2012 Program Booklet - MCD Biology - University of Colorado Boulder

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Peter Jackson, PhD Staff Scientist: Research Oncology Genentech Saturday, October 13 4:00 – 4:45 pm JSCBB Butcher Auditorium Research Focus: My laboratory has worked on the biochemistry of the cell cycle, including DNA replication and mitosis. Much of our effort has gone toward understanding how proteolytic degradation by the ubiquitin proteasome system regulates the cell cycle. We have made key contributions to understanding how proteins that regulate the cell cycle, called cyclins, accumulate and are destroyed in vertebrate cells and in eggs. A central finding was our discovery of inhibitors of E3 ubiquitin ligases and their role in cell cycle control. We have identified several critical factors regulating cyclins and have linked their misregulation to cancer, proliferative disease and senescence. We continue to define important regulators in mitosis and in the ubiquitin pathway. Our recent work has also focused on signaling through the primary cilium. The primary cilium is an organelle with critical roles in signaling in tissues including the retina, nervous system, kidney and sensory organs. The importance of the cilia in signaling was only recently appreciated, but this structure organizes a still unknown number of receptor systems. These pathways are genetically linked to important degenerative diseases including renal cystic disease, obesity, diabetes, retinopathies and cancer signaling. We have used proteomic approaches to define regulatory networks linked to proteins that are defective in human diseases called ciliopathies. We are looking for critical receptor classes linked to these diseases and evaluating the therapeutic opportunities presented by these receptors
William Sullivan, PhD Professor, Department of Molecular, Cell & Developmental Biology University of California, Santa Cruz (UCSC) Title: Wolbachia, African River Blindness, and Big Sur Saturday, October 13 4:45 – 5:30 pm JSCBB Butcher Auditorium Abstract: Wolbachia are obligate, intracellular, bacterial endosymbionts present in over 60% of all insect species. Manipulation of host reproduction and efficient maternal transmission have facilitated the global spread of Wolbachia in arthropods. Wolbachia are also present in filarial nematodes and are the leading cause of River Blindness and Elephantiasis. Our lab has focussed on the molecular and cellular interactions that mediate Wolbachia replication and transmission through insect and nematode germlines. Our studies demonstrate that efficient germline transmission of Wolbachia requires a developmentally coordinated association with plus and minus end motor proteins followed by a stable association in conserved germline determinants. In addition, Wolbachia manipulates host chromatin remodelers and the cell cycle to its advantage. Surveys of wild Drosophila populations reveals Wolbachia also stably populates host somatic lineages including the adult brain. Consequently we were able to generate stably Wolbachiainfected Drosophila cell lines. This facilitated high-‐throughput cell-‐ based screens for small molecule compounds that specifically target Wolbachia. We descrbe the identification of Albendazole sulfone, an FDA approved metabolite of Albendazole, that specifically disrupts Wolbachia replication in Brugia malayi, the nematode associated with Elephantiasis and River Blindness.
Page 1 and 2: 26 TH MCDB Graduate Student Symposi
Page 3 and 4: Past MCDB Graduate Student Symposia
Page 5 and 6: Keynote Speaker: William Freytag, P
Page 7 and 8: Keynote Speaker: Larry Gold, PhD Ch
Page 9 and 10: William S. Marshall, PhD President
Page 11 and 12: JoAnne Flynn, PhD Professor, Depart
Page 13: Jeffrey Settleman, PhD Senior Direc
Page 17 and 18: Symposium Location Jennie Smoly Car
Page 19 and 20: 2012 PRESENTING SPONSORS Arts and S

2012 Program Booklet - MCD Biology - University of Colorado Boulder

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