Double Trouble:

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I. Direct link to human disease: midbrain herniation --Occurs in humans following meningitis/encephalitis, brain tumor, trauma (that is: increased intracranial pressure)--very precipitous death, often of unknown cause --As a result of edema, midbrain pushed through foramen into spinal cord --Because the origin of the optic nerves connects to the basal midbrain, sudden, unilateral pupillary dilation is the key clinical indicator of this condition --A sense of the frequency: Cerebral malaria: 300-500 million cases annually worldwide >1 million deaths 50-75% of these (mostly children) show signs of midbrain herniation
II. Broadening how we think about human CNS disease CNS DISEASE Potential role for peripherally triggered immune responses in CNS diseases with inflammatory component: Brain tumors, MS, ALS, Parkinson’s, Alzheimer’s, stroke
Page 1 and 2: Double Trouble: Consequences of Imm
Page 3 and 4: Can peripheral viral infections-or
Page 5 and 6: Outline Question Model Outcome Sign
Page 7 and 8: LCMV-Armstrong 1000-100,000 PFU LCM
Page 9 and 10: Immune-Mediated Protection of MV-in
Page 11 and 12: Immune response tissue-restricted ?
Page 13 and 14: Fraction Original Body Weight Patho
Page 15: 10-fold increase in CD8+ T-cell inf
Page 18 and 19: Poliovirus, IC (using PVR transgeni
Page 20 and 21: I. Direct link to human disease: mi
Page 24 and 25: Outline Question Model Outcome Sign
Page 26 and 27: II. Patient to patient variability

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