Bui Lecture.pdf

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Conclusions: 1. Vaccination with DCs loaded with killed allogeneic melanoma cells is safe, can elicit melanoma-specific CD8+ T cell immunity, and can lead to induction of long-lasting objective clinical responses. 2. Results warrant large-scale clinical studies in patients with metastatic melanoma and in patients with other types of cancer.
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Tumor Immunology Jack Bui, MD, PhD
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Tumor immunology = the study of wha
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Immune cells function to eliminate
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Figure 15.12d The Biology of Cancer
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The birth of tumor immunosurveillan
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Paradigm shift : Cancers are opport
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Shankaran et al., Nature 2001 Mice
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The presence of tumor specific T ce
Page 20 and 21: Evidence for tumor immunosurveillan
Page 22 and 23: Shown is survival in ovarian cancer
Page 24: Endogenous T Cell Responses to Anti
Page 28 and 29: Goals 1. Present evidence that the
Page 30 and 31: Shankaran et al., Nature 2001 WT tu
Page 32 and 33: Cancer immunoediting: regressor tum
Page 35 and 36: Evidence for equilibrium • Human
Page 37 and 38: Melanoma complicating treatment wit
Page 39 and 40: Implications of equilibrium state
Page 41 and 42: Inflammation and Cancer: “Cancers
Page 43 and 44: Evidence for inflammation induced c
Page 45 and 46: Deletion of the NF-kB activator IKK
Page 47 and 48: Goals 1. Present evidence that the
Page 49 and 50: Evidence for Cancer Immunoediting:
Page 51 and 52: Normal cell Not recognized Induced-
Page 53 and 54: Gasser et al., DNA damage induces N
Page 55 and 56: Evidence for p53’s role in activa
Page 57 and 58: Corollary to Cancer Immunoediting:
Page 59 and 60: Passenger mutations leading to neo-
Page 61 and 62: Oncogene-driven models of cancer ca
Page 63 and 64: Goals for this hour 1. Present evid
Page 65 and 66: What cells/molecules promote vs inh
Page 67 and 68: Immune therapy of melanoma • IL-2
Page 69: Peripheral blood mononuclear cells
Page 75 and 76: Chao, Weissman, Majeti Cell 2010
Page 77 and 78: Hong, Rosenberg, Sherry Clin Can Re
Page 80 and 81: Improved Survival with Ipilimumab i
Page 82 and 83: Take home messages • Tumor immuno
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