesis that<br />

mediate immune recognition? What are the signals that control<br />

the expression of these molecules?<br />

-How likely is it that tumorigenesis induces immune recognition?<br />

-What cells recognize nascently transformed tumors?

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