Methods for Protein Structure Prediction - Fox Chase Cancer Center

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MolIDE 1.5 An open-source project <strong>for</strong> comparative modeling Implements simple modeling protocol: PSI-BLAST, Psipred, Loopy, SCWRL. Template choice, real-time alignment editing. http://dunbrack.fccc.edu/molide/molide.php Canutescu and Dunbrack, Bioin<strong>for</strong>matics, 2005 Qiang, Canutescu and Dunbrack, Nature Protocols, 2008 1050 licenses in 60 countries
Future technologies • Modeling of biologically relevant states of proteins using all available templates – homooligomers – heterooligomers – amino acid modifications – bound ligands (small molecules, nucleic acids) • Modeling of specific classes of proteins – antibodies – repeat proteins (ARM/HEAT, WD repeats)
Page 1 and 2: Methods for Protein Structure Predi
Page 3 and 4: Targets involved in DNA repair, apo
Page 5 and 6: CBS Domains of Cystathionine Beta S
Page 7 and 8: Q556H W557S W557G W557R V559A V559C
Page 9 and 10: Designing new mutations to affect f
Page 11 and 12: Hints at function Human SULT4A1 Sul
Page 13 and 14: Identification and Alignment Search
Page 15 and 16: Loop modeling Shift in loop Deletio
Page 17 and 18: Always requires: Prediction at Each
Page 19 and 20: Backbone-dependent rotamer library
Page 21: 2900 licenses in 73 countries SCWRL
Page 25 and 26: Fox Chase Cancer Center Molecular M

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