New Entities in Smoking Related Lung Disease
New Entities in Smoking Related Lung Disease
New Entities in Smoking Related Lung Disease
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Journal of Thoracic Oncology 2011; 6: 244-285<br />
Pathology Recommendation 1<br />
• “We recommend discont<strong>in</strong>u<strong>in</strong>g the use<br />
of the term “BAC”<br />
– Five situations where it is used:<br />
• Current WHO def<strong>in</strong>ition (lacks <strong>in</strong>vasion)<br />
• Lesions with small regions of <strong>in</strong>vasion<br />
• Lesions with predom<strong>in</strong>ant surface growth but<br />
central <strong>in</strong>vasive component<br />
• Lesions with prom<strong>in</strong>ent <strong>in</strong>vasive component<br />
and peripheral alveolar surface growth<br />
• In muc<strong>in</strong>ous tumors (with <strong>in</strong>vasion)<br />
Classification: Summary<br />
• Elim<strong>in</strong>ate bronchioloalveolar carc<strong>in</strong>oma<br />
• Def<strong>in</strong>e adenocarc<strong>in</strong>oma <strong>in</strong> situ<br />
• Def<strong>in</strong>e m<strong>in</strong>imally <strong>in</strong>vasive adenocarc<strong>in</strong>oma<br />
• Resurrect the term “lepidic”<br />
• Promote comprehensive histologic subtyp<strong>in</strong>g<br />
• Emphasize micropapillary carc<strong>in</strong>oma<br />
• Detach muc<strong>in</strong>ous adenocarc<strong>in</strong>omas<br />
• Discourage term NSCLC – subclassify if possible<br />
Journal of Thoracic Oncology. 6(2):244-285, February 2011.<br />
5/28/2011<br />
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