Bui Lecture.pdf
Bui Lecture.pdf
Bui Lecture.pdf
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Evidence for p53’s role in activating<br />
• Xue et al. Nature. (2007).<br />
the immune system<br />
p53 restoration in vivo in liver carcinomas<br />
→ Chemokines↑ immune cells recruitment↑ but no increase in apoptosis<br />
• Krizhanovsky. Cell. (2008).<br />
Senescence in hepatic stellate cells in vitro increases MICA and ULBP2<br />
transcripts (also increases other NK cell ligands)<br />
• Vassilev (Personal communications)<br />
p53 induces production of IL-6 and IL-8<br />
• Munoz-Fontela et al. Oncogene. (2005).<br />
Extra copy of p53 gives rise to mice with “super” anti-viral immunity
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