The structure and function of serpins

R E P E * R C "
Nevenheleu. the way h which roentific dimuenes amally
lead 10 marXetable pmducti - 'innovation' - or impmvemenli
m heakhcare II not well undeotood. The IradiiiOnal modcl of
innovation has been of P lin~ai pmcerç pure rereanh (reatcr
a ioune 01 new knowledge. appited reieanh exploiir thii new
afomiaton 10 tackle 1 rp~ific problem. and a devebpment
Sage grnerater the pmdvn iticif. Yet II many poliiy
rescanhen and anaiyrti have 'ontluded. thii type of model I$
to0 ~impiair ln ihe Uaii for Policy Rerearch in Science and
Mediane (PRISM) at the Wellcome Tm11, models are being
develaped 10 pmuide P bener deitnption of innovalion. For if
steps are 10 be faken 10 intenene m the exploifati~n of ICImie.
it II ellenila1 that the pricer5 !< fully undemood. IO the
ektr Of such llew-enltoni can acruraieir be predicted
PRISM'S APPROACH
A key challenge II the developmen1 oftaair 10 moniforthe flow
of knowledge withm the innovdim p mes The fis1 outpyt
from funding basic Wence II new howledge. al evidenced by
the publiraiion d mearch papes. Secondary efieitr can
include new patents. and m Ihc mediial dmm these may be
followed by new diagnostic and iherapeutvc pmduttr leading
10 impmuemcnrr n healihcire. PRISM 81 developvig techniques
10 quwbfy thew effçctr r and rnnprehenine way
To measure the eflenr of fundtng nntegier an the publication
of pope". PRKM has developed the Reearth OUfplr Database
(ROD). ROD was established 10 enable funding bodies. and
a b mearrh m$ttilyliom thcmrelver. to msww a vanety Of
queaionr. includag.
*
.
What cemnbinion does our oqmzauon make to the
pmduflian of knowledge in panicularrerearch fields m the
UK and woddrnde?
Which types of funding have been panrulady ruirerrfui in
terms of knowledge pmduflon?
'Nha1 II the geographical dirtnblsn of outputs fmm
rneanh rondvned by ourgmntholdm and what impan
don !his have on idunna1 aiiiuity?
ROD includes full bibliographi( details of a11 allitleS. noter and
WNS by UK biamedral siienii~ts. together with delads of
the Io~nel of funding knowl led god in each paper. If coven
aboyt 25 WO papes per year fmm 1988 onwardr Smpie
lemhes