Bui Lecture.pdf

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Immune cells function to eliminate tumor Immunogenic tumor cells undergo elimination Immune cells function to facilitate tumor progression Immunoevasive tumor cells co-opt inflammatory signals The immune system performs tumor surveillance Inflammation induced cancer Figure 1 : The anti-tumor response represents a unique model for studying cell fate decisions. Unresolved questions include: Which immune cells/effector molecules participate in cancer immunosurveillance/immunoediting and/or tumor promoting inflammation? What characteristics of the tumor influence the function of infiltrating immune cells? How can immune function be harnessed for clinical benefit? <strong>Bui</strong> et al., Curr Op Imm, 2007
Goals 1. Present evidence that the immune system can perform tumor immunosurveillance. Define cancer immunoediting. 2. Present evidence that the immune system can promote tumor formation. 3. How does carcinogenesis affect immune function? 4. Will tumor immunotherapy have greater success?
Page 1 and 2: Tumor Immunology Jack Bui, MD, PhD
Page 4 and 5: Tumor immunology = the study of wha
Page 8 and 9: Figure 15.12d The Biology of Cancer
Page 10 and 11: The birth of tumor immunosurveillan
Page 12: Paradigm shift : Cancers are opport
Page 15: Shankaran et al., Nature 2001 Mice
Page 18 and 19: The presence of tumor specific T ce
Page 20 and 21: Evidence for tumor immunosurveillan
Page 22 and 23: Shown is survival in ovarian cancer
Page 24: Endogenous T Cell Responses to Anti
Page 28 and 29: Goals 1. Present evidence that the
Page 30 and 31: Shankaran et al., Nature 2001 WT tu
Page 32 and 33: Cancer immunoediting: regressor tum
Page 35 and 36: Evidence for equilibrium • Human
Page 37 and 38: Melanoma complicating treatment wit
Page 39 and 40: Implications of equilibrium state
Page 41 and 42: Inflammation and Cancer: “Cancers
Page 43 and 44: Evidence for inflammation induced c
Page 45 and 46: Deletion of the NF-kB activator IKK
Page 47 and 48: Goals 1. Present evidence that the
Page 49 and 50: Evidence for Cancer Immunoediting:
Page 51 and 52: Normal cell Not recognized Induced-
Page 53 and 54: Gasser et al., DNA damage induces N
Page 55 and 56: Evidence for p53’s role in activa
Page 57 and 58:
Corollary to Cancer Immunoediting:
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Passenger mutations leading to neo-
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Oncogene-driven models of cancer ca
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Goals for this hour 1. Present evid
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What cells/molecules promote vs inh
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Immune therapy of melanoma • IL-2
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Peripheral blood mononuclear cells
Page 74 and 75:
An example of immunotherapy
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The presence of tumor specific T ce
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Can we remove immune suppression?
Page 81 and 82:
Cancer immunoediting describes the
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Some major unanswered questions •
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