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tweaking of the expression of that particular gene, and therefore that particular protein in a person at high risk --<br />

they are making a little too much or not quite enough," Collins added.<br />

Drugs might easily be designed to compensate, he said.<br />

The researchers did find some DNA that appears to do nothing, and it can mutate without causing any damage.<br />

Collins likened these stretches of DNA to boxes in the attic.<br />

"It is not the sort of clutter that you get rid of without consequences because you might need it. Evolution may<br />

need it," he said.<br />

That little extra padding might be just what an animal needs to adapt to some unforeseen circumstance, the<br />

researchers said. "They may become useful in the future," Birney said.<br />

© Reuters 2006. All rights reserved. Republication or redistribution of Reuters content, including by caching, framing or similar means, is expressly<br />

prohibited without the prior written consent of Reuters. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the<br />

Reuters group of companies around the world.<br />

Reuters journalists are subject to the Reuters Editorial Handbook which requires fair presentation and disclosure of relevant interests.<br />

http://uk.reuters.com/articlePrint?articleId=UKN1338205520070613<br />

Page 2 of 2<br />

6/13/2007

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