ReOss® Powder - Intra-Lock

ReOss ® Powder
Indication
ReOss ® is indicated for use in filling and/or augmenting intraoral/maxillofacial osseous defects; such as infrabony/intrabony
periodontal osseous defects, furcation defects, alveolar ridge osseous defects, tooth extraction sites and in sinus elevation
procedures.
Sub-Micron HA Particles
can begin to be seen permeating the
PGLA Matrix at 50,000x.
Red highlights are used here
as visual aid.
SEM Image of ReOss ® Biocomposite
300x Showing Internal Structure
of an Individual Granule
ReOss® Sub-Micron HA Infused Synthetic Biomaterial
ReOss® has a multi-pore three-dimensional architecture that
creates an environment for new bone growth. The scaffold
also provides a hospitable adhesive substrate that serves as a
strong physical support for the infusion and growth of bone
cells. The entire structure is an intricate, highly interconnected
matrix with enhanced hydrophilic properties. Through a
HA
HA
HA
HA
SEM Image of ReOss ® Biocomposite
10,000x Showing Porous Nature
of the PLGA Matrix
patented process utilizing barosynthesis, the biomaterial’s
highly porous, synthetic polymer foam is permeated with
osteoconductive sub-micron sized particles of HA. ReOss’s
bone-like foam scaffold, osteoconductivity, and increased
hydrophilic surface provide an environment for the
stimulation of bone regeneration.
Technical Properties
ReOss
ReOss®
Bone
Bone
Growth
Growth
Initiator
Initiator
is a
is
high
a high
purity
purity
biocomposite
biocomposite
which
which
is synthesized
is synthesized
utilizing
utilizing
a special
a special
process
process
involving
involving
high
high
pressure pressure formation. formation.
Typical Composition
Purity
Porosity
Pore Size
Particle Size Size
Resorption Time Time
50% Hydroxyapatite (Ca ( Ca10(PO4)6 10(PO4) 6(OH) (OH)2) 2)
50% Poly(lactide-co-glycolide)
< 70 %
Macropores = 15-300 150- 300 microns
Micropores < ≤10 10 microns
300-750 500 -1000 Microns microns
From 6 to 12 Months
Available Configurations Catalogue No. No. Volume
Reference List
ReOss® ReOssPowder: Powder:
ReOss® ReOssPutty: Putty:
ReOss ReOss® Injectable Gel:
1. 1. Poly Poly (lactide-co-glycolide)/hydroxyapatite (lactide-co-glycolide)/hydroxyapatite composite composite scaffolds for bone tissue tissue engineering. engineering. Kim Kimet et
al.
al.
Biomaterials
Biomaterials
27(2006)
27(2006)
1399-1409.
1399-1409.
2. A poly (lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity.
2. A poly (lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity.
Kim et al. Journal of Biomedical Research Part A Vol 80A Issue 1, pp 206-215.
Kim et al. Journal of Biomedical Research Part A Vol 80A Issue 1, pp 206-215.
3. Comparison of Osteogenic Potential Between Apatite-Coated Poly (lactide-co-glycolide)/Hydroxy
apatite 3. Comparison Particulates of Osteogenic and Bio-Oss. Potential Kim et Between al. Dental Apatite-Coated Materials Journal Poly 2008; (lactide-co-glycolide)/Hydroxy-
27(3): 368-375.
4.
apatite
Peripheral
Particulates
nerve regeneration
and Bio-Oss.
within
Kim et al.
an
Dental
asymmetrically
Materials
porous
Journal
PLGA/
2008;
Pluronic
27(3): 368-375.
F127 nerve guide
conduit. 4. Peripheral Oh et nerve al. Biomaterials regeneration 29(2008) within 1601-1609
an asymmetrically porous PLGA/ Pluronic F127 nerve guide
5. conduit. Sterilization, Oh ettoxicity, al. Biomaterials biocompatibility 29(2008) 1601-1609 and clinical applications of polylactic acid/polyglycolic acid
copolymers.
5. Sterilization,
Athanasiou
toxicity, biocompatibility
et al. Biomaterials
and
17
clinical
(1996)
applications
93-102
of polylactic acid/polyglycolic acid
6. copolymers. In vitro biocompatibility Athanasiou et of al. bioresorbable Biomaterials 17 polymers: (1996) 93-102 poly(L-lactide) and poly(lactide-co-glycolide).
A. Ignatius, L. E. Claes Biomaterials, Volume 17, Issue 8, 1996, Pages 831-839
6. In vitro biocompatibility of bioresorbable polymers: poly(L-lactide) and poly(lactide-co-glycolide).
A. Ignatius, L. E. Claes Biomaterials, Volume 17, Issue 8, 1996, Pages 831-839
RP-1 0.5cc 0.5 cc
RP-3 RP-3
1cc 1cc
RP-2 0.5cc 0.5 cc
RP-4 RP-4
1cc1
cc
RG-1 0.5cc 0.5 cc
RG-2 RG-2
1cc1
cc
Color coded
container caps
for easier
product recognition
••••••
SUB-MICRON HA INFUSED SYNTHETIC BIOMATERIAL
7. 7. Biodegradation Biodegradation and and biocompatibility biocompatibility of of PLA PLA and and PLGA PLGA microspheres. James M. Anderson, Matthew Matthew S. S.
Shiva
Shiva
Advanced
Advanced
Drug
Drug
Delivery
Delivery
Reviews
Reviews
Volume
Volume
28,
28,
Issue
Issue
1,
1,
13
13
October
October
1997,
1997,
Pages
Pages
5-24
5-24
8. Resorbability of bone substitute biomaterials by human osteoclasts. Schilling et al. Biomaterials,
8. Resorbability of bone substitute biomaterials by human osteoclasts. Schilling et al. Biomaterials,
Volume 25, Issue 18, Aug 2004, pp 3963-3972.
Volume 25, Issue 18, Aug 2004, pp 3963-3972.
9. The biodegradation of hydroxyapatite bone graft substitutes in vivo. Rumpel et al. Folia Morphology
9. Volume The biodegradation 65, No 1, pp 43-48 of hydroxyapatite bone graft substitutes in vivo. Rumpel et al. Folia Morphology
Volume
10. Biocompatibility
65, No 1, pp 43-48
of Scaffold Components and Human Bone Fetal Cells. Montjovent et al. European
10. Cells Biocompatibility and Material Vol.5. of Scaffold Suppl. Components 2,2003 p.79 and Human Bone Fetal Cells. Montjovent et al. European
Cells 11. Biodegradable and Material Vol.5. and Suppl. bioactive 2,2003 porous p.79polymer/inorganic
composite scaffolds for bone tissue
11.
engineering.
Biodegradable
Rezwan
and
et
bioactive
al. Biomaterials
porous polymer/inorganic
27(2006) 3413-3431
composite scaffolds for bone tissue
engineering. 12. Physico/Chemical Rezwan et characterization, al. Biomaterials 27(2006) in vitro and 3413-3431 in vivo evaluation of ReOss® and Synthograft
particulate grafting materials. Coimbra et al.
12. Physico/Chemical characterization, in vitro and in vivo evaluation of ReOss and Synthograft
particulate grafting materials. Coimbra et al.

Barosynthesized BioComposite
• 100% Synthetic
• Osteo Adhesive Topography
• Strong 3-D Scaffold
• Osteoconductive
• Enhanced Hydrophilicity
ReOss® is hydrophilic and configured as a multi-pore three-dimensional scaffold engineered to integrate with the
physiochemical state of bone tissue.
Overview of ReOss®: A Resorbable Bone-like Biocomposite PLGA/HA:
Poly (lactic-co-glycolic) acid / Hydroxyapatite
ReOss® is a composite biomaterial comprised of two phases - a PLGA biodegradable polymer and a bioceramic. The polymer
provides a structurally stable, porous and biocompatible 5,6,7 three-dimensional matrix to which biological fluids can penetrate,
and cells can adhere.The HA bioceramic, due to its chemical and structural similarity to the mineral phase of native bone, allows
the biocomposite to create a bond with the living host bone. 2,11
Sub-Micron-HA Particles
In order to improve the bioactivity of the ceramic phase, ReOss® utilizes Sub-Micron-sized particulate Hydroxyapatite (HA).
This particulate size HA shows improved osteointegration and faster degradation times over larger particulate HA, which
can impede bone growth because of its slow biodegradation. 1,2 Sub-Micron-sized HA also has been reported to augment
protein adsorption and cell adhesion, further improving the ability for bone to regenerate. 2
Multi-pore Resorbable Structure
The porosity of the polymer matrix of ReOss® also provides an excellent environment to aid in stimulating bone regeneration.
Through a patented process involving high-pressure formation of the polymer matrix, ReOss® is replete with both macro and
micropores. The micropores allow biological fluids and small molecules, which aid in cell growth to perfuse the matrix,
enveloping and sustaining the osteogenic cells that attach to the macropores of the scaffolds. As the cells begin to grow and
develop, both phases of the biocomposite degrade, leaving behind a stable, natural bone matrix. 7,8,9
Osteodynamics
Several studies have shown that biodegradable polymer/bioceramic composites can improve bone regeneration as
compared with conventional composites by optimizing controlled resorption, osteogenesis and osteointegration. 1,2,11 By
controlling the parameters which determine the characteristics of resorption and osteoinductivity, ReOss® provides a superior
vector for the stimulation of new bone growth.
GLOBAL HEADQUARTERS
6560 West Rogers Circle, Bldg. 24
Boca Raton, Florida 33487 USA
GLOBAL Tel: 877-330-0338
HEADQUARTERS
www.intra-lock.com • info@intra-lock.com
6560 West Rogers Circle, Bldg. 24 • Boca Raton, Florida 33487 USA
Tel: 877-330-0338
www.intra-lock.com • info@intra-lock.com
Intra-Lock
Intra-Lock® is registered trademark of Intra-Lock® International, Inc.
U.S. & Foreign Patents Pending.
® and ReOss ® are registered trademarks of Intra-Lock ® International, Inc.
U.S. & Foreign Patents Pending.
GLOBAL HEADQUARTERS
6560 West Rogers Circle, Bldg. 24 • Boca Raton, Florida 33487 USA
Tel: 877-330-0338
www.intra-lock.com • info@intra-lock.com
Intra-Lock® is registered trademark of Intra-Lock® International, Inc.
U.S. & Foreign Patents Pending.
CE 0499 0499 • EC • Rep: EC Rep: Intra-Lock System Europa, Spa., Srl., I-84100 Salerno • • © © Copyright 2008, 2009, Intra-Lock® Intra-Lock System International • S4EN-08-10CE
0499 • EC Rep: Intra-Lock System Europa, Spa., I-84100 Salerno • © Copyright 2008, Intra-Lock® System International • S4EN-08-10
® CE
System International • S4EN-09-07
SUB-MICRON HA INFUSED SYNTHETIC BIOMATERIAL