Double Trouble:

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Route Site i.c./i.n. CNS i.p. periphery Immune Profile CNS: CD4, CD4, CD8 Periphery: CNS: none Periphery: CD8 > CD4 CD8 * Peak immune response for both viral infections: 6-10 dpi none Outcome 100% Survival 100% Survival Patterson et al, 2001 Khanolkar, Fuller, & Zajac, 2002
Immune response tissue-restricted ? Immune response ŅhomogenizedÓ
Page 1 and 2: Double Trouble: Consequences of Imm
Page 3 and 4: Can peripheral viral infections-or
Page 5 and 6: Outline Question Model Outcome Sign
Page 7 and 8: LCMV-Armstrong 1000-100,000 PFU LCM
Page 9: Immune-Mediated Protection of MV-in
Page 13 and 14: Fraction Original Body Weight Patho
Page 15: 10-fold increase in CD8+ T-cell inf
Page 18 and 19: Poliovirus, IC (using PVR transgeni
Page 20 and 21: I. Direct link to human disease: mi
Page 22 and 23: I. Direct link to human disease: mi
Page 24 and 25: Outline Question Model Outcome Sign
Page 26 and 27: II. Patient to patient variability

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