Double Trouble:

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Outline Question Model Outcome Significance Opportunity
I. In theory, ANY immune stimulus could contribute to immune cell mis-recruitment Viruses Bacteria Parasites Allergens Autoimmune diseases Vaccinations Graft rejection Tumor Is there a protective/amelioritive role for anti-inflammatory drugs in CNS diseases? Development of complex animal models to understand complex human diseases
Page 1 and 2: Double Trouble: Consequences of Imm
Page 3 and 4: Can peripheral viral infections-or
Page 5 and 6: Outline Question Model Outcome Sign
Page 7 and 8: LCMV-Armstrong 1000-100,000 PFU LCM
Page 9 and 10: Immune-Mediated Protection of MV-in
Page 11 and 12: Immune response tissue-restricted ?
Page 13 and 14: Fraction Original Body Weight Patho
Page 15: 10-fold increase in CD8+ T-cell inf
Page 18 and 19: Poliovirus, IC (using PVR transgeni
Page 20 and 21: I. Direct link to human disease: mi
Page 22 and 23: I. Direct link to human disease: mi
Page 26 and 27: II. Patient to patient variability

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