Peritonitis Management in Children on PD Peritonitis Management ...

Guidel<strong>in</strong>e 10
Empiric Antibiotic Therapy
10.1 We suggest that the center-specific antibiotic susceptibility
pattern should help guide the selection of empiric antibiotic
therapy (2B).
10.2 We suggest <strong>in</strong>traperitoneal cefepime monotherapy for the
empiric treatment of peritonitis <strong>in</strong> centers <strong>in</strong> which this antibiotic
is available and affordable (2C).
10.3 We recommend <strong>in</strong>traperitoneal adm<strong>in</strong>istration of a first
generation cephalospor<strong>in</strong>, comb<strong>in</strong>ed with ceftazidime or an
am<strong>in</strong>oglycoside if cefepime is not available (1C).
10.4 We suggest the addition of an <strong>in</strong>traperitoneal glycopeptide to
cefepime, or the replacement of a first generation cephalospor<strong>in</strong>
with an <strong>in</strong>traperitoneal glycopeptide, if the center-specific
resistance rate of S. aureus isolates to methicill<strong>in</strong> or oxacill<strong>in</strong>
exceeds 10% or if the patient has a history of MRSA (2B).